Chrysoeriol is an active ingredient derived from the Chinese medicinal herb (CMH) “Lonicerae japonicae flos” in the dried flower bud or bloomed flower of Lonicera japonica Thunberg. Dermatoses are the most common diseases in humans, including eczema, acne, psoriasis, moles, and fungal infections, which are temporary or permanent and may be painless or painful. Topical corticosteroids are widely used in Western medicine, but there are some side effects when it is continuously and regularly utilized in a large dosage. Chrysoeriol is a natural active ingredient, nontoxic, and without any adverse reactions in the treatment of dermatological conditions. Methods: Nine electronic databases were searched, including WanFang Data, PubMed, Science Direct, Scopus, Web of Science, Springer Link, SciFinder, and China National Knowledge Infrastructure (CNKI), without regard to language constraints. The pharmacological activities of chrysoeriol from Lonicerae japonicae flos to fight against skin diseases were explained and evaluated through the literature review of either in vitro or in vivo studies. Results: Chrysoeriol decreased the mRNA levels of proinflammatory cytokines IL-6, IL-1β, and TNF-α. These were transcriptionally regulated by NF-κB and STAT3 to combat skin inflammation. It also showed promising actions in treating many skin ailments including wound healing, depigmentation, photoprotection, and antiaging. Conclusion: The cutaneous route is the best delivery approach to chrysoeriol across the skin barrier. However, toxicity, dosage, and safety assessments of chrysoeriol in a formulation or nanochrysoeriol on the human epidermis for application in skin diseases must be further investigated.

Chinese medicinal herbs (CMHs) have been used for thousands of years because of their significant properties regarding the prevention and treatment of diseases, such as COVID-19. There is an increasingly diminishing supply of wild medicinal resources, and the demand is greater than the supply. Ecological balance and the conservation of natural Chinese medicinal herbs are serious issues in sustainable development, which requires the minimum requirements to be met without compromising the resources of future generations, especially with respect to the maintenance of production and consumption as well as the quality control of CMHs. Hong Kong is an urban business city, busy with work and the fast pace of life. The sustainable development of CMHs is difficult in a huge population situated in an area with very scarce land coverage. The conservation of CMHs in urban horticulture is extremely neglected because people lack living space; for example, Aquilaria Sinensis (the incense tree), also called “pak muk heung” in Cantonese, was an indigenous species that was illegally logged in the past. This led to detrimental effects on the population density and genetic diversity of the species. There is no doubt that Hong Kong is required to set up a management model in community facilities for these emerging modern social configurations, such as building a Chinese herbal garden for the conservation and promotion of a healthy urban environment and giving people a chance to gain more information on CMHs. The current study employed problem analysis and strategic decisions for the sustainable development of 62 kinds of CMHs in a Chinese herbal garden, which converged with some medicinal itineraries of Lingnan herbal medications, and implemented a theoretical framework of management models for ten secondary schools, e.g., the Aroma garden of the L’Occitane at the Technological and Higher Education Institute of Hong Kong (THEi) Tsing Yi campus and Land from the Far East Consortium International Limited in Sai Kung Pak Kong. In the present original article, we would like to establish a sustainable management model for Chinese herbal gardens in an urban city. The sustainable development model for the Chinese herbal gardens is based on five major aspects: (1) land resources, (2) manpower planning, (3) economy, (4) education or training, and (5) ecosystem (cultivation). These are the essential factors of management and are implemented in our Chinese herbal gardens. We aim to find a suitable management model for Chinese herbal gardens and to promote it in other urban cities.

The global rise of multidrug-resistant Extended Spectrum β-Lactamase Producing-Enterobacterales (ESBL-PE) poses a critical threat to public health, driving the urgent need for alternative therapeutic approaches. This study evaluates the antimicrobial properties of 20 Chinese medicinal herbs against 14 ESBL-PE strains from seven bacterial species, utilizing three extraction methods: traditional water decoction, 80% ethanol maceration, and 50% ethanol with ultrasound-assisted extraction (UAE). Among the herbs tested, Coptis chinensis Franch. demonstrated the most potent anti-ESBL-PE activity, effectively inhibiting multiple strains, including Escherichia coli, Klebsiella pneumoniae, Hafnia alvei, Citrobacter freundii and Proteus hauseri. C. chinensis extracts obtained via UAE exhibited superior antibacterial activity to the other two extraction methods, attributed to enhanced extraction efficiency and improved bioactive compound yields. Specifically, UAE increased the extraction yield of alkaloids in C. chinensis by 80.9%, compared to the ethanol maceration method, and the increase in berberine, the key antimicrobial compound, was 75.4%. Berberine demonstrated significant antibacterial effects against ESBL-PE strains, while other phytochemicals in C. chinensis extracts have an additional effect with berberine, further amplifying the overall antimicrobial activity. These findings highlight that the UAE is a promising method for enhancing the therapeutic potential of C. chinensis and other Chinese medicinal herbs against multidrug-resistant bacteria.