Phospholamban (PLN) p.Arg14del mutation carriers are known to develop dilated and/or arrhythmogenic cardiomyopathy, and typical electrocardiographic (ECG) features have been identified for diagnosis. Machine learning is a powerful tool used in ECG analysis and has shown to outperform cardiologists. We aimed to develop machine learning and deep learning models to diagnose PLN p.Arg14del cardiomyopathy using ECGs and evaluate their accuracy compared to an expert cardiologist. We included 155 adult PLN mutation carriers and 155 age- and sex-matched control subjects. Twenty-one PLN mutation carriers (13.4%) were classified as symptomatic (symptoms of heart failure or malignant ventricular arrhythmias). The data set was split into training and testing sets using 4-fold cross-validation. Multiple models were developed to discriminate between PLN mutation carriers and control subjects. For comparison, expert cardiologists classified the same data set. The best performing models were validated using an external PLN p.Arg14del mutation carrier data set from Murcia, Spain (n = 50). We applied occlusion maps to visualize the most contributing ECG regions. In terms of specificity, expert cardiologists (0.99) outperformed all models (range 0.53-0.81). In terms of accuracy and sensitivity, experts (0.28 and 0.64) were outperformed by all models (sensitivity range 0.65-0.81). T-wave morphology was most important for classification of PLN p.Arg14del carriers. External validation showed comparable results, with the best model outperforming experts. This study shows that machine learning can outperform experienced cardiologists in the diagnosis of PLN p.Arg14del cardiomyopathy and suggests that the shape of the T wave is of added importance to this diagnosis.

Great effort has been devoted in recent years to the development of sudden cardiac risk predictors as a function of electric cardiac signals, mainly obtained from the electrocardiogram (ECG) analysis. But these prediction techniques are still seldom used in clinical practice, partly due to its limited diagnostic accuracy and to the lack of consensus about the appropriate computational signal processing implementation. This paper addresses a three-fold approach, based on ECG indexes, to structure this review on sudden cardiac risk stratification. First, throughout the computational techniques that had been widely proposed for obtaining these indexes in technical literature. Second, over the scientific evidence, that although is supported by observational clinical studies, they are not always representative enough. And third, via the limited technology transfer of academy-accepted algorithms, requiring further meditation for future systems. We focus on three families of ECG derived indexes which are tackled from the aforementioned viewpoints, namely, heart rate turbulence, heart rate variability, and T-wave alternans. In terms of computational algorithms, we still need clearer scientific evidence, standardizing, and benchmarking, siting on advanced algorithms applied over large and representative datasets. New scenarios like electronic health recordings, big data, long-term monitoring, and cloud databases, will eventually open new frameworks to foresee suitable new paradigms in the near future.

Artificial intelligence (AI) has recently intensified in the global economy due to the great competence that it has demonstrated for analysis and modeling in many disciplines. This situation is accelerating the shift towards a more automated society, where these new techniques can be consolidated as a valid tool to face the difficult challenge of credit fraud detection (CFD). However, tight regulations do not make it easy for financial entities to comply with them while using modern techniques. From a methodological perspective, autoencoders have demonstrated their effectiveness in discovering nonlinear features across several problem domains. However, autoencoders are opaque and often seen as black boxes. In this work, we propose an interpretable and agnostic methodology for CFD. This type of approach allows a double advantage: on the one hand, it can be applied together with any machine learning (ML) technique, and on the other hand, it offers the necessary traceability between inputs and outputs, hence escaping from the black-box model. We first applied the state-of-the-art feature selection technique defined in the companion paper. Second, we proposed a novel technique, based on autoencoders, capable of evaluating the relationship among input and output of a sophisticated ML model for each and every one of the samples that are submitted to the analysis, through a single transaction-level explanation (STE) approach. This technique allows each instance to be analyzed individually by applying small fluctuations of the input space and evaluating how it is triggered in the output, thereby shedding light on the underlying dynamics of the model. Based on this, an individualized transaction ranking (ITR) can be formulated, leveraging on the contributions of each feature through STE. These rankings represent a close estimate of the most important features playing a role in the decision process. The results obtained in this work were consistent with previous published papers, and showed that certain features, such as living beyond means, lack or absence of transaction trail, and car loans, have strong influence on the model outcome. Additionally, this proposal using the latent space outperformed, in terms of accuracy, our previous results, which already improved prior published papers, by 5.5% and 1.5% for the datasets under study, from a baseline of 76% and 93%. The contribution of this paper is twofold, as far as a new outperforming CFD classification model is presented, and at the same time, we developed a novel methodology, applicable across classification techniques, that allows to breach black-box models, erasingthe dependencies and, eventually, undesirable biases. We conclude that it is possible to develop an effective, individualized, unbiased, and traceable ML technique, not only to comply with regulations, but also to be able to cope with transaction-level inquiries from clients and authorities.

The use of sentiment analysis methods has increased in recent years across a wide range of disciplines. Despite the potential impact of the development of opinions during political elections, few studies have focused on the analysis of sentiment dynamics and their characterization from statistical and mathematical perspectives. In this paper, we apply a set of basic methods to analyze the statistical and temporal dynamics of sentiment analysis on political campaigns and assess their scope and limitations. To this end, we gathered thousands of Twitter messages mentioning political parties and their leaders posted several weeks before and after the 2019 Spanish presidential election. We then followed a twofold analysis strategy: (1) statistical characterization using indices derived from well-known temporal and information metrics and methods –including entropy, mutual information, and the Compounded Aggregated Positivity Index– allowing the estimation of changes in the density function of sentiment data; and (2) feature extraction from nonlinear intrinsic patterns in terms of manifold learning using autoencoders and stochastic embeddings. The results show that both the indices and the manifold features provide an informative characterization of the sentiment dynamics throughout the election period. We found measurable variations in sentiment behavior and polarity across the political parties and their leaders and observed different dynamics depending on the parties’ positions on the political spectrum, their presence at the regional or national levels, and their nationalist or globalist aspirations.

Noise and artifacts are inherent contaminating components and are particularly present in Holter electrocardiogram (ECG) monitoring. The presence of noise is even more significant in long-term monitoring (LTM) recordings, as these are collected for several days in patients following their daily activities; hence, strong artifact components can temporarily impair the clinical measurements from the LTM recordings. Traditionally, the noise presence has been dealt with as a problem of non-desirable component removal by means of several quantitative signal metrics such as the signal-to-noise ratio (SNR), but current systems do not provide any information about the true impact of noise on the ECG clinical evaluation. As a first step towards an alternative to classical approaches, this work assesses the ECG quality under the assumption that an ECG has good quality when it is clinically interpretable. Therefore, our hypotheses are that it is possible (a) to create a clinical severity score for the effect of the noise on the ECG, (b) to characterize its consistency in terms of its temporal and statistical distribution, and (c) to use it for signal quality evaluation in LTM scenarios. For this purpose, a database of external event recorder (EER) signals is assembled and labeled from a clinical point of view for its use as the gold standard of noise severity categorization. These devices are assumed to capture those signal segments more prone to be corrupted with noise during long-term periods. Then, the ECG noise is characterized through the comparison of these clinical severity criteria with conventional quantitative metrics taken from traditional noise-removal approaches, and noise maps are proposed as a novel representation tool to achieve this comparison. Our results showed that neither of the benchmarked quantitative noise measurement criteria represent an accurate enough estimation of the clinical severity of the noise. A case study of long-term ECG is reported, showing the statistical and temporal correspondences and properties with respect to EER signals used to create the gold standard for clinical noise. The proposed noise maps, together with the statistical consistency of the characterization of the noise clinical severity, paves the way towards forthcoming systems providing us with noise maps of the noise clinical severity, allowing the user to process different ECG segments with different techniques and in terms of different measured clinical parameters.