Current literature and guidelines on sustainable design often debate on the advantages of natural ventilation (NV) and mechanical ventilation (MV) on indoor environment and energy consumption. The present systematic review explores the existing literature comparing NV and MV on the indoor comfort and well-being points of view. The findings emphasize that thermo-hygrometric comfort is the main driver of occupants’ ventilation behavior, while ventilation design is mainly led by indoor air quality targets. Moreover, more recent papers (especially after COVID-19 outbreak) emphasize the necessity of a health-based approach, contrasting airborne pathogens transmission. In this sense, MV is more frequently recommended in public spaces, while hybrid ventilation (HV) is often suggested as a solution to both ensure proper indoor conditions and energy savings. The concept of well-being is currently under-explored, as the present literature only refers to comfort. The same happens with topics such as visual, acoustic, and multi-domain comfort, as well as passive techniques such as night cooling, or analysis of specific environments such as healthcare facilities. Current knowledge would benefit from an expansion of future research in these directions. The choice of the best ventilation solution cannot ignore the context, type, and condition of energy efficient buildings, in order to properly take into account occupants’ well-being.

People on the autism spectrum have a different perception of the environment than neurotypical people and often require support in various activities of daily living. Assistive technology can support those affected, but very few smart-home-like technologies exist. To support people on the autism spectrum in their autonomy and safety and to help caregivers, a smart home and interior design environment was developed. Requirements were gathered by employing a holistic human-centered design approach through interactive workshops and questionnaires to create a useful and user-friendly solution. From this process, requirements for a comprehensive solution (the SENSHOME environment) emerged. These requirements include a set of functionalities tailored to the needs of people on the autism spectrum, such as a crowd warning that informs when many people are in a certain area (for example, the entrance), an automatic light regulation system, or a daily life planner that supports task completion. Furthermore, inclusive furniture elements such as a refuge seat or a table with dividers can support wellbeing, autonomy, and safety. This paper demonstrates a consequent and considerable participatory research approach and the story from the target group and context of use through design requirements to the initial design solution of the SENSHOME environment.