Interculturality is increasingly gaining conceptual and operational relevance, especially in public health, since the cultural diversity of population groups generates myriad needs and demands for health services.In this scenario, technology-mediated Massive Open Online Courses (MOOCs) have become innovative strategies for health training from an intercultural perspective (1,2). In Brazil, this is exemplified by the reinforcement of comprehensive Indigenous health care initiatives under primary health care. Prison health is also part of this spectrum of measures, as seen in the National Policy for Comprehensive Healthcare for People Deprived of Liberty. Hence, the prison population is a significant example of cultural and social diversity (3,4,5,6,7).Consideration of interculturality in the articulation of these initiatives has proven essential for health protection, promotion, and recovery across each community. It favors approaches attuned to traditional knowledge systems and practices specific to culturally diverse groups. Utilizing MOOCs in health, aligned with intercultural principles, enables professionals to be better equipped to work in culturally diverse contexts (8). MOOCs with an intercultural focus have emerged as strategic tools to broaden access to health training and facilitate intercultural practices in health professionals' practice (9,10).Interculturality is defined as a "process of interaction and exchange between different cultures aimed at mutual understanding, valuing diversity, and building peaceful and harmonious coexistence" (11). For Wang et al. (2022) (12), embracing interculturality in health care requires an understanding of the cultural norms, beliefs, and values adopted by groups in their ancestral health practices. This is essential for delivering universal and equitable health services and practices that respect people's cultural realities, traditions, and cosmovisions. Cunha et al. (2024) (11) found that by incorporating intercultural principles, health-related MOOCs help train professionals who are more culturally aware and sensitive to sociocultural diversity.In this context, the continuing education of health professionals serves as a means to understand the nexus between interculturality and health. Canty (2023) (13) highlights interculturality as a central concept to be addressed in MOOCs, which are widely used in the training of health professionals. The author emphasizes that MOOCs go beyond delivering technical knowledge to health professionals; by incorporating interculturality, they facilitate cultural exchange and foster more humanized, comprehensive, and inclusive health care practices.Health training, although traditionally centered on the technical and scientific updating of professionals, has been redefined in the Brazilian context as a key component of continuing health education (CHE). This shift recognizes that professional development must be intrinsically linked to social needs and to the demands faced by the Brazilian National Health System (SUS) (14,15). Technology-mediated CHE, particularly through Virtual Learning Environments (VLEs) and the adoption of MOOCs, has been consolidated as a fundamental strategy for the ongoing qualification of health professionals operating nationwide within the SUS (16). This approach promotes and strengthens the connection between health professionals and the population at both individual and collective levels, facilitating communication and supporting the development and adherence to health-promoting programs and practices (12,7,17). Therefore, CHE mediated by technology-such as the delivery of MOOCs and Open Educational Resources (OERs) in virtual learning environments-enhances the quality of healthcare services by overcoming geographical, cultural, and linguistic barriers to health promotion (18,19,20).One of the main global platforms for providing health-related MOOCs and OERs is the Virtual Learning Environment of the Brazilian Health System (AVASUS). AVASUS is notable for promoting large-scale education with an emphasis on emerging topics relevant to public health (21,4). Such a platform from Brazil's Ministry of Health was developed by the Laboratory for Technological Innovation in Health (LAIS) at the Federal University of Rio Grande do Norte (UFRN) through technical and scientific cooperation (7).AVASUS is currently the third-largest MOOC platform in the world, with over 3.3 million enrollments, 1.3 million users, and more than 450 open and free courses (16), totalling over 10,000 hours of content. Given its scientific, social, and national significance, AVASUS has been the subject of research, analysis, and evaluation concerning the impact of the massive MOOC and OER delivery within Brazil's SUS.In light of the above, this study aimed to structure and provide a database to enable an in-depth analysis of the relationship between interculturality and health education within primary health care. The compiled data includes demographic and geographical information on participants in 16 MOOCs offered via AVASUS, comprising 99,080 enrollees from various regions of Brazil and abroad. By compiling this information, this study aims to provide empirical support for research investigating how cultural and territorial factors influence access to, participation in, and ownership of health education content. Thus, it contributes to understanding the multiple sociocultural contexts inherent to professional training, as well as to identifying pedagogical strategies that are more sensitive to diversity and effective in promoting inclusive, comprehensive, and humanized health practices.The proposal for this study was developed using data extracted from AVASUS, covering 16 courses in the field of primary health care. Data on 99,080 enrollments and attributes spanning from December 3, 2021, to February 27, 2025, were analyzed. Emphasis was placed on elements of interculturality identified, namely:Primary...