Prof. Dr. Sixue Chen
1. Department of Biology, Genetics Institute, University of Florida, Gainesville, FL 32610, USA
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Academic Career Length
21Years (2006-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications14 September 2022 in Nature
Journal Article
RYRuiqiang Ye
Ruiqiang YeMWMeiyue Wang
Meiyue WangHDHao Du
Hao Du
SCShweta Chhajed
Shweta Chhajed
JKJin Koh
Jin Koh
JSJen Sheen
Jen Sheen +7
Journal Article
SCShweta Chhajed
Shweta ChhajedIMIslam Mostafa
Islam MostafaYHYan He
Yan HeMAMaged Abou-Hashem
Maged Abou-HashemMEMaher M. Aly El-Domiaty
Maher M. Aly El-DomiatySixue ChenInsect pests represent a major global challenge to important agricultural crops. Insecticides are often applied to combat such pests, but their use has caused additional challenges such as environmental contamination and human health issues. Over millions of years, plants have evolved natural defense mechanisms to overcome insect pests and pathogens. One such mechanism is the production of natural repellents or specialized metabolites like glucosinolates. There are three types of glucosinolates produced in the order Brassicales: aliphatic, indole, and benzenic glucosinolates. Upon insect herbivory, a “mustard oil bomb” consisting of glucosinolates and their hydrolyzing enzymes (myrosinases) is triggered to release toxic degradation products that act as insect deterrents. This review aims to provide a comprehensive summary of glucosinolate biosynthesis, the “mustard oil bomb”, and how these metabolites function in plant defense against pathogens and insects. Understanding these defense mechanisms will not only allow us to harness the benefits of this group of natural metabolites for enhancing pest control in Brassicales crops but also to transfer the “mustard oil bomb” to non-glucosinolate producing crops to boost their defense and thereby reduce the use of chemical pesticides.
Journal Article
Jinwei SuoQZQi Zhao
Qi ZhaoLDLisa David
Lisa DavidSixue ChenSDShaojun Dai
Shaojun DaiSalinity is a severe abiotic stress limiting agricultural yield and productivity. Plants have evolved various strategies to cope with salt stress. Chloroplasts are important photosynthesis organelles, which are sensitive to salinity. An understanding of molecular mechanisms in chloroplast tolerance to salinity is of great importance for genetic modification and plant breeding. Previous studies have characterized more than 53 salt-responsive genes encoding important chloroplast-localized proteins, which imply multiple vital pathways in chloroplasts in response to salt stress, such as thylakoid membrane organization, the modulation of photosystem II (PS II) activity, carbon dioxide (CO2) assimilation, photorespiration, reactive oxygen species (ROS) scavenging, osmotic and ion homeostasis, abscisic acid (ABA) biosynthesis and signaling, and gene expression regulation, as well as protein synthesis and turnover. This review presents an overview of salt response in chloroplasts revealed by gene characterization efforts.
28 November 2014 in Proteomics
Journal Article
1 October 2014 in Trends in Plant Science
Journal Article
About Me
Professor Sixue Chen completed his PhD in plant biochemistry in China and conducted postdoctoral research in Germany, Denmark, and at the University of Pennsylvania, USA. He has been a Professor in the Department of Biology and Director of Proteomics and Mass Spectrometry Facility at the University of Florida. Dr. Chen is now Professor and Chair of the Department of Biology at the University of Mississippi.
Dr. Chen has established three major research projects: plant guard cell disease triangle, glucosinolate metabolism, and photosynthesis transition from C3 to CAM. His lab is known for the application of single-cell type proteomics and mass spectrometry technologies in elucidating plant molecular networks. He has been continuously funded by the NSF, USDA, NIH, and internal university funds. In addition to his own research programs, Dr. Chen has collaborated extensively with faculty at different institutions in the USA and worldwide. His research has led to more than 300 publications.
Professor Chen serves as an Associate Editor and/or Board Member of the Archives of Proteomics and Bioinformatics, BBA-Proteins and Proteomics, Frontiers in Plant Proteomics, International Journal of Molecular Sciences, Journal of Proteomics, Metabolomics, Proteomes, and other journals. He is an elected Fellow of the American Association for the Advancement of Science.