Atmospheric pollution associated with carbon monoxide (CO), nitrogen dioxide (NO 2 ), and sulfur dioxide (SO 2 ) represents an important environmental and public health concern in Andean regions influenced by urban growth, transportation, agricultural burning, mining-related activities, and complex topography. This study analyzed the spatiotemporal variability of CO, NO 2 , and SO 2 in the Apurimac region, Peru, during 2020–2023 using Sentinel-5P/TROPOMI satellite products processed in Google Earth Engine. The original column-density data, expressed in mol/m 2 , were converted into column-derived estimated concentrations using a simplified effective lower-atmospheric layer height of 2,000 m. These values were used only as relative indicators and were not interpreted as direct ground-level air quality measurements. The results showed heterogeneous spatial patterns across Apurimac. CO presented relatively higher values mainly in Abancay, Chincheros, and Andahuaylas, while NO 2 showed higher relative values in Cotabambas, Grau, Abancay, and Chincheros. SO 2 exhibited a more irregular and uncertain behavior, with localized positive values, negative retrievals, and high variability, indicating greater sensitivity to satellite retrieval noise. Therefore, SO 2 was interpreted as an exploratory indicator rather than robust evidence of province-level pollution hotspots. Temporal analysis showed seasonal fluctuations and isolated peaks, especially during dry-season months. Trend detection was performed using the Mann-Kendall test and Sen’s slope estimator. CO showed a statistically significant decreasing trend, NO 2 showed a weak but statistically significant increasing trend, and SO 2 did not show a statistically significant trend. Overall, Sentinel-5P/TROPOMI and Google Earth Engine proved useful for identifying relative pollutant patterns in a data-sparse Andean region. Future studies should integrate satellite observations with in situ measurements, meteorological data, boundary-layer information, emission inventories, and independent datasets to improve validation, source attribution, and regional air quality assessment.