Natasha Irrera

Dr. Natasha Irrera


Research Focus & Metrics

Academic Career Length

5Years (2022-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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17 March 2022 in Molecules
Verified
Journal Article
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Alessio AlesciAlessio Alesci
Alessio Alesci
Eugenia Rita LaurianoEugenia Rita Lauriano
Eugenia Rita Lauriano
AFAngelo Fumia
Angelo Fumia
NINatasha Irrera
Natasha Irrera
EMEnza Mastrantonio
Enza Mastrantonio
Simona PergolizziSimona Pergolizzi
Simona Pergolizzi
Psoriasis is one of the most widespread chronic inflammatory skin diseases, affecting about 2%–3% of the worldwide adult population. The pathogenesis of this disease is quite complex, but an interaction between genetic and environmental factors has been recognized with an essential modulation of inflammatory and immune responses in affected patients. Psoriatic plaques generally represent the clinical psoriatic feature resulting from an abnormal proliferation and differentiation of keratinocytes, which cause dermal hyperplasia, skin infiltration of immune cells, and increased capillarity. Some scientific pieces of evidence have reported that psychological stress may play a key role in psoriasis, and the disease itself may cause stress conditions in patients, thus reproducing a vicious cycle. The present review aims at examining immune cell involvement in psoriasis and the relationship of depression and stress in its pathogenesis and development. In addition, this review contains a focus on the possible use of natural products, thus pointing out their mechanism of action in order to counteract clinical and psychological symptoms.

Verified
Journal Article
Open access
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LBLuca Di Bartolomeo
Luca Di Bartolomeo
FVFederico Vaccaro
Federico Vaccaro
NINatasha Irrera
Natasha Irrera
Francesco BorgiaFrancesco Borgia
Francesco Borgia
Federica Li PomiFederica Li Pomi
Federica Li Pomi
Mario VaccaroMario Vaccaro
Mario Vaccaro
Canonical and non-canonical Wnt signaling pathways are involved in cell differentiation and homeostasis, but also in tumorigenesis. In fact, an exaggerated activation of Wnt signaling may promote tumor growth and invasion. We summarize the most intriguing evidence about the role of Wnt signaling in cutaneous carcinogenesis, in particular in the pathogenesis of non-melanoma skin cancer (NMSC). Wnt signaling is involved in several ways in the development of skin tumors: it may modulate the inflammatory tumor microenvironment, synergize with Sonic Hedgehog pathway in the onset of basal cell carcinoma, and contribute to the progression from precancerous to malignant lesions and promote the epithelial-mesenchymal transition in squamous cell carcinoma. Targeting Wnt pathways may represent an additional efficient approach in the management of patients with NMSC.

28 January 2024 in Medicina
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Journal Article
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Federica Li PomiFederica Li Pomi
Federica Li Pomi
Mario VaccaroMario Vaccaro
Mario Vaccaro
Giovanni PallioGiovanni Pallio
Giovanni Pallio
MRMichelangelo Rottura
Michelangelo Rottura
NINatasha Irrera
Natasha Irrera
Francesco BorgiaFrancesco Borgia
Francesco Borgia
Background and Objectives: Tirbanibulin 1% ointment is a novel synthetic anti-proliferative agent that inhibits tubulin polymerization. It is approved for treating actinic keratosis (AK) on the face and scalp in adults. It has demonstrated good efficacy, an adequate safety profile and excellent patient adherence in the phase 3 clinical trials, however data about its real-life efficacy and safety are lacking. Here we report the experience of the dermatology unit of the University Hospital of Messina. Materials and Methods: We performed a spontaneous open-label, prospective non-randomized study to assess the effectiveness and safety of tirbanibulin 1% ointment for the treatment of 228 AKs in 38 consecutive patients—28 males (73%) and 10 females (26%)—aged between 52 and 92 years (mean age: 72 ± 8.92 years). Results: Total clearance was recorded in 51% of lesions, while partial clearance was recorded in 73% of lesions. An excellent tolerability profile and high compliance rate were observed, with no treatment discontinuation due to the onset of adverse events. Conclusion: Our real-life experience confirms the effectiveness and safety of tirbanibulin ointment for the treatment of AKs.

11 January 2023 in Antioxidants
Verified
Journal Article
Open access
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LBLuca Di Bartolomeo
Luca Di Bartolomeo
PCPaolo Custurone
Paolo Custurone
NINatasha Irrera
Natasha Irrera
Francesco BorgiaFrancesco Borgia
Francesco Borgia
FVFederico Vaccaro
Federico Vaccaro
Mario VaccaroMario Vaccaro
Mario Vaccaro
Vitiligo is an autoimmune dermatosis frequently associated with other comorbidities, such as mental health disorders. It is unclear if vitiligo triggers mental disorders or if mental disorders trigger vitiligo, but each one affects and worsen the other, if present at the same time. Both mental health disorders and vitiligo present a multifactorial pathogenesis and often require prolonged periods of therapy, sometimes with poor results. Given the possible link of common pathogenetic factors and the need of integrated therapies, the aim of this review is to look at natural compounds as possible supplements for both conditions. The results yielded show a possible role of these supplements in ameliorating both conditions, thus helping these patients to achieve a better quality of life and reduce the need for prolonged therapies. The limitations regarding the relative lack of in vivo studies, and the increasing need to lighten the burden of these chronic diseases, suggests that it is mandatory to proceed with further trials.

23 April 2022 in Journal of Clinical Medicine
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Journal Article
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ACAlessandro Caracciolo
Alessandro Caracciolo
Renato Francesco Maria ScaliseRenato Francesco Maria Scalise
Renato Francesco Maria Scalise
FCFabrizio Ceresa
Fabrizio Ceresa
Gianluca BagnatoGianluca Bagnato
Gianluca Bagnato
AVAntonio Giovanni Versace
Antonio Giovanni Versace
AMAntonio Micari
Antonio Micari
Percutaneous coronary intervention (PCI) is one of the most common procedures performed in medicine. However, its net benefit among patients with chronic kidney disease (CKD) is less well established than in the general population. The prevalence of patients suffering from both CAD and CKD is high, and is likely to increase in the coming years. Planning the adequate management of this group of patients is crucial to improve their outcome after PCI. This starts with proper preparation before the procedure, the use of all available means to reduce contrast during the procedure, and the implementation of modern strategies such as radial access and drug-eluting stents. At the end of the procedure, personalized antithrombotic therapy for the patient’s specific characteristics is advisable to account for the elevated ischemic and bleeding risk of these patients.

16 November 2022 in Diagnostics
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Journal Article
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LLLudovica Rosa Maria Lanzafame
Ludovica Rosa Maria Lanzafame
MCMaria Ludovica Carerj
Maria Ludovica Carerj
GRGiovanna Rizzo
Giovanna Rizzo
FMFabio Minutoli
Fabio Minutoli
GBGiuseppe Mauro Bucolo
Giuseppe Mauro Bucolo
TDTommaso D'Angelo
Tommaso D'Angelo
Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibro-inflammatory disorder. Coronary IgG4-RD has been scarcely reported and may present as “tumor-like” lesions. These pseudo-masses may be underdiagnosed mainly due to a vague clinical picture that can vary from complete lack of symptoms to acute coronary syndrome or sudden cardiac death. Early recognition of coronary IgG4-RD is essential to monitor disease activity and prevent life-threatening complications. We report a comprehensive non-invasive imaging evaluation of a patient affected by coronary IgG4-RD, which was diagnosed as an incidental finding during routine pre-laparoscopic cholecystectomy checkup. Non-invasive imaging revealed the presence of a peri-coronary soft-tissue mass that was stable at 12 months follow-up.