The amount and type of municipal solid waste (MSW) in Bahía Blanca (Argentina) were assessed and correlated with population socioeconomic level. In this sense, seven areas with different quality of life were selected. In addition, a parallel study on a control area was performed and validated for obtaining a representative result to provide analogous conclusions for the whole city. From this study, a combination of sorting methodologies is proposed in order to reduce the actual amount of waste sent to landfill. If these methodologies are implemented in Bahia Blanca city, MSW in landfill could be reduced at least 80%. The proposed strategy is to combine waste sorting at source and at destination. An alternative separation at source could be proposed as follows: packaging (including plastic, cans and Tetra Pak), other plastics, paper and glass. The rest of MSW could be included in a container which would be collected daily or three times a week without changing inhabitants’ habits and promoting their collaboration. Then, it could be separated at destination for waste-to-energy, composting, and biogas obtaining. Residuals from incinerators and biogas/composting plants would be sent to landfill. On the other hand, regarding the relationship between the proposed strategy and population quality of life, obtained results from this study could be useful to size and to efficiently locate disposal bins/containers for source separation as well as to redesign routes of municipal solid waste collection. Also, this strategy allows to add value to different components of MSW, improving working conditions of waste workers and creating new jobs in Bahia Blanca city.