Increased dietary fiber consumption has been associated with many beneficial effects, including amelioration of obesity and insulin resistance. These effects may be due to the increased production of short chain fatty acids, including propionate, acetate and butyrate, during fermentation of the dietary fiber in the colon. Indeed, oral and dietary supplementation of butyrate alone has been shown to prevent high fat-diet induced obesity and insulin resistance. This review focuses on sources of short chain fatty acids, with emphasis on sources of butyrate, mechanisms of fiber and butyrate metabolism in the gut and its protective effects on colon cancer and the peripheral effects of butyrate supplementation in peripheral tissues in the prevention and reversal of obesity and insulin resistance.

Obesity is a major health concern in the United States and many developed countries. Among its many deleterious effects are those that can affect the sexual response. To update and evaluate the state of knowledge on the possible link between obesity and sexual dysfunction. A comprehensive search and review of biomedical, physiologic, and psychological databases were used to integrate findings on obesity, weight loss, and sexual function. We briefly explain the two variables of interest-sexual functioning and obesity-indicating possible points of linkage. Then, we attempt to (i) describe possible direct links between obesity and sexual dysfunction; (ii) understand potential mediating biological, comorbid, and psychological factors and the interactions among such factors; (iii) discern differences in the mechanism and impact of obesity across the sexes; and (iv) review evidence suggesting that weight loss improves sexual functioning in obese individuals. The link between obesity and sexual function is complex and multivariate, with at least three different pathways likely: direct effects from adipose tissue; effects from pathophysiologic comorbidities; and effects mediated by psychological factors. In addition, effects and pathways appear to be different for men and women. We conclude by identifying some existing challenges for the study of obesity and sexual function, specify areas that warrant further investigation, and reiterate the potential value of encouraging obese patients to consider weight loss as a path toward a healthier and more sexually satisfying life. Rowland DL, McNabney SM, Mann AR. Sexual Function, Obesity, and Weight Loss in Men and Women. Sex Med Rev 2017;5:323-338.

Masturbation, as a significant sexual activity within its own right, has garnered substantial interest as a research topic only within the past 10–20 years. In this in-depth analysis of masturbation in women, we examined relationships among frequencies of, reasons for, and activities during masturbation, and investigated how such parameters predict orgasmic pleasure, latency, and difficulty. Participants were 2215 women at least 18 years of age participating in a 42-item opt-in online survey that collected detailed information about women’s orgasmic response during masturbation and partnered sex. Higher frequency of masturbation was related to lower satisfaction with partner, greater importance of sex, and higher levels of general anxiety/depression. Frequency of, reasons for, and activities during masturbation predicted both orgasmic pleasure and orgasmic difficulty during masturbation. The pattern of results enabled the development of three typologies of women who differ systematically with respect to their masturbation and partnered sex behaviors.

Skeletal muscle mitochondrial dysfunction, evidenced by incomplete beta oxidation and accumulation of fatty acid intermediates in the form of long and medium chain acylcarnitines, may contribute to ectopic lipid deposition and insulin resistance during high fat diet (HFD)-induced obesity. The present review discusses the roles of anterograde and retrograde communication in nucleo-mitochondrial crosstalk that determines skeletal muscle mitochondrial adaptations, specifically alterations in mitochondrial number and function in relation to obesity and insulin resistance. Special emphasis is placed on the effects of high fat diet (HFD) feeding on expression of nuclear-encoded mitochondrial genes (NEMGs) nuclear receptor factor 1 (NRF-1) and 2 (NRF-2) and peroxisome proliferator receptor gamma coactivator 1 alpha (PGC-1α) in the onset and progression of insulin resistance during obesity and how HFD-induced alterations in NEMG expression affect skeletal muscle mitochondrial adaptations in relation to beta oxidation of fatty acids. Finally, the potential ability of acylcarnitines or fatty acid intermediates resulting from mitochondrial beta oxidation to act as retrograde signals in nucleo-mitochondrial crosstalk is reviewed and discussed.

The effect of pornography on sexual response is understudied, particularly among women. A multinational, community-based sample of 2433 women at least 18 years of age completed a 42-item, opt-in questionnaire collecting information on demographic and sexual history characteristics, use of pornography during masturbation, frequency of pornography use, and sexual response parameters. Pornography use and average frequency were compared across demographic variables. We also examined how pornography frequency predicted differences in self-reported arousal difficulty; orgasmic difficulty, latency, and pleasure; and the percent of sexual activities ending in orgasm during both masturbation and partnered sex. On average, women using pornography were younger, and reported more interest in sex. Pornography frequency differed significantly by menopausal status, sexual orientation, anxiety/depression status, number of sexual partners, and origin of data collection. During masturbation, more frequent pornography use predicted lower arousal difficulty and orgasmic difficulty, greater pleasure, and a higher percentage of masturbatory events leading to orgasm. Frequency of pornography use predicted only lower arousal difficulty and longer orgasmic latencies during partnered sex, having no effect on the other outcome variables. Pornography use frequency did not predict overall relationship satisfaction or sexual relationship satisfaction. Overall, more frequent pornography use was generally associated with more favorable sexual response outcomes during masturbation, while not affecting most partnered sex parameters. Several demographic and relationship covariates appear to more consistently and strongly predict orgasmic problems during partnered sexual activity than pornography use.

Background: Compassionate caregiving is a critical skill for workers among the helping professions, but the degree of empathy required by caregivers can place high demands on their mental and emotional resources. While many professionals employ successful coping strategies to mitigate these stressors, others experience compassion fatigue or burnout from emotional exhaustion. The objective of this research was to evaluate the relationships between caregivers’ demographic/career variables, compassion satisfaction, compassion fatigue, and psychodynamic defense mechanisms such as suppression, repressive function, regression in the service of the Ego, and rationalization. Methods: Participants were 250 caregivers with 178 (71.2%) women and 72 men (28.8%) between 18 and 80 years old (Mean age = 41.37; SD = 13.78). Standardized instruments were used to assess compassion in its different meanings (Professional Quality of Life Measure, ProQOL-5) and deployment of defense mechanisms such as suppression (Suppression Mental Questionnaire, SMQ). Correlational analyses were performed. Results: Greater compassion satisfaction was positively associated with more years of study and inversely associated with increasing age and working days per week. Burnout was positively correlated with greater age, more working hours per week, and more working days per week. Higher secondary traumatic stress was associated with increasing age, higher working hours, and more working days per week, while it was inversely associated with more years of study. Regarding the psychological defense mechanisms, more years of study was inversely associated with lower deployment of the repressive function, regression in the service of the Ego, and rationalization. Advancing age was negatively correlated with repression and regression in the service of the Ego, while it was positively correlated with rationalization. A higher number of working days per week was associated with greater utilization of all defense mechanisms, and higher working hours per week was correlated with higher SMQ total scores and greater use of the repressive function. Greater deployment of nearly all defense mechanisms was associated with greater secondary traumatic stress, while compassion satisfaction was associated with less utilization of repression, rationalization, and lower total SMQ scores. Conclusions: Excessive reliance on psychodynamic defense mechanisms can increase caregivers’ risk for burnout or secondary traumatic stress. Compassion satisfaction might serve as one coping strategy to mitigate emotional exhaustion among professionals.