Anna Gryn-Rynko

Dr. Anna Gryn-Rynko

orcid

Research Focus & Metrics

Academic Career Length

5Years (2022-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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27 April 2024 in Nutrients
Verified
Journal Article
Open access
PDF file
AKAleksandra Kordas
Aleksandra Kordas
AGAnna Gryn-Rynko
Anna Gryn-Rynko
PSPatrycja Syrkiewicz
Patrycja Syrkiewicz
KKKlaudia Kitala-Tańska
Klaudia Kitala-Tańska
Michał MajewskiMichał Majewski
Michał Majewski
Cardiovascular diseases are a broadly understood concept focusing on vascular and heart dysfunction. Lack of physical exercise, type 2 diabetes, obesity, hypertension, dyslipidemia, thromboembolism, and kidney and lung diseases all contribute to the development of heart and blood vessel dysfunction. Although effective and important, traditional treatment with diuretics, statins, beta blockers, calcium inhibitors, ACE inhibitors, and anti-platelet drugs remains a second-line treatment after dietary interventions and lifestyle changes. Scientists worldwide are still looking for an herbal product that would be effective and free from side effects, either taken together with or before the standard pharmacological intervention. Such herbal-originated medication therapy may include Morus alba L. (white mulberry), Elaeagnus rhamnoides (L.) A. Nelson (sea-buckthorn), Allium sativum L. (garlic), Convallaria majalis L. (lily of the valley), Leonurus cardiaca L. (motherwort), and Crataegus spp. (hawthorn). Valuable herbal raw materials include leaves, fruits, seeds, and even thorns. This short review focuses on six herbs that can constitute an interesting and potential therapeutic option in the management of cardiovascular disorders.

17 December 2022 in Molecules
Verified
Journal Article
Open access
PDF file
AGAnna Gryn-Rynko
Anna Gryn-Rynko
BSBeata Sperkowska
Beata Sperkowska
Michał MajewskiMichał Majewski
Michał Majewski
Tyrosinase is a multifunctional, copper-containing and rate-limiting oxidase that catalyses crucial steps in the melanogenesis pathway and is responsible for skin-pigmentation abnormalities in mammals. Numerous tyrosinase inhibitors derived from natural and synthetic sources have been identified as an objective for the development of anti-melanogenesis agents. However, due to side effects and lack of expected efficiency, only a small percentage of them are used for medical and cosmetic purposes. This critical review focuses on searching for novel active substances and recently discovered plant-derived anti-tyrosinase inhibitors from the Morus genus (Moraceae family). A detailed analysis of their structure–activity relationships is discussed. The information contained in this article is crucial for the cosmetics and medical industries, in order to show new directions for the effective search for natural anti-melanogenesis products (with satisfactory efficiency and safety) to treat and cure hyperpigmentation.

15 April 2025 in Scientific Reports
Verified
Journal Article
Open access
PDF file
MJMichał Adam Janiak
Michał Adam Janiak
AGAnna Gryn-Rynko
Anna Gryn-Rynko
KSKatarzyna Sulewska
Katarzyna Sulewska
Ryszard AmarowiczRyszard Amarowicz
Ryszard Amarowicz
KPKamila Penkacik
Kamila Penkacik
MMMichał Stanisław Majewski
Michał Stanisław Majewski
The aim of this study was to compare the phenolic compound content and antioxidant activity of infusions made from commercially available Morus alba L. leaves with those of infusions made from a naturally collected source. The phenolic profile was determined using RP-HPLC–DAD and LC-Q-TOF–MS/MS. The total phenolic content (TPC) was determined using Folin-Ciocâlteu reagent. To assess the antioxidant and reducing properties, Trolox equivalent antioxidant capacity (TEAC) and ferric reducing antioxidant power (FRAP) were used. Our analysis revealed the presence of two phenolic acids and six flavonoids. The most abundant compound was chlorogenic acid. The TPC, TEAC, and FRAP results indicated that infusions prepared from naturally collected samples exhibited greater phenolic content (19.7—52.6 vs 18.1—35.2 mg/100 ml) and stronger antioxidant (0.0605—0.1842 vs 0.0453—0.0822 mmol Trolox/100 ml) and reducing (0.244—0.597 vs 0.202—0.371 mmol Fe2+/100 ml) activities than those of commercially available products in the Polish market. Samples L1-L3 from the natural collection were those with the highest values. These results were further supported by principal component analysis (PCA), which categorized observations into three distinct clusters.

22 March 2024 in Preprints.org
Verified
Preprint
Open access
PDF file
AKAleksandra Kordas
Aleksandra Kordas
AGAnna Gryn-Rynko
Anna Gryn-Rynko
PSPatrycja Syrkiewicz
Patrycja Syrkiewicz
KKKlaudia Kitala-Tańska
Klaudia Kitala-Tańska
Michał MajewskiMichał Majewski
Michał Majewski
Cardiovascular diseases are a broadly understood concept focusing on vascular and heart dys-function. Lack of physical exercise, type 2 diabetes, obesity, hypertension, dyslipidemia, throm-boembolism, kidney, and lung diseases all contribute to the development of heart and blood vessel dysfunction. Although effective and important, traditional treatment with diuretics, statins, beta–blockers, calcium inhibitors, ACE inhibitors, and anti–platelet drugs remain a second–line treatment after dietary intervention and lifestyle changes. Scientists worldwide are still looking for an herbal product that would be quite effective and free from side effects, either taken together or before the standard pharmacological intervention. Such herbal–originated medication therapy may include Morus alba L. (white mulberry), Elaeagnus rhamnoides (L.) A. Nelson (sea–buckthorn), Allium sativum L. (garlic), Convallaria majalis L. (lily of the valley), Leonurus cardiaca L. (mother-wort), and Crataegus spp. (hawthorn). Valuable herbal raw materials include leaves, fruits, seeds, and even thorns. This short review focuses on six herbs that can constitute an interesting and po-tential therapeutic option in the management of cardiovascular disorders.

24 October 2025 in Nutrients
Verified
Journal Article
Open access
PDF file
BSBeata Sperkowska
Beata Sperkowska
ACAgnieszka Chrustek
Agnieszka Chrustek
AGAnna Gryn-Rynko
Anna Gryn-Rynko
APAnna Proszowska
Anna Proszowska
Background/Objectives: Medical nutrition therapy (MNT) is a crucial component of type 1 diabetes (T1D) management; however, the effectiveness of specific dietary approaches in adults remains unclear due to variations in study design, terminology, and reported outcomes. This scoping review summarizes evidence published between 2015 and 2025 on dietary interventions in adults with T1D, focusing on metabolic and psychosocial outcomes and adherence to international nutritional guidelines. Methods: We searched PubMed, Web of Science, Scopus, and Google Scholar, following the PRISMA-ScR recommendations, to identify observational studies, randomized clinical trials (RCTs), and guidelines involving adults (≥18 years) with T1D. Extracted data included metabolic outcomes (glycated hemoglobin A1c (HbA1c), glycemic variability (GV), insulin dose (ID), lipids, blood pressure, body weight, and others), as well as psychosocial indicators (i.e., quality of life, diabetes-related stress, and fear of hypoglycemia). Results: In total, 41 studies met the inclusion criteria, comprising 18 observational, 14 randomized, and 9 studies that evaluated psychosocial aspects. A low-carbohydrate diet (LCD) reduced HbA1c by 0.3–0.9% and total ID by approximately 15–20% without increasing the incidence of severe hypoglycemia. A low-fat vegan diet and structured carbohydrate counting (CC) programs also improved glycemic and lipid profiles. The Mediterranean diet (MedDiet) and plant-based diet mainly improved diet quality and well-being. The results showed an association between better metabolic control and lower carbohydrate (CHO) intake, as well as higher intakes of fiber and protein. In contrast, a Western diet and high intake of sweets were linked to poorer outcomes. Conclusions: Combining an LCD with education, CC, and modern diabetes technology provides the most consistent benefits for adults with type 1 diabetes (T1D adults). The MedDiet and plant-based diet support diet quality and psychosocial well-being, although current evidence remains limited, primarily due to small sample sizes and short follow-up periods.

11 June 2025 in Scientific Reports
Verified
Journal Article
Open access
PDF file
MJMichał Adam Janiak
Michał Adam Janiak
AGAnna Gryn-Rynko
Anna Gryn-Rynko
KSKatarzyna Sulewska
Katarzyna Sulewska
RARyszard Amarowicz
Ryszard Amarowicz
KPKamila Penkacik
Kamila Penkacik
MMMichał Stanisław Majewski
Michał Stanisław Majewski