Background: Follistatin-like 1 (FSTL1) is recently becoming a novel cardiokine essential in cardiac angiogenesis. This cardiokine has shown a potential to promote angiogenesis and improve cardiac function, particularly in myocardial injury and ischemia. Despite the increasing relevance, there is no information on the mechanisms of FSTL1 in cardiac angiogenesis. Objective: This systematic review aimed to consolidate recent results on the role of FSTL1 in molecular pathways of cardiac angiogenesis. Methods: A comprehensive search was conducted using various databases, including PubMed, Scopus, SpringerLink, and ScienceDirect. Inclusion criteria were primary studies that investigated the role of FSTL1 in promoting cardiac angiogenesis with in vivo models. The risk of bias was assessed using SYRCLE risk of bias tool, and data were synthesized to evaluate the impact of FSTL1 on cardiac angiogenesis. Results: A total of 5 animal studies were included during the analysis. The results showed the role of FSTL1 as a novel cardiokine in inducing cardiac angiogenesis as assessed by protein examination and histologic analysis. In pathological conditions, the effects of ischemia on the heart increased the expression of FSTL1 as a form of protection for the heart through angiogenesis and as a marker of the disease severity. Furthermore, the molecular mechanisms of FSTL-induced angiogenesis had different signaling pathways, including activation of AMPK, TGFβ-Smad2/3, Akt/mTOR, Erk1/2, and DIP2A-PI3K. Studies showed increased capillary density and improved blood flow in cardiac tissues where FSTL1 was upregulated, suggesting a possible important role in improving cardiac function. Conclusion: FSTL1 showed a promising avenue for therapeutic development. Moreover, future studies should explore its role in cardiac angiogenesis in healthy populations.

Background: Chronic diseases are an increase global health concern driven by aging populations and lifestyle changes. In Asia, rapid demographic shifts and diverse healthcare systems pose unique challenges for chronic disease management. Internet-based remote monitoring systems offer innovative solutions for early detection and timely intervention, but their effectiveness within the varied Asian context requires thorough evaluation. Purpose: This systematic review aimed to evaluate the effectiveness of internet-based remote monitoring systems in managing outcomes among patients with chronic diseases. Methods: A systematic literature search was conducted across major electronic databases, including PubMed, Scopus, Taylor and Francis, and EBSCOhost, employing a combination of relevant search terms. The keywords used were “remote monitoring OR telemonitoring OR internet-based monitoring AND chronic disease OR chronic illness AND patient outcome OR health outcome OR clinical outcome”. The inclusion criteria are defined using the PICO framework. The data were analyzed descriptively and qualitatively using thematic analysis. Results: Following rigorous screening and quality appraisal, 16 studies met the inclusion criteria. These studies employed diverse remote monitoring modalities, encompassing automated remote monitoring systems, patient-reported monitoring, and personalized telecommunication-based approaches. The evidence demonstrates that internet-based remote monitoring systems significantly enhance chronic disease management across various Asian contexts. Conclusion: Internet-based remote patient monitoring constitutes a pivotal advancement in chronic disease management. It facilitates timely emergency responses, reduces healthcare utilization, and optimizes clinical outcomes within Asian healthcare settings. Future efforts should focus on synergizing automated data acquisition, patient self-reporting, and personalized communication to overcome challenges related to sustained behavioral change and quality-of-life improvements.

Background: Infection Prevention and Control Linked Nurses (IPCLN) are the spearhead of implementing the Infection Control Prevention Program. The performance of nurses in preventing and controlling infections during the Covid-19 pandemic greatly influenced the quality of services. Objective: This study aimed to determine the factors that influence the performance of IPCLN during the Covid-19 pandemic. Methods: Cross-sectional study was performed on 34 nurses at Cicendo Eye Hospital with a total sampling technique. The questionnaire in this study included knowledge, motivation, supervision, and the performance of nurses which had previously been tested with these characteristics with a result of Cronbach's alpha of 0.75. Data were analyzed using univariate, bivariate, and multivariate analyses. Results: The mean score of IPCLN knowledge in this study was 14.82 ± 4.01, motivation 92.47 ± 15.85, supervision 34.74 ± 5.89, and performance 7.94 ± 2.71. There is a relationship between knowledge ( p = .000), motivation ( p = .000), and supervision ( p = .000) on nurse performance. Motivation is the dominant factor influencing IPCLN performance compared to knowledge and supervision (Stand. Estimate = 0.5121; 95% CI = 0.1301–0.487; p < .001). Conclusion: Motivation is a dominant factor in IPCLN performance in this study. However, hospital management needs to maximize and make policies to improve IPCLN performance in terms of motivation. These policies can be through providing incentives for nurses, developing free continuing education programs, and issuing funds for nursing education scholarships.

ABSTRAKPenurunan kebugaran jasmani berkontribusi terhadap angka kesakitan dan kematian lansia. Kebugaran jasmani seseorang yang berusia > 60 tahun ditentukan oleh tingkat kebugaran jasmani melalui Senam jantung Sehat Seri-I, namun aktivitasnya memerlukan frekuensi yang tepat agar tidak menimbulkan cedera olahraga. Tujuan dari penelitian ini adalah untuk menganalisis frekuensi Senam jantung Sehat Seri-I yang dapat meningkatkan kebugaran jasmani pada lansia. Penelitian ini menggunakan metode pre-experimental dengan pendekatan pre-test dan post-test design yang mengikutsertakan 27 lansia sehat dan rutin melakukan senam Jantung Sehat Seri-I yang tinggal di Panti Whreda. Subjek penelitian terbagi menjadi 3 kelompok berdasarkan frekuensi aktifitas senam per minggu yaitu 3,4, dan 5 kali seminggu selama 6 minggu. Peningkatan kebugaran jasmani ditentukan melalui jarak tempuh yang dilalui lansia setelah tes jalan 6 menit (six minutes test) pada minggu ke-1 dan ke-6. Perbedaan rata-rata jarak tempuh setelah dilakukan senam secara statistik dianalis menggunakan uji-t berpasanan dengan p-value 60 years is determined by the level of physical fitness through a six minutes test.. Efforts to improve physical fitness levels are needed for sports, one of which is Senam Jantung Sehat Seri-I, which takes into account the frequency of exercise. The purpose of this study was to analyze the frequency of Senam Jantung Sehat Seri-I that can improve cardiorespiratory fitness in the elderly. This study used a pre-experimental method with a pre-test and post-test design approach that included 27 healthy elderly people and routinely carried out Senam Jantung Sehat Seri-I exercises at the Nursing Home. The research subjects were divided into 3 groups based on the frequency of gymnastics activity per week which was 3.4, and 5 times a week for 6 weeks. Improved physical fitness was determined through the distance traveled on the 6-minute test at weeks 1 and 6. The difference in statistically traveled distance was analyzed using Independent t-test with a p-value <0.05 expressed as significant. The elderly group who did Senam Jantung Sehat Seri-I 3 times a week had a significant mean difference (-106.0; p = 0.009), while groups 4 and 5 times a week did not show significant results. In conclusion, this study provides evidence that Senam Jantung Sehat Seri-I 3 times a week improves cardiorespiratory fitness.

Background: The mobilization characteristics of nurses’ work, such as standing, walking, and transferring patients for a long time, can increase the risk of musculoskeletal disorders. Repetitive activities nurses perform can cause foot problems such as discomfort and insecurity, characterized by increased lactic acid levels. Anthropometric shoes are specifically designed to reduce complaints on nurses’ feet. Purpose: This study aimed to determine the effect of individual anthropometric shoes on lactic acid levels in nurses at the hospital. Methods: This study used a mixed-method study design. This study involved 71 nurses in the quantitative study and 15 nurses in the qualitative study. Nurses in Emergency Room, Central Surgical Installation, Inpatient Room, Intensive Care Unit, and Outpatient Installation were randomly selected using a stratified random sampling technique. The instruments used were the Accutrend Lactacyd tool, demographic questionnaire and interview questionnaire. Bivariate data analysis was using Statistical Package for Social Sciences (SPSS) and qualitative data analysis using thematic analysis. Results: This mixed-method study shows that anthropometric shoes can reduce nurses’ lactic acid levels. In the quantitative study; there was a significant difference in lactic acid levels of nurses before and after using anthropometric shoes with the average results of measuring lactic acid levels, namely pre-test (22.48 mg/dL) and post-test (16.27 mg/dL), with a p-value (0.000). The qualitative study data revealed positive results related to increased nurse knowledge, positive views on the effect of shoes on nurse performance, and the impact of using anthropometric shoes in providing comfort and safety, such as decreased muscle fatigue and pain. Conclusion: The findings of this study highlight the effect of individualized anthropometric shoes on lactic acid levels in nurses in Indonesian hospitals. It is essential to conduct further research and evaluate the results in a broader setting to ensure that anthropometric shoes can directly affect lactic acid levels.

This study was aimed at determining the description of predominant physical component profile (physical fitness, fat thickness, agility, muscle endurance, flexibility, power, muscle strength and balance) of the Persipura Junior Football Athletes. This study used a survey of PERSIPURA Junior Football athletes involving 39 people. The inclusions of the athletes inculde male gender, aged 21 years, height 177 cm, an ideal body weight, a healthy body, and moderate to good categories of physical fitness. The instrument used in this study were dynamometer for muscle strength; crunches for muscular endurance, push-ups, squat jumps, beam side step for agility, flexometer for flexibility, vertical jump for power, and 2.4 km running test for physical fitness. The results showed that the Persipura Junior Football athletes had a good physical fitness, less triceps fat thickness, a normal sub scapular thickness, a normal supra iliaca thickness, lack of agility, a good endurance of arm and shoulder muscles, a good endurance of abdominal muscles, an adequate flexibility, a perfect vertical jump muscle power, a good medicine ball muscle explosive power, a good full muscle strength, lack push muscle strength, and a very good balance. It concludes that to gain an optimal predominant physical component, sports science with measurable and well-programmed exercises should be applied, so that the physical component of triceps fat thickness, agility, and push muscle strength could increase. Abstrak Penelitian ini bertujuan untuk mengidentifikasi Profil Komponen Fisik Predominan (Kebugaran Jasmani, Ketebalan Lemak, Kelincahan, Daya Tahan Otot, Kelentukan, Daya Ledak Otot, Kekuatan Otot dan Keseimbangan) Atlet Pemain Sepak Bola Persipura Junior. Penelitian ini menggunakan survei terhadap atlet Sepak Bola PERSIPURA Junior sebanyak 39 orang, yang memiliki inklusi: jenis kelamin laki-laki, umur 21 tahun, tinggi badan 177 cm, berat badan ideal, berbadan sehat dan kebugaran fisik dengan kategori sedang sampai kategori baik. Instrumen untuk mengukur kekuatan otot dengan dinamometer; daya tahan otot diukur dengan sit-up, push-up, squat jumps; kelincahan diukur dengan beam side step, kelentukan diukur dengan fleksometer, daya ledak otot diukur dengan vertical jump, dan kebugaran jasmani diukur dengan tes lari 2,4 km. Hasil Penelitian menunjukkan atlet Pemain Sepak Bola Persipura Junior memiliki kebugaran jasmani baik, ketebalan lemak triceps kurang, ketebalan sub scapula normal, ketebalan supra iliaca normal, kelincahan kurang, daya tahan otot lengan dan bahu baik sekali, daya tahan otot perut baik, kelentukan cukup, daya ledak otot vertical jump sempurna, daya ledak otot medicine ball baik, kekuatan otot full baik , kekuatan otot push kurang, keseimbangan baik sekali. Agar komponen fisik predominan optimal, hendaknya menerapkan sports science dengan latihan terukur dan terprogram dengan baik sehingga komponen fisik ketebalan lemak triceps, kelincahan dan kekuatan otot push meningkat.