Citizen science offers a unique opportunity to connect urban-dwellers with the often hidden natural world upon their doorsteps and to contribute to authentic research that increases knowledge of urban ecology and biodiversity. With the majority of Australia’s population residing in large cities, this diverse potential pool of participants in science creates a significant opportunity to increase the spatial and temporal scale of research. Herein, we provide an overview of Australian urban citizen science projects based on an analysis of the projects listed in the Australian Citizen Science Association’s Citizen Science Project Finder. We draw out key features (such as those with research questions specific to cities such as reintroduction and persistence of species in urban environments) from urban citizen science projects that make them suitable for the urban environment and use these features to suggest recommendations for further expansion and development of this important subset of projects. We conclude that the number and diversity of urban citizen science projects is relatively low in Australia, and advocate for an increase in initiatives that can tap into a large pool of potential participants for the benefit of science and society.

The Open Source Malaria (OSM) consortium is developing compounds that kill the human malaria parasite, Plasmodium falciparum, by targeting PfATP4, an essential ion pump on the parasite surface. The structure of PfATP4 has not been determined. Here, we describe a public competition created to develop a predictive model for the identification of PfATP4 inhibitors, thereby reducing project costs associated with the synthesis of inactive compounds. Competition participants could see all entries as they were submitted. In the final round, featuring private sector entrants specializing in machine learning methods, the best-performing models were used to predict novel inhibitors, of which several were synthesized and evaluated against the parasite. Half possessed biological activity, with one featuring a motif that the human chemists familiar with this series would have dismissed as “ill-advised”. Since all data and participant interactions remain in the public domain, this research project “lives” and may be improved by others.