Security of sensitive data exchanged between devices is essential. Low-resource devices (LRDs), designed for constrained environments, are increasingly becoming ubiquitous. Lightweight block ciphers provide confidentiality for LRDs by balancing the required security with minimal resource overhead. SIMON is a lightweight block cipher targeted for hardware implementations. The objective of this research is to implement, optimize, and model SIMON cipher design for LRDs, with an emphasis on energy and power, which are critical metrics for LRDs. Various implementations use field-programmable gate array (FPGA) technology. Two types of design implementations are examined: scalar and pipelined. Results show that scalar implementations require 39% less resources and 45% less power consumption. The pipelined implementations demonstrate 12 times the throughput and consume 31% less energy. Moreover, the most energy-efficient and optimum design is a two-round pipelined implementation, which consumes 31% of the best scalar’s implementation energy. The scalar design that consumes the least energy is a four-round implementation. The scalar design that uses the least area and power is the one-round implementation. Balancing energy and area, the two-round pipelined implementation is optimal for a continuous stream of data. One-round and two-round scalar implementations are recommended for intermittent data applications.

Thyroid disease is among the most prevalent endocrinopathies worldwide. As the thyroid gland controls human metabolism, thyroid illness is a matter of concern for human health. To save time and reduce error rates, an automatic, reliable, and accurate thyroid identification machine-learning (ML) system is essential. The proposed model aims to address existing work limitations such as the lack of detailed feature analysis, visualization, improvement in prediction accuracy, and reliability. Here, a public thyroid illness dataset containing 29 clinical features from the University of California, Irvine ML repository was used. The clinical features helped us to build an ML model that can predict thyroid illness by analyzing early symptoms and replacing the manual analysis of these attributes. Feature analysis and visualization facilitate an understanding of the role of features in thyroid prediction tasks. In addition, the overfitting problem was eliminated by 5-fold cross-validation and data balancing using the synthetic minority oversampling technique (SMOTE). Ensemble learning ensures prediction model reliability owing to the involvement of multiple classifiers in the prediction decisions. The proposed model achieved 99.5% accuracy, 99.39% sensitivity, and 99.59% specificity with the boosting method which is applicable to real-time computer-aided diagnosis (CAD) systems to ease diagnosis and promote early treatment.