Leonardo Benelli

Dr. Leonardo Benelli

orcid

Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
1 June 2021 in Annales de Cardiologie et d'Angéiologie
Verified
Journal Article
Closed access
CDCarlo Di Donna
Carlo Di Donna
ACArmando Ugo Cavallo
Armando Ugo Cavallo
LPLuca Pugliese
Luca Pugliese
FRFrancesca Ricci
Francesca Ricci
VSVincenzo De Stasio
Vincenzo De Stasio
MCMarcello Chiocchi
Marcello Chiocchi

25 September 2020 in Journal of Medical Case Reports
Verified
Journal Article
Open access
PDF file
MCMarcello Chiocchi
Marcello Chiocchi
LSLuigi Spiritigliozzi
Luigi Spiritigliozzi
FTFederica Di Tosto
Federica Di Tosto
LBLeonardo Benelli
Leonardo Benelli
FEFrancesca D Errico
Francesca D Errico
RFRoberto Floris
Roberto Floris
Background An ascending aortic pseudoaneurysm is a severe and rare complication following cardiothoracic surgery. This case report demonstrates its possible misinterpretation and the consequent importance of multidisciplinary evaluation. Case presentation We present a case of an 18-year-old Caucasian man with Marfan syndrome who developed an ascending aortic pseudoaneurysm about 1 year after undergoing cardiac surgery with the Bentall procedure. Computed tomographic examination of the thoracic aorta and positron emission tomography-computed tomography initially suggested a lymphomatous pathology. However, these imaging results were in contrast to the transesophageal echocardiogram and the laboratory data that showed negative results for hematological pathology. A second computed tomographic scan redirected the diagnosis toward a pseudoaneurysm. Conclusion This case demonstrates the utility of close communication and interdisciplinary consultation between cardiovascular radiologists and the cardiac surgery team, which are mandatory in order to maximize their diagnostic skills in identifying postoperative complications.

26 January 2023 in Medicina
Verified
Journal Article
Open access
PDF file
MCMarcello Chiocchi
Marcello Chiocchi
ACArmando Ugo Cavallo
Armando Ugo Cavallo
LPLuca Pugliese
Luca Pugliese
MCMatteo Cesareni
Matteo Cesareni
Daniela PasqualiDaniela Pasquali
Daniela Pasquali
CDCarlo Di Donna
Carlo Di Donna
Background and objectives: Epicardial adipose tissue density (EAD) has been associated with coronary arteries calcium score, a higher load of coronary artery disease (CAD) and plaque vulnerability. This effect can be related to endocrine and paracrine effect of molecules produced by epicardial adipose tissue (EAT), that may influence myocardial contractility. Using coronary computed tomography angiography (CCT) the evaluation of EAD is possible in basal scans. The aim of the study is to investigate possible associations between EAD and cardiac function. Material and Methods: 93 consecutive patients undergoing CCT without and with contrast medium for known or suspected coronary CAD were evaluated. EAD was measured on basal scans, at the level of the coronary ostia, the lateral free wall of the left ventricle, at the level of the cardiac apex, and at the origin of the posterior interventricular artery. Cardiac function was evaluated in post-contrast CT scans in order to calculate ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), and stroke volume (SV). Results: A statistically significant positive correlation between EAD and ejection fraction (r = 0.29, p-value < 0.01) was found. Additionally, a statistically significant negative correlation between EAD and ESV (r = −0.25, p-value < 0.01) was present. Conclusion: EAD could be considered a new risk factor associated with reduced cardiac function. The evaluation of this parameter with cardiac CT in patients with low to intermediate cardiovascular risk is possible.

Verified
Journal Article
Open access
PDF file
FRFrancesca Ricci
Francesca Ricci
LBLeonardo Benelli
Leonardo Benelli
MPMonia Pasqualetto
Monia Pasqualetto
Mario LaudaziMario Laudazi
Mario Laudazi
LPLuca Pugliese
Luca Pugliese
MCMarcello Chiocchi
Marcello Chiocchi
Scope: The main purpose of our study was to collect computed tomography (CT) measurements of fat parameters that are significantly related to body mass index (BMI) and evaluate the associations of these measurements and sarcopenia with early and long-term complications after transcatheter aortic valve implantation (TAVI) in order to investigate the existence of the so-called ‘obesity paradox’ and the role of sarcopenia in this phenomenon. Materials and Methods: We analyzed the significance of fat CT measurements in 85 patients undergoing the TAVI procedure and compared these with each other, as well as with quantified CT BMI and fat density measurements. Secondly, we evaluated the associations of BMI, CT measurements of fat, and CT evaluations of skeletal muscle mass with early and long-term complications after 24 months of post-TAVI follow-up. Results: We found positive and significant relationships between fat CT measurements with each other and with BMI and a negative and significant relation between fat density and fat quantity. By comparing the CT measurements of fat and skeletal muscle mass with early and long-term complications after TAVI, we confirmed the existence of the ‘obesity paradox’ and the poor effect of sarcopenia after the TAVI procedure. Conclusions: We confirm that overweight and obesity are good prognostic factors, and sarcopenia is a poor prognostic factor for outcomes following the TAVI procedure. We focused on the scientific validation of an easy and fast way to measure fat and skeletal muscle mass using CT to better predict the outcomes of patients undergoing TAVI.