A growing body of experimental evidence suggests that microRNAs (miRNAs) are closely associated with specific human diseases and play critical roles in their development and progression. Therefore, identifying miRNA related to specific diseases is of great significance for disease screening and treatment. In the early stages, the identification of associations between miRNAs and diseases demanded laborious and time-consuming biological experiments that often carried a substantial risk of failure. With the exponential growth in the number of potential miRNA-disease association combinations, traditional biological experimental methods face difficulties in processing massive amounts of data. Hence, developing more efficient computational methods to predict possible miRNA-disease associations and prioritize them is particularly necessary. In recent years, numerous deep learning-based computational methods have been developed and have demonstrated excellent performance. However, most of these methods rely on external databases or tools to compute various auxiliary information. Unfortunately, these external databases or tools often cover only a limited portion of miRNAs and diseases, resulting in many miRNAs and diseases being unable to match with these computational methods. Therefore, there are certain limitations associated with the practical application of these methods. To overcome the above limitations, this study proposes a multi-view computational model called MVNMDA, which predicts potential miRNA-disease associations by integrating features of miRNA and diseases from local views, global views, and semantic views. Specifically, MVNMDA utilizes known association information to construct node initial features. Then, multiple networks are constructed based on known association to extract low-dimensional feature embedding of all nodes. Finally, a cascaded attention classifier is proposed to fuse features from coarse to fine, suppressing noise within the features and making precise predictions. To validate the effectiveness of the proposed method, extensive experiments were conducted on the HMDD v2.0 and HMDD v3.2 datasets. The experimental results demonstrate that MVNMDA achieves better performance compared to other computational methods. Additionally, the case study results further demonstrate the reliable predictive performance of MVNMDA.

Small non-coding molecules known as microRNAs (miRNAs) play a critical role in disease diagnosis, treatment, and prognosis evaluation. Traditional wet-lab methods for validating miRNA–disease associations are often time-consuming and inefficient. With the advancement of high-throughput sequencing technologies, deep learning methods have become effective tools for uncovering potential patterns in miRNA–disease associations and revealing novel biological insights. Most of the existing approaches focus primarily on individual molecular behavior, overlooking interactions at the multi-molecular level. Conventional graph neural network (GNN) models struggle to generalize to heterogeneous graphs, and as network depth increases, node representations become indistinguishable due to over-smoothing, resulting in reduced predictive performance. GONNMDA first integrates similarity features from multiple data sources and applies noise reduction to obtain a reconstructed, comprehensive similarity representation. It then constructs heterogeneous graphs and applies a root–tree hierarchical alignment, along with an ordered gating message-passing mechanism, effectively addressing the challenges of heterogeneity and over-smoothing. Finally, a multilayer perceptron is employed to produce the final association predictions. To evaluate the effectiveness of GONNMDA, we conducted extensive experiments where the model achieved an AUC of 95.49% and an AUPR of 95.32%. The results demonstrate that GONNMDA outperforms several recent state-of-the-art methods. In addition, case studies and survival analyses on three common human cancers—breast cancer, rectal cancer, and lung cancer—further validate the effectiveness and reliability of GONNMDA in predicting miRNA–disease associations.

Accurate change detection in multi-temporal remote sensing imagery is hindered by semantic ambiguity from heterogeneous land covers and the challenge of capturing fine-grained structural changes. Existing methods based on convolutional or self-attention mechanisms often suffer from limited receptive fields, high computational costs, redundant features, and insufficient exploitation of frequency-domain structural cues. To overcome these limitations, we propose OSAWaveNet, a novel change detection network that integrates Orthogonal Semantic Axes-guided Context Clustering (OSACC) and Frequency-Enhanced Difference Feature Learning (FEDFL) within an end-to-end encoder-decoder architecture. The OSACC introduces fixed, strictly orthogonal semantic axes in similarity space to guide pixel-wise context clustering, thereby enhancing intra-class consistency and suppressing pseudo-changes caused by seasonal or illumination variations. The FEDFL decomposes spatial difference features into complementary frequency components via discrete wavelet transform, low-frequency modeling reinforces global semantic coherence, while high-frequency enhancement sharpens boundaries. Furthermore, a Multi-Level Attention-Guided Difference Decoder (MAGDD) adaptively fuses spatial and frequency-domain cues to achieve precise change localization and robust discrimination against noise and pseudo-changes. Extensive experiments on three public datasets demonstrate that the proposed method consistently outperforms state-of-the-art approaches, with an average improvement of 1.7% in F1-score and 1.5% in overall accuracy. The code is available at https://github.com/yangchen0372/OSAWaveNet.

Remote sensing change detection (RSCD), a fundamental task in Earth observation, aims to automatically identify land-cover changes (e.g., building construction, vegetation degradation) by comparing multitemporal satellite or aerial images of the same region. With the explosive growth of high-resolution remote sensing data, achieving real-time accurate change detection on edge computing devices (e.g., drone-embedded chips, satellite on-board processors) has become an urgent challenge—existing deep learning methods, despite high accuracy, are hindered by massive parameters and computational costs that preclude deployment on resource-constrained embedded hardware. To address this, we focus on lightweight (i.e., low parameter count and low computational cost) RSCD network design, targeting three critical bottlenecks: blurred boundaries of changed regions, missed detection of small objects, and insufficient computational efficiency. We propose ATCFNet (Adjacent-Temporal Cross Fusion Network), featuring a three-step progressive feature optimization strategy: (1) the Adjacent Feature Aggregation Module (AFAM) enhances shallow geometric details via lateral three-stage fusion to compensate for lightweight backbones; (2) the Temporal Attention Cross Module (TACM) integrates cross-level feature propagation and Convolutional Block Attention Module (CBAM) for collaborative optimization of high-level semantics and low-level details; and (3) the Efficient Guidance Module (EGM) establishes long-range dependencies using shared change priors and lightweight self-attention to suppress internal voids in changed regions. Experiments on three public datasets (LEVIR-CD, HRCUS, SYSU-ChangeDet) demonstrate that ATCFNet achieves state-of-the-art accuracy with merely 3.71 million (M) parameters and 3.0 billion (G) floating-point operations (FLOPs)—F1-scores of 91.46%, 77.05%, and 83.53%, significantly outperforming 18 existing methods in most indicators. Notably, it excels in edge integrity (avoiding jagged blurring at change boundaries) and small-target detection in high-resolution urban scenes. This study provides an efficient and reliable lightweight solution for edge computing scenarios such as real-time drone inspection and satellite on-board intelligent processing.

Against the backdrop of complex features and spectral heterogeneity in high-resolution remote sensing imagery, traditional methods suffer from insufficient semantic understanding, while existing vision–language change detection models face low efficiency, poor spatial localization, and decoupled detection–description pipelines. To overcome these limitations, this paper proposes ChangeVLM, a language-guided semantic alignment framework for binary remote sensing change detection, enabling end-to-end, prompt-free, highly efficient, and interpretable change detection. Its key advantages include the following, (1) Higher detection accuracy with F1 scores of 91.52%, 83.56%, and 75.29% on LEVIR-CD, SYSU-ChangeDet, and HRCUS datasets, outperforming 18 state-of-the-art methods. (2) Stronger edge integrity and small-object detection capability; (3) practical deployment efficiency: the end-to-end FLOPs is 560.7G. Additionally, under an optimized inference setting with pre-extracted features, the effective computation can be reduced to 13.05G. (4) Language-guided semantic regularization to enhance visual discrimination, without requiring external text prompts. The Asymmetric Fusion Module (AFM), lightweight ChangeHead, and Change-Aware Cross-Modal Fusion Module (CACMF) jointly enhance spatial precision, efficiency, and interpretability. Extensive experiments validate that ChangeVLM achieves a superior accuracy–efficiency trade-off. This method provides an effective, deployable solution for high-resolution remote sensing binary change detection, where the language branch acts only as a regularization signal.