A growing body of experimental evidence suggests that microRNAs (miRNAs) are closely associated with specific human diseases and play critical roles in their development and progression. Therefore, identifying miRNA related to specific diseases is of great significance for disease screening and treatment. In the early stages, the identification of associations between miRNAs and diseases demanded laborious and time-consuming biological experiments that often carried a substantial risk of failure. With the exponential growth in the number of potential miRNA-disease association combinations, traditional biological experimental methods face difficulties in processing massive amounts of data. Hence, developing more efficient computational methods to predict possible miRNA-disease associations and prioritize them is particularly necessary. In recent years, numerous deep learning-based computational methods have been developed and have demonstrated excellent performance. However, most of these methods rely on external databases or tools to compute various auxiliary information. Unfortunately, these external databases or tools often cover only a limited portion of miRNAs and diseases, resulting in many miRNAs and diseases being unable to match with these computational methods. Therefore, there are certain limitations associated with the practical application of these methods. To overcome the above limitations, this study proposes a multi-view computational model called MVNMDA, which predicts potential miRNA-disease associations by integrating features of miRNA and diseases from local views, global views, and semantic views. Specifically, MVNMDA utilizes known association information to construct node initial features. Then, multiple networks are constructed based on known association to extract low-dimensional feature embedding of all nodes. Finally, a cascaded attention classifier is proposed to fuse features from coarse to fine, suppressing noise within the features and making precise predictions. To validate the effectiveness of the proposed method, extensive experiments were conducted on the HMDD v2.0 and HMDD v3.2 datasets. The experimental results demonstrate that MVNMDA achieves better performance compared to other computational methods. Additionally, the case study results further demonstrate the reliable predictive performance of MVNMDA.

Crop pests seriously affect the yield and quality of crop. To timely and accurately control crop pests is particularly crucial for crop security, quality of life and a stable agricultural economy. Crop pest detection in field is an essential step to control the pests. The existing convolutional neural network (CNN) based pest detection methods are not satisfactory for small pest recognition and detection in field because the pests are various with different colors, shapes and poses. A three-scale CNN with attention (TSCNNA) model is constructed for crop pest detection by adding the channel attention and spatial mechanisms are introduced into CNN. TSCNNA can improve the interest of CNN for pest detection with different sizes under complicated background, and enlarge the receptive field of CNN, so as to improve the accuracy of pest detection. Experiments are carried out on the image set of common crop pests, and the precision is 93.16%, which is 5.1% and 3.7% higher than ICNN and VGG16, respectively. The results show that the proposed method can achieve both high speed and high accuracy of crop pest detection. This proposed method has certain practical significance of real-time crop pest control in the field.

Drug combination is very common in the course of disease treatment. However, it inevitably increases the overall risk of adverse drug reactions (ADRs). It is very important to early and accurately detect and identify the potential ADRs for combined medication safety and public health. Social media is an important pharmacovigilance data source for ADR detection. But the data are complex, mass, clutter, highly sparse, so it is difficult to detect the ADR information from these data. Deep learning stands out in terms of increased accuracy. However, it takes a lot of training time and requires a lot of computing power. Quantum computing has strong parallel computing capability, and requires less computing power. By introducing attention mechanism and quantum computing into Bi-directional Long Short-Term Memory (Bi-LSTM), a quantum Bi-LSTM with attention (QBi-LSTMA) model is constructed for ADR detection from social media big data. QBi-LSTMA is composed of 6 variable component subcircuits (VQC) stacked. Under the condition that the main topology of Bi-LSTM remains unchanged, the biases of QBi-LSTMA in input gate, forgetting gate, candidate memory unit and output gate are removed to simplify the network structure, and the weight and active value qubits of the model are used to update the network weight. The performance of the proposed method is evaluated on the SMM4H dataset, comparing with one traditional ADR detection method and three deep learning based ADR detection approaches. The experiment results show that the proposed method has great potential in ADRs detection. To the best of our knowledge, this is the first time to investigate quantum computing to detect ADRs from social media big data.

Accurate welding defect detection (WDD) of Oil/Gas pipelines (OGP) is an active and challenging task in the reliability engineering of OGPs. To solve the problems that U-Net cannot effectively extract multi-scale global context details of the image by simple skip connection, and small defects cannot be accurately detected, a WDD method of OGP by combining residual-dilated-Inception U-Net (RDIU-Net) and Transformer (RDIUTrans) is proposed. In the model, RDIU-Net is used to extract the multi-scale local features, and Transformer is utilized to model multi-scale global contextual relationships and spatial dependency. Compared with U-Net and its variants, RDIUTrans can extract the global feature and local detail features for WDD. The results on the welding defect image dataset show that RDIUTrans is effective for WDIS with the segmentation accuracy of 95.34%. It is suitable for WDD scenes with various welding defects.

Aircraft segmentation in remote sensing images (RSIs) is an important but challenging problem for both civil and military applications. U-Net and its variants are widely used in RSI detection, but they are not suitable for multi-scale aircraft segmentation in RSIs, due to the aircrafts in RSIs are relatively small with various orientations, different sizes, fuzzy illumination and shadow, obscure boundary and irregular background. To overcome this problem, a multi-scale residual U-Net with attention (MSRAU-Net) model is constructed for multi-scale aircraft segmentation in RSIs. A multi-scale convolutional module, two modified Respaths and two kinds of attention modules are designed and introduced into MSRAU-Net to extract the multi-scale feature and make the feature fusion between the contraction path and the expansion path more efficient. Different from U-Net, MSRAU-Net replaces the convolutional block of U-Net with the Inception residual block to help the U-Net architecture coordinate the features learned from aircrafts with different scales, and the residual module and attention module are introduced into the modified Respath to deepen the network layers and solve the gradient disappearing problem while extracting the more effective feature from RSIs. The experiments on the RSI dataset validate that MSRAU-Net outperforms the other networks, in particular for detecting the small aircrafts. Compared with attention U-Net and MultiMixUNet, the precision of MSRAU-Net is improved by 9.25 and 3.36, respectively.

Addressable ZnO nanowire field emitter arrays have potential application in vacuum microelectronic devices. In this study, an under-gate structure ZnO nanowire field emitter arrays were designed and successfully fabricated using microfabrication process. High density patterned ZnO nanowires were used in each pixel to minimized the screen effect and increase the emission current. Modulation of field emission current by the gate voltage was achieved.