Skeletal bone age assessment is a common clinical practice to investigate endocrinology, genetic and growth disorders of children. However, clinical interpretation and bone age analyses are time-consuming, labor intensive and often subject to inter-observer variability. This advocates the need of fully automated method for bone age assessment. We propose a regression convolutional neural network (CNN) to automatically assess the pediatric bone age from hand radiograph. Our network is specifically trained to place more attention to those bone age related regions in the X-ray images. Specifically, we first adopt the attention module to process all images and generate the coarse/fine attention maps as inputs for the regression network. Then, the regression CNN follows the supervision of the dynamic attention loss during training, thus it can estimate the bone age of the hard (or “outlier”) images more accurately. The experimental results show that our method achieves an average discrepancy of 5.2-5.3 months between clinical and automatic bone age evaluations on two large datasets. In conclusion, we propose a fully automated deep learning solution to process X-ray images of the hand for bone age assessment, with the accuracy comparable to human experts but with much better efficiency.

Accurate lesion segmentation based on endoscopy images is a fundamental task for the automated diagnosis of gastrointestinal tract (GI Tract) diseases. Previous studies usually use hand-crafted features for representing endoscopy images, while feature definition and lesion segmentation are treated as two standalone tasks. Due to the possible heterogeneity between features and segmentation models, these methods often result in sub-optimal performance. Several fully convolutional networks have been recently developed to jointly perform feature learning and model training for GI Tract disease diagnosis. However, they generally ignore local spatial details of endoscopy images, as down-sampling operations (e.g., pooling and convolutional striding) may result in irreversible loss of image spatial information. To this end, we propose a multi-scale context-guided deep network (MCNet) for end-to-end lesion segmentation of endoscopy images in GI Tract, where both global and local contexts are captured as guidance for model training. Specifically, one global subnetwork is designed to extract the global structure and high-level semantic context of each input image. Then we further design two cascaded local subnetworks based on output feature maps of the global subnetwork, aiming to capture both local appearance information and relatively high-level semantic information in a multi-scale manner. Those feature maps learned by three subnetworks are further fused for the subsequent task of lesion segmentation. We have evaluated the proposed MCNet on 1,310 endoscopy images from the public EndoVis-Ab and CVC-ClinicDB datasets for abnormal segmentation and polyp segmentation, respectively. Experimental results demonstrate that MCNet achieves 74% and 85% mean intersection over union (IoU) on two datasets, respectively, outperforming several state-of-the-art approaches in automated lesion segmentation with endoscopy images of GI Tract.

Most cutting-edge video saliency prediction models rely on spatiotemporal features extracted by 3D convolutions due to its local contextual cues acquirement ability. However, the shortage of 3D convolutions is that it cannot effectively capture long-term spatiotemporal dependencies in videos. To address this limitation, we propose a novel Transformer-based Multi-scale Feature Integration Network (TMFI-Net) for video saliency prediction, where the proposed TMFI-Net consists of a semantic-guided encoder and a hierarchical decoder. Firstly, embarking on the Transformer-based multi-level spatiotemporal features, the semantic-guided encoder enhances the features by inserting the high-level feature into each level feature via a top-down pathway and a longitudinal connection, which endows the multi-level spatiotemporal features with rich contextual information. In this way, the features are steered to give more concerns to saliency regions. Secondly, the hierarchical decoder employs a multi-dimensional attention (MA) module to elevate features along channel, temporal, and spatial dimensions jointly. Successively, the hierarchical decoder deploys a progressive decoding block to conduct an initial saliency prediction, which provides a coarse localization of saliency regions. Lastly, considering the complementarity of different saliency predictions, we integrate all initial saliency prediction results into the final saliency map. Comprehensive experimental results on four video saliency datasets firmly demonstrate that our model achieves superior performance when compared with the state-of-the-art video saliency models. The code is available at https://github.com/wusonghe/TMFI-Net.

This paper discusses the limitations of single- and two-modal salient object detection (SOD) methods and the emergence of multi-modal SOD techniques that integrate Visible, Depth, or Thermal information. However, current multi-modal methods often rely on simple fusion techniques such as addition, multiplication and concatenation, to combine the different modalities, which is ineffective for challenging scenes, such as low illumination and background messy. To address this issue, we propose a novel multi-modal feature fusion network (MFFNet) for V-D-T salient object detection, where the two key points are the triple-modal deep fusion encoder and the progressive feature enhancement decoder. The MFFNet's triple-modal deep fusion (TDF) module is designed to integrate the features of the three modalities and explore their complementarity by utilizing mutual optimization during the encoding phase. In addition, the progressive feature enhancement decoder consists of the weighted context-enhanced feature (WCF) module, region optimization (RO) module and boundary perception (BP) module to produce region-aware and contour-aware features. After that, a multi-scale fusion (MF) module is proposed to integrate these features and generate high-quality saliency maps. We conduct extensive experiments on the VDT-2048 dataset, and our results show that the proposed MFFNet outperforms 12 state-of-the-art multi-modal methods.

Segmenting breast tumors from dynamic contrast-enhanced magnetic resonance (DCE-MR) images is a critical step for early detection and diagnosis of breast cancer. However, variable shapes and sizes of breast tumors, as well as inhomogeneous background, make it challenging to accurately segment tumors in DCE-MR images. Therefore, in this article, we propose a novel tumor-sensitive synthesis module and demonstrate its usage after being integrated with tumor segmentation. To suppress false-positive segmentation with similar contrast enhancement characteristics to true breast tumors, our tumor-sensitive synthesis module can feedback differential loss of the true and false breast tumors. Thus, by following the tumor-sensitive synthesis module after the segmentation predictions, the false breast tumors with similar contrast enhancement characteristics to the true ones will be effectively reduced in the learned segmentation model. Moreover, the synthesis module also helps improve the boundary accuracy while inaccurate predictions near the boundary will lead to higher loss. For the evaluation, we build a very large-scale breast DCE-MR image dataset with 422 subjects from different patients, and conduct comprehensive experiments and comparisons with other algorithms to justify the effectiveness, adaptability, and robustness of our proposed method.