Background: ¹⁶¹Tb draws an increasing interest in nuclear medicine for therapeutic applications. More than 99% of the emitted gamma and X-rays of ¹⁶¹Tb have an energy below 100 keV. Consequently, precise activity measurement of ¹⁶¹Tb becomes inaccurate with radionuclide dose calibrators when using inappropriate containers or calibration factors to account for the attenuation of this low energy radiation. To evaluate the ionization chamber response, the sample activity must be well known. This can be performed using standards traceable to the Système International de Référence, which is briefly described as well as the method to standardize the radionuclides. Methods: In this study, the response of an ionization chamber using different container types and volumes was assessed using ¹⁶¹Tb. The containers were filled with a standardized activity solution of ¹⁶¹Tb and measured with a dedicated ionization chamber, providing an accurate response. The results were compared with standardized solutions of high-energy gamma-emitting radionuclides such as ¹³⁷Cs, ⁶⁰Co, ¹³³Ba and ⁵⁷Co. Results: For the glass vial type with an irregular glass thickness, the ¹⁶¹Tb measurements gave a deviation of 4.5% between two vials of the same type. The other glass vial types have a much more regular thickness and no discrepancy was observed in the response of the ionization chamber for these type of vials. Measurements with a plastic Eppendorf tube showed stable response, with greater sensitivity than the glass vials. Conclusion: Ionization chamber measurements for low-energy gamma emitters (< 100 keV), show deviation depending on the container type used. Therefore, a careful selection of the container type must be done for activity assessment of ¹⁶¹Tb using radionuclide dose calibrators. In conclusion, it was highlighted that appropriate calibration factors must be used for each container geometry when measuring ¹⁶¹Tb and, more generally, for low-energy gamma emitters.

⁴⁴Sc is a promising radionuclide for positron emission tomography (PET) in nuclear medicine. As a part of the implementation of a production site for ⁴⁴Sc, precise knowledge of the activity of the product is necessary. At the Paul Scherrer Institute (PSI) and the University of Bern (UniBE), ⁴⁴Sc is produced by enriched ⁴⁴CaO-target irradiation with a cyclotron. The two sites use different techniques for activity measurement, namely a dose calibrator at the PSI and a gamma-ray spectrometry system at UniBE and PSI. In this work, the ⁴⁴Sc was produced at the PSI, and samples of the product were prepared in dedicated containers for onsite measurements at PSI, UniBE, and the Institute of Radiation Physics (IRA) in Lausanne for precise activity measurement using primary techniques and for the calibration of the reference ionization chambers. An accuracy of 1% was obtained for the activity measurement, allowing for a precise calibration of the dose calibrator and gamma-ray spectrometry of the two production sites. Each production site now has the capability of measuring ⁴⁴Sc activity with an accuracy of 2%.

In this study, the gamma and X-ray emission intensities of 161Tb were determined using a high-purity germanium spectrometer. The samples used were previously standardised by coincidence counting and Triple to Double Coincidence Ratio (TDCR) methods. A total of 28 gamma-rays and 4 X-rays were measured and compared with previous measurements performed more than 30 years ago. Most of the lines are in agreement, while large discrepancies are observed for 5 lines. The uncertainties have been dramatically decreased with respect to previous measurements giving a better knowledge of the 161 Tb day.