Dr. Lucia Comez
CNR-IOM, Perugia, Umbria, Italy
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Academic Career Length
28Years (1999-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications31 May 2011 in Physical Review Letters
Journal Article
ACA. I. Chumakov
A. I. ChumakovGMG. Monaco
G. Monaco
Alfonso MonacoWCW. A. Crichton
W. A. CrichtonABA. Bosak
A. Bosak
PPP. Piekarz
P. Piekarz +14
We compare the atomic dynamics of the glass to that of the relevant crystal. In the spectra of inelastic scattering, the boson peak of the glass appears higher than the transverse acoustic (TA) singularity of the crystal. However, the density of states shows that they have the same number of states. Increasing pressure causes the transformation of the boson peak of the glass towards the TA singularity of the crystal. Once corrected for the difference in the elastic medium, the boson peak matches the TA singularity in energy and height. This suggests the identical nature of the two features.
21 July 2017 in Physical Review X
Journal Article
FSF. Scarponi
F. Scarponi
SMSara Mattana
Sara Mattana
Silvia Corezzi
Silvia CaponiLucia ComezDFDaniele FIORETTO
Daniele FIORETTO +10
Brillouin and Raman scattering spectroscopy are established techniques for the nondestructive contactless and label-free readout of mechanical, chemical, and structural properties of condensed matter. Brillouin-Raman investigations currently require separate measurements and a site-matched approach to obtain complementary information from a sample. Here, we demonstrate a new concept of fully scanning multimodal microspectroscopy for simultaneous detection of Brillouin and Raman light scattering in an exceptionally wide spectral range, from fractions of GHz to hundreds of THz. It yields an unprecedented 150-dB contrast, which is especially important for the analysis of opaque or turbid media such as biomedical samples, and spatial resolution on a subcellular scale. We report the first applications of this new multimodal method to a range of systems, from a single cell to the fast reaction kinetics of a curing process, and the mechanochemical mapping of highly scattering biological samples.
25 September 2006 in Physical Review Letters
Journal Article
Alfonso MonacoACA. I. Chumakov
A. I. ChumakovGMG. Monaco
G. Monaco
WCW. A. Crichton
W. A. CrichtonAMA. Meyer
A. Meyer
RRR. Rüffer
R. Rüffer
+3
We studied the effect of densification on the vibrational dynamics of a glass. The density of vibrational states (DOS) has been measured using nuclear inelastic scattering. The corresponding changes in the microscopic, intermediate-range, and macroscopic properties have also been investigated. The results reveal that, in the absence of local structure transformations, the Debye level and the glass-specific excess of vibrational states above it have the same dependence on density, and the evolution of the DOS is fully described by the transformation of the elastic medium.
29 April 2021 in Scientific Reports
Journal Article
LSLucia Silvestrini
Lucia SilvestriniNBNorhan Belhaj
Norhan Belhaj
Lucia ComezYGYuri Gerelli
Yuri Gerelli
ALAntonino Lauria
Antonino Lauria
FSFrancesco Spinozzi
Francesco Spinozzi +8
The maturation of coronavirus SARS-CoV-2, which is the etiological agent at the origin of the COVID-19 pandemic, requires a main protease Mproto cleave the virus-encoded polyproteins. Despite a wealth of experimental information already available, there is wide disagreement about the Mpromonomer-dimer equilibrium dissociation constant. Since the functional unit of Mprois a homodimer, the detailed knowledge of the thermodynamics of this equilibrium is a key piece of information for possible therapeutic intervention, with small molecules interfering with dimerization being potential broad-spectrum antiviral drug leads. In the present study, we exploit Small Angle X-ray Scattering (SAXS) to investigate the structural features of SARS-CoV-2 Mproin solution as a function of protein concentration and temperature. A detailed thermodynamic picture of the monomer-dimer equilibrium is derived, together with the temperature-dependent value of the dissociation constant. SAXS is also used to study how the Mprodissociation process is affected by small inhibitors selected by virtual screening. We find that these inhibitors affect dimerization and enzymatic activity to a different extent and sometimes in an opposite way, likely due to the different molecular mechanisms underlying the two processes. The Mproresidues that emerge as key to optimize both dissociation and enzymatic activity inhibition are discussed.
31 August 2004 in Physical Review B
Journal Article
FSFilippo Scarponi
Filippo Scarponi
Lucia ComezDFDaniele Fioretto
Daniele Fioretto
LPLuciano Palmieri
Luciano Palmieri
Brillouin light scattering experiments from transverse acoustic (TA) and longitudinal acoustic (LA) waves in glycerol have been performed in the temperature range between 170 and , including both the supercooled and the glassy state of the system. The intensity of light scattered by TA modes is about four orders of magnitude lower than that scattered by LA modes, giving an exceptionally low ratio of the photoelastic constants . The analysis of the frequency positions of Brillouin doublets gives a linear temperature behavior of both transverse and longitudinal elastic moduli for temperatures higher than that of the glass transition , a bend at and a less pronounced variation below . A linear relation is also found between shear and longitudinal moduli of glycerol with angular coefficient close to 3, suggesting a Cauchy-like relation to hold around .
25 March 2013 in The Journal of Physical Chemistry Letters
Journal Article
Lucia ComezLLLaura Lupi
Laura Lupi
AMAssunta Morresi
Assunta MorresiMPMarco Paolantoni
Marco PaolantoniPSPaola Sassi
Paola SassiDFDaniele Fioretto
Daniele FiorettoAbout Me
Dr. Comez graduated from the University of Perugia in 1996 and obtained a Ph.D. from the University of Camerino in 2001. She was a postdoc at the Perugia Physics Department and, in 2002, became a researcher at CNR-INFM. Since 2008, she has been a CNR-IOM researcher. From March 2016 to 2020, she headed the UOS-IOM in Perugia. Her topical scientific interests include structural and dynamical studies of glasses, hydrogels, proteins, and canonical and non-canonical DNA under different environmental conditions. She has a background as a spectroscopist and experience both in in-house techniques, such as Brillouin and Raman scattering, DLS, EDLS, CD, and UV-Vis, and in large-scale facilities around the world: ELETTRA (Italy), ESRF and ILL (France), ISIS (UK), MLZ (Germany), and Spring-8 (Japan). Has co-published about 90 peer-reviewed papers and two book chapters. Since 2017, she has been the director of the biennial workshop/school "Frontiers in Water Biophysics", which takes place in Erice, Sicily (Italy), at the Ettore Majorana Foundation and Centre for Scientific Culture. Has presented several contributions to international conferences and research centres. Is/was a tutor for several Master's and Ph.D. students. A member of the Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM) and the European Molecular Liquids Group (EMLG). Since 2014, she has been on the board of the "Ph.D. Science and Technology for Physics and Geology School" at UNIPG.