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As a chronic metabolic disease, diabetes mellitus (DM) creates a hyperglycemic micromilieu around implants, resulting inthe high complication and failure rate of implantation because of mitochondrial dysfunction in hyperglycemia. To address the daunting issue, the authors innovatively devised and developed mitochondria-targeted orthopedic implants consisted of nutrient element coatings and polyetheretherketone (PEEK). Dual nutrient elements, in the modality of ZnO and Sr(OH)2, are assembled onto the sulfonated PEEK surface (Zn&Sr-SPEEK). The results indicate the synergistic liberation of Zn2+ and Sr2+ from coating massacres pathogenic bacteria and dramatically facilitates cyto-activity of osteoblasts upon the hyperglycemic niche. Intriguingly, Zn&Sr-SPEEK implants are demonstrated to have a robust ability to recuperate hyperglycemia-induced mitochondrial dynamic disequilibrium and dysfunction by means of Dynamin-related protein 1 (Drp1) gene down-regulation, mitochondrial membrane potential (MMP) resurgence, and reactive oxygen species (ROS) elimination, ultimately enhancing osteogenicity of osteoblasts. In vivo evaluations utilizing diabetic rat femoral/tibia defect model at 4 and 8 weeks further confirm that nutrient element coatings substantially augment bone remodeling and osseointegration. Altogether, this study not only reveals the importance of Zn2+ and Sr2+ modulation on mitochondrial dynamics that contributes to bone formation and osseointegration, but also provides a novel orthopedic implant for diabetic patients with mitochondrial modulation capability.
Hao Wang; Xinliang Fu; Jiacheng Shi; Limei Li; Jiyu Sun; Xidan Zhang; Qiuyang Han; Yi Deng; Xueqi Gan. Nutrient Element Decorated Polyetheretherketone Implants Steer Mitochondrial Dynamics for Boosted Diabetic Osseointegration. Advanced Science 2021, 2101778 .
AMA StyleHao Wang, Xinliang Fu, Jiacheng Shi, Limei Li, Jiyu Sun, Xidan Zhang, Qiuyang Han, Yi Deng, Xueqi Gan. Nutrient Element Decorated Polyetheretherketone Implants Steer Mitochondrial Dynamics for Boosted Diabetic Osseointegration. Advanced Science. 2021; ():2101778.
Chicago/Turabian StyleHao Wang; Xinliang Fu; Jiacheng Shi; Limei Li; Jiyu Sun; Xidan Zhang; Qiuyang Han; Yi Deng; Xueqi Gan. 2021. "Nutrient Element Decorated Polyetheretherketone Implants Steer Mitochondrial Dynamics for Boosted Diabetic Osseointegration." Advanced Science , no. : 2101778.
Drug-free antibacterial therapy, such as photodynamic therapy and chemodynamic therapy, has become a mainstream in the treatment of implant-associated infection (IAI) due to its considerable potential on effective eradication of pathogenic bacteria via yielding overwhelming reactive oxygen species (ROS). However, superfluous ROS after therapeutical process may elicit a detrimental effect on subsequent tissue regeneration. To address this tough issue, we innovatively devise a photo-activated copper ferrite (CuFe2O4) heterojunction coating on bioinert polyetheretherketone (PEEK) implant through hydrothermal treatment and π-π-π stacking. The heterojunction coatings not only generate localized hyperthermia and ROS upon 808 nm NIR illumination, but also trigger Fenton(-like) reaction and glutathione (GSH) depletion in bacterial infectious microenvironment (IME), all leading to robust and cyclic antibacterial property through synergistic photothermal/photodynamic/chemodynamic therapy. Besides, the decorated implants are demonstrated to show superior cytocompatibility and osteogenic-promoting capability. The mice subcutaneous implantation further confirms the excellent in vivo photo-disinfection. The advantage of the heterojunction coatings lies on its enhancement in tissue generation and osteogenesis after antibacterial dynamic therapy because the liberation of micronutrient element (Cu, Fe) is significantly augmented exposed to NIR light, showing photo-enhanced osteogenicity. As envisaged, this work provides a new strategy to empower PEEK implants with an integrative feature of bacteriostasis and osteogenicity to combat intractable IAI through synergistic photo/Fenton-therapy.
Junchuan Zhang; Xiangyu Gao; Daichuan Ma; Shuai He; Bingwen Du; Weizhong Yang; Kenan Xie; Lu Xie; Yi Deng. Copper ferrite heterojunction coatings empower polyetheretherketone implant with multi-modal bactericidal functions and boosted osteogenicity through synergistic photo/Fenton-therapy. Chemical Engineering Journal 2021, 422, 130094 .
AMA StyleJunchuan Zhang, Xiangyu Gao, Daichuan Ma, Shuai He, Bingwen Du, Weizhong Yang, Kenan Xie, Lu Xie, Yi Deng. Copper ferrite heterojunction coatings empower polyetheretherketone implant with multi-modal bactericidal functions and boosted osteogenicity through synergistic photo/Fenton-therapy. Chemical Engineering Journal. 2021; 422 ():130094.
Chicago/Turabian StyleJunchuan Zhang; Xiangyu Gao; Daichuan Ma; Shuai He; Bingwen Du; Weizhong Yang; Kenan Xie; Lu Xie; Yi Deng. 2021. "Copper ferrite heterojunction coatings empower polyetheretherketone implant with multi-modal bactericidal functions and boosted osteogenicity through synergistic photo/Fenton-therapy." Chemical Engineering Journal 422, no. : 130094.
The work describes a polydopamine-wrapped zeolitic imidazolate framework-8 (ZIF-8) coating constructed on the sulfonated polyetheretherketone (PEEK). The coating is not only conducive to the controllable Zn2+ releases, but also exhibits excellent photothermal capacity under near-infrared (NIR) irradiation. in vitro antibacterial experiments indicate the coating possesses bactericidal efficiencies of 100% against Staphylococcus aureus and Escherichia coli under NIR. Without NIR, the ZIF-8/pDA-functionalized substrate shows favorable biocompatibility and enhanced osteogenic activities. We are convinced that this study may provide prospective opinions for developing the PEEK implants with photoinduced disinfection and osteogenesis for the repair of infected bone defects. Graphical Abstract
Yong Chen; Qizhang Yang; Daichuan Ma; Liming Peng; Yurong Mao; Xiong Zhou; Yi Deng; Weizhong Yang. Metal-organic frameworks/polydopamine coating endows polyetheretherketone with disinfection and osteogenicity. International Journal of Polymeric Materials and Polymeric Biomaterials 2021, 1 -12.
AMA StyleYong Chen, Qizhang Yang, Daichuan Ma, Liming Peng, Yurong Mao, Xiong Zhou, Yi Deng, Weizhong Yang. Metal-organic frameworks/polydopamine coating endows polyetheretherketone with disinfection and osteogenicity. International Journal of Polymeric Materials and Polymeric Biomaterials. 2021; ():1-12.
Chicago/Turabian StyleYong Chen; Qizhang Yang; Daichuan Ma; Liming Peng; Yurong Mao; Xiong Zhou; Yi Deng; Weizhong Yang. 2021. "Metal-organic frameworks/polydopamine coating endows polyetheretherketone with disinfection and osteogenicity." International Journal of Polymeric Materials and Polymeric Biomaterials , no. : 1-12.
Because of the explosive generation of drug-fast bacteria, antibiotics-free strategy is much-needed for elimination of bacterial-associated contagion. Herein, we develop a near-infrared (NIR) activated heterostructure catalyst (MXene/CoNWs) consisted of two-dimensional (2D) MXene and one-dimensional (1D) cobalt nanowires (CoNWs) in acting against bacteria for drug-free therapy. The intercalated CoNWs can rapidly trap the photogenerated electrons from Ti3C2 MXene nanosheets, thus restrains the recombination of hot electron-hole and facilitates transfer of carriers upon 808 nm NIR illumination, thereby increasing the yields of germicidal reactive oxygen species (ROS). Additionally, the photothermal effect of the 2D/1D heterostructure is significantly strengthened due to the synergy of plasmonic CoNWs and MXene semiconductor. The heterostructure coatings on an orthopedic implant can achieve a high antibacterial efficacy of over 90% against Gram-positive/Gram-negative bacteria within 20 min, resulting from the synergistic actions of NIR-triggered ROS and hyperthermia. Besides, in vitro findings indicate that MXene/CoNWs heterojunctions show acceptable cytocompatibility. Accordingly, the two merits make the novel MXene/CoNWs heterojunctions become a promising drug-free antibacterial therapy for cleaning the pathogenic infection and avoiding antibiotic resistance in practice.
Yunxiu Liu; Yu Tian; Qiuyang Han; Jie Yin; Junchuan Zhang; Yue Yu; Weizhong Yang; Yi Deng. Synergism of 2D/1D MXene/cobalt nanowire heterojunctions for boosted photo-activated antibacterial application. Chemical Engineering Journal 2020, 410, 128209 .
AMA StyleYunxiu Liu, Yu Tian, Qiuyang Han, Jie Yin, Junchuan Zhang, Yue Yu, Weizhong Yang, Yi Deng. Synergism of 2D/1D MXene/cobalt nanowire heterojunctions for boosted photo-activated antibacterial application. Chemical Engineering Journal. 2020; 410 ():128209.
Chicago/Turabian StyleYunxiu Liu; Yu Tian; Qiuyang Han; Jie Yin; Junchuan Zhang; Yue Yu; Weizhong Yang; Yi Deng. 2020. "Synergism of 2D/1D MXene/cobalt nanowire heterojunctions for boosted photo-activated antibacterial application." Chemical Engineering Journal 410, no. : 128209.
Polyetheretherketone (PEEK) has been well concerned as a promising material for hard tissue repair because of its outstanding mechanical behavior and superior biocompatibility. However, its clinical application is limited by its biological inertness and the susceptibility to bacterial infection during implantation. To improve the original shortcomings, self-polymerized dopamine (PDA) was used to enrich silver ions on the PEEK surface. Moreover, a layer of carboxymethyl chitosan (CMC) film was formed on the PEEK surface by the spin-coating method, aiming to control the release of silver ions on the surface. At the same time, bone forming peptide (BFP) was modified onto the PEEK surface by 1-(3-dimethylaminopropyl)-3-ethylcarbonimide hydrochloride (EDC) / N-hydroxy succinimide (NHS). The characterization results showed that PEEK-Ag-CMC-BFP could be obtained successfully. The inhibition zone and bacterial kinetic curve showed a favorable inhibitory effect of the sliver-modified PEEK on gram-negative and gram-positive bacteria. In vitro experiments exhibited that PEEK-Ag-CMC-BFP had a better biological activity than that of PEEK, which could promote cell proliferation and osteogenic differentiation. It is expected that this dual-function material with antibacterial and bone-promoting properties has a vast potential applied in the field of hard tissue repair.
Yue Yu; Yimin Sun; Xiong Zhou; Yurong Mao; Yunxiu Liu; Ling Ye; Li Kuang; Jing Yang; Yi Deng. Ag and peptide co-decorate polyetheretherketone to enhance antibacterial property and osteogenic differentiation. Colloids and Surfaces B: Biointerfaces 2020, 198, 111492 .
AMA StyleYue Yu, Yimin Sun, Xiong Zhou, Yurong Mao, Yunxiu Liu, Ling Ye, Li Kuang, Jing Yang, Yi Deng. Ag and peptide co-decorate polyetheretherketone to enhance antibacterial property and osteogenic differentiation. Colloids and Surfaces B: Biointerfaces. 2020; 198 ():111492.
Chicago/Turabian StyleYue Yu; Yimin Sun; Xiong Zhou; Yurong Mao; Yunxiu Liu; Ling Ye; Li Kuang; Jing Yang; Yi Deng. 2020. "Ag and peptide co-decorate polyetheretherketone to enhance antibacterial property and osteogenic differentiation." Colloids and Surfaces B: Biointerfaces 198, no. : 111492.
After an osteosarcoma resection, the risks of cancer recurrence, postoperative infection, and large bone loss still threaten patients' health. Conventional treatment relies on implanting orthopedic materials to fill bone defects after surgery, but it has no ability of destroying residual tumor cells and preventing bacterial invasion. To tackle this challenge, here, we develop a novel multifunctional implant ([email protected]/GelMA) that mainly consists of MXene nanosheets, gelatin methacrylate (GelMA) hydrogels, and bioinert sulfonated polyetheretherketone (SP) with the purpose of facilitating tumor cell death, combating pathogenic bacteria, and promoting osteogenicity. Because of the synergistic photothermal effects of MXene and polydopamine (pDA), osteosarcoma cells are effectively killed on the multifunctional coatings under 808 nm near-infrared (NIR) irradiation through thermal ablation. After loading tobramycin (TOB), the [email protected]/GelMA implants display robust antibacterial properties against Gram-negative/Gram-positive bacteria. More importantly, the multifunctional implants are demonstrated to have superior cytocompatibility and osteogenesis-promoting capability in terms of cell replication, spreading, alkaline phosphatase activity, calcium matrix mineralization, and in vivo osseointegration. Accordingly, such photothermally controlled multifunctional implants not only defeat osteosarcoma cells and bacteria but also intensify osteogenicity, which hold a greatly promising countermeasure for curing postoperative tissue lesion from an osteosarcoma excision.
Jie Yin; Qiuyang Han; Junchuan Zhang; Yunxiu Liu; Xueqi Gan; Kenan Xie; Lu Xie; Yi Deng. MXene-Based Hydrogels Endow Polyetheretherketone with Effective Osteogenicity and Combined Treatment of Osteosarcoma and Bacterial Infection. ACS Applied Materials & Interfaces 2020, 12, 45891 -45903.
AMA StyleJie Yin, Qiuyang Han, Junchuan Zhang, Yunxiu Liu, Xueqi Gan, Kenan Xie, Lu Xie, Yi Deng. MXene-Based Hydrogels Endow Polyetheretherketone with Effective Osteogenicity and Combined Treatment of Osteosarcoma and Bacterial Infection. ACS Applied Materials & Interfaces. 2020; 12 (41):45891-45903.
Chicago/Turabian StyleJie Yin; Qiuyang Han; Junchuan Zhang; Yunxiu Liu; Xueqi Gan; Kenan Xie; Lu Xie; Yi Deng. 2020. "MXene-Based Hydrogels Endow Polyetheretherketone with Effective Osteogenicity and Combined Treatment of Osteosarcoma and Bacterial Infection." ACS Applied Materials & Interfaces 12, no. 41: 45891-45903.
Both osteogenesis and anti-inflammatory bioactive materials play a vital role in the regeneration of skeletal defects. Bone inflammation is hard to cure and can lead to malformation or amputation. The purpose of this study is to use anti-inflammatory drugs to endow polyetheretherketone (PEEK) with the dual ability to achieve anti-inflammatory effects while maintaining favorable biocompatibility. In this experiment, the porous PEEK was immersed in an aspirin (ASP) solution after sulfonation, and the obtained porous PEEK had significantly improved the anti-inflammatory abilities. Additionally, grafting the bone forming peptide (BFP) onto the porous PEEK can distinctly enchance the osteogenesis capability. The effects of the BFP polypeptide on the proliferation of MC3T3-E1 cells and ALP activity, and the effects of aspirin on inflammation were systematically investigated. The modified material showed favorable biocompatibility and osteogenic ability. The results suggest that the combination of the BFP polypeptide with aspirin may lead to a synergetic effect on the stimulation of osteogenesis and on the reduction of inflammation.
Yue Yu; Kenan Xie; Lu Xie; Yi Deng. Endowing polyetheretherketone with anti-inflammatory ability and improved osteogenic ability. Journal of Biomaterials Science, Polymer Edition 2020, 32, 42 -59.
AMA StyleYue Yu, Kenan Xie, Lu Xie, Yi Deng. Endowing polyetheretherketone with anti-inflammatory ability and improved osteogenic ability. Journal of Biomaterials Science, Polymer Edition. 2020; 32 (1):42-59.
Chicago/Turabian StyleYue Yu; Kenan Xie; Lu Xie; Yi Deng. 2020. "Endowing polyetheretherketone with anti-inflammatory ability and improved osteogenic ability." Journal of Biomaterials Science, Polymer Edition 32, no. 1: 42-59.
Correction for ‘Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications’ by Song Wang et al., Nanoscale, 2020, 12, 11936–11946, DOI: 10.1039/D0NR02327B.
Song Wang; Chunyan Duan; Weizhong Yang; Xiangyu Gao; Jiacheng Shi; Jianping Kang; Yi Deng; Xiao-Lei Shi; Zhi-Gang Chen. Correction: Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications. Nanoscale 2020, 12, 1 .
AMA StyleSong Wang, Chunyan Duan, Weizhong Yang, Xiangyu Gao, Jiacheng Shi, Jianping Kang, Yi Deng, Xiao-Lei Shi, Zhi-Gang Chen. Correction: Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications. Nanoscale. 2020; 12 (33):1.
Chicago/Turabian StyleSong Wang; Chunyan Duan; Weizhong Yang; Xiangyu Gao; Jiacheng Shi; Jianping Kang; Yi Deng; Xiao-Lei Shi; Zhi-Gang Chen. 2020. "Correction: Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications." Nanoscale 12, no. 33: 1.
Surface modification of titanium implants by siRNA is quite efficient for improving implant osseointegration. Loading siRNA onto their surface is a crucial factor for siRNA-functionalized implants to realize their biological function. Direct binding of siRNA to implants has low siRNA binding and releasing rate, so usually it needs to be mediated by vectors. Polymeric, nonmaterial-mediated and lipid-based vectors are types of non-viral vectors which are commonly used for delivering siRNA. Three major methods of loading process, namely simple physical adsorption, layer-by-layer assembly and electrodeposition, are also summarized. A brief introduction, the basic principle and the general procedure of each method are included. The loading efficiency, which can be measured both qualitatively and quantitatively, together with gene knockdown efficiency, cytotoxicity assay and osteogenesis of the three methods are compared. A good many applications in osteogenesis have also been described in this review.
Liangrui Chen; Mingxuan Bai; Ruiyu Du; Hao Wang; Yi Deng; Anqi Xiao; Xueqi Gan. The non-viral vectors and main methods of loading siRNA onto the titanium implants and their application. Journal of Biomaterials Science, Polymer Edition 2020, 31, 2152 -2168.
AMA StyleLiangrui Chen, Mingxuan Bai, Ruiyu Du, Hao Wang, Yi Deng, Anqi Xiao, Xueqi Gan. The non-viral vectors and main methods of loading siRNA onto the titanium implants and their application. Journal of Biomaterials Science, Polymer Edition. 2020; 31 (16):2152-2168.
Chicago/Turabian StyleLiangrui Chen; Mingxuan Bai; Ruiyu Du; Hao Wang; Yi Deng; Anqi Xiao; Xueqi Gan. 2020. "The non-viral vectors and main methods of loading siRNA onto the titanium implants and their application." Journal of Biomaterials Science, Polymer Edition 31, no. 16: 2152-2168.
In order to improve the anticancer therapeutic efficacy and postoperative recovery efficacy, the novel anticancer therapeutic system should have the ability to promote angiogenesis after anticancer therapy besides the excellent anticancer therapeutic efficacy. We present herein a magnetic targeting multifunctional anticancer therapeutic system based on cobalt nanowires (CoNWs) for anticancer therapy and angiogenesis. Magnetic characterization shows that the CoNWs can be concentrated in desired locations under the external magnetic field, which is favorable for anticancer target therapy. Besides, drug loading/release characterization reveals that the CoNWs interact with doxorubicin (DOX) by electrostatic interaction, and accordingly form a composite which can release DOX with temperature increase under near-infrared light (NIR) treatment. And anticancer test reveals that the nanowires loaded with the DOX (CoNWs-DOX) can produce an effective chemo-photothermal synergistic therapeutic effect against murine breast cancer cell lines (4T1) and human osteosarcoma cell lines (MG63) under NIR treatment. Furthermore, angiogenesis assessment reveals that the released cobalt ion from the nanowires can significantly enhance the angiogenesis efficacy after cancer treatment. These results suggest that the constructed anticancer therapeutic system provides a promising multifunctional platform for cancer treatment and postoperative recovery.
Jiankui Zhao; Yunxiu Liu; Jiamin Sun; Huang Zhu; Yong Chen; Taosheng Dong; Rui Sang; Xiangyu Gao; Weizhong Yang; Yi Deng. Magnetic targeting cobalt nanowire-based multifunctional therapeutic system for anticancer treatment and angiogenesis. Colloids and Surfaces B: Biointerfaces 2020, 194, 111217 .
AMA StyleJiankui Zhao, Yunxiu Liu, Jiamin Sun, Huang Zhu, Yong Chen, Taosheng Dong, Rui Sang, Xiangyu Gao, Weizhong Yang, Yi Deng. Magnetic targeting cobalt nanowire-based multifunctional therapeutic system for anticancer treatment and angiogenesis. Colloids and Surfaces B: Biointerfaces. 2020; 194 ():111217.
Chicago/Turabian StyleJiankui Zhao; Yunxiu Liu; Jiamin Sun; Huang Zhu; Yong Chen; Taosheng Dong; Rui Sang; Xiangyu Gao; Weizhong Yang; Yi Deng. 2020. "Magnetic targeting cobalt nanowire-based multifunctional therapeutic system for anticancer treatment and angiogenesis." Colloids and Surfaces B: Biointerfaces 194, no. : 111217.
Two-dimensional (2D) MXene nanomaterials have explored as a great potential candidate for tumor therapy during recent decades, especially for photothermal therapeutic applications. However, MXene-based drug-carriers cannot be elaborately controlled in cancer therapy. To solve the problem, a heterostructured titanium carbide-cobalt nanowires (Ti3C2-CoNWs) nanocarrier is developed for synergetic anticancer with magnetic controlling ability, dual stimuli-responsive drug release, and chemo-photothermal therapy. The structure, drug loading/release behavior, magnetic controlling capacity, photothermal performance, and synergistic therapeutic efficiency of the Ti3C2-CoNWs nanocarrier heterojunction are investigated. The heterostructured Ti3C2-CoNWs nanocarrier exhibits excellent photothermal conversion efficiency under 808 nm laser irradiation and high drug loading ability (225.05%). The doxorubicin (DOX) release behavior can be triggered by acid pH value (4–6) or near-infrared (NIR) irradiation. The Ti3C2-CoNWs nanocarrier heterojunction with synergistic chemo-photothermal therapeutic effect exhibits strong lethality for cancer cells than that of chemotherapy or photothermal therapy (PTT) alone. Therefore, Ti3C2-CoNWs nanocarrier heterojunction will be a promising choice for improving the efficiency of cancer treatment.
Yunxiu Liu; Qiuyang Han; Weizhong Yang; Xueqi Gan; Yuanyi Yang; Kenan Xie; Lu Xie; Yi Deng. Two-dimensional MXene/cobalt nanowire heterojunction for controlled drug delivery and chemo-photothermal therapy. Materials Science and Engineering: C 2020, 116, 111212 .
AMA StyleYunxiu Liu, Qiuyang Han, Weizhong Yang, Xueqi Gan, Yuanyi Yang, Kenan Xie, Lu Xie, Yi Deng. Two-dimensional MXene/cobalt nanowire heterojunction for controlled drug delivery and chemo-photothermal therapy. Materials Science and Engineering: C. 2020; 116 ():111212.
Chicago/Turabian StyleYunxiu Liu; Qiuyang Han; Weizhong Yang; Xueqi Gan; Yuanyi Yang; Kenan Xie; Lu Xie; Yi Deng. 2020. "Two-dimensional MXene/cobalt nanowire heterojunction for controlled drug delivery and chemo-photothermal therapy." Materials Science and Engineering: C 116, no. : 111212.
Yi Deng; Xiuyuan Shi; Yong Chen; Weizhong Yang; Yuan Ma; Xiao-Lei Shi; Pingan Song; Matthew S. Dargusch; Zhi-Gang Chen. Bacteria-Triggered pH-Responsive Osteopotentiating Coating on 3D-Printed Polyetheretherketone Scaffolds for Infective Bone Defect Repair. Industrial & Engineering Chemistry Research 2020, 59, 12123 -12135.
AMA StyleYi Deng, Xiuyuan Shi, Yong Chen, Weizhong Yang, Yuan Ma, Xiao-Lei Shi, Pingan Song, Matthew S. Dargusch, Zhi-Gang Chen. Bacteria-Triggered pH-Responsive Osteopotentiating Coating on 3D-Printed Polyetheretherketone Scaffolds for Infective Bone Defect Repair. Industrial & Engineering Chemistry Research. 2020; 59 (26):12123-12135.
Chicago/Turabian StyleYi Deng; Xiuyuan Shi; Yong Chen; Weizhong Yang; Yuan Ma; Xiao-Lei Shi; Pingan Song; Matthew S. Dargusch; Zhi-Gang Chen. 2020. "Bacteria-Triggered pH-Responsive Osteopotentiating Coating on 3D-Printed Polyetheretherketone Scaffolds for Infective Bone Defect Repair." Industrial & Engineering Chemistry Research 59, no. 26: 12123-12135.
A multifunctional two-dimensional nanocoating consists of graphene oxide nanosheets, polydopamine nanofilm, and oligopeptide constructed on porous sulfonated polyetheretherketone for the purpose of bone infection treatment.
Song Wang; Chunyan Duan; Weizhong Yang; Xiangyu Gao; Jiacheng Shi; Jianping Kang; Yi Deng; Xiao-Lei Shi; Zhi-Gang Chen. Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications. Nanoscale 2020, 12, 11936 -11946.
AMA StyleSong Wang, Chunyan Duan, Weizhong Yang, Xiangyu Gao, Jiacheng Shi, Jianping Kang, Yi Deng, Xiao-Lei Shi, Zhi-Gang Chen. Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications. Nanoscale. 2020; 12 (22):11936-11946.
Chicago/Turabian StyleSong Wang; Chunyan Duan; Weizhong Yang; Xiangyu Gao; Jiacheng Shi; Jianping Kang; Yi Deng; Xiao-Lei Shi; Zhi-Gang Chen. 2020. "Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications." Nanoscale 12, no. 22: 11936-11946.
Polyetheretherketone (PEEK) is a biocompatible polymer, but the lack of angiogenesis makes the long-term osteogenic fixation of PEEK implants challenging, which has hampered their wider application in orthopedics. Herein, we develop a multifunctional micron/nano-structured surface presenting hydroxyapatite (HA) nanoflowers and nickel hydroxide (Ni(OH)2) nanoparticles on PEEK implants (sPEEK-Ni-HA) to tackle the problem. The results show that the reasonable release of Ni2+ from sPEEK-Ni-HA significantly facilitates the migration, tube formation and angiogenic genes expression of human umbilical vein endothelial cells (HUVECs). In addition to angiogenesis, the sPEEK-Ni-HA displays enhanced cytocompatibility and osteogenicity in terms of cell proliferation, spreading, alkaline phosphatase activity, matrix mineralization, and osteogenesis-related genes secretion, exceeding pure and other multifunctional sPEEK samples. Importantly, in vivo evaluations employing a rabbit femoral condyle implantation model confirm that such dual decoration of Ni element and HA nanoflowers boosts bone remodeling/osseointegration, which dramatically promote the in vivo osteogenic fixation of implants. Therefore, this work not only sheds light on the significance of angiogenesis on the osteogenic fixation of an implant, but also presents a facile strategy to empower bioinert PEEK with a well-orchestrated feature of angiogenesis and osteogenesis.
Taosheng Dong; Chunyan Duan; Song Wang; Xiangyu Gao; Qizhang Yang; Weizhong Yang; Yi Deng. Multifunctional Surface with Enhanced Angiogenesis for Improving Long-Term Osteogenic Fixation of Poly(ether ether ketone) Implants. ACS Applied Materials & Interfaces 2020, 12, 14971 -14982.
AMA StyleTaosheng Dong, Chunyan Duan, Song Wang, Xiangyu Gao, Qizhang Yang, Weizhong Yang, Yi Deng. Multifunctional Surface with Enhanced Angiogenesis for Improving Long-Term Osteogenic Fixation of Poly(ether ether ketone) Implants. ACS Applied Materials & Interfaces. 2020; 12 (13):14971-14982.
Chicago/Turabian StyleTaosheng Dong; Chunyan Duan; Song Wang; Xiangyu Gao; Qizhang Yang; Weizhong Yang; Yi Deng. 2020. "Multifunctional Surface with Enhanced Angiogenesis for Improving Long-Term Osteogenic Fixation of Poly(ether ether ketone) Implants." ACS Applied Materials & Interfaces 12, no. 13: 14971-14982.
Biomaterial-associated infection (BAI) is a serious threat to patient health. In general, bacteriostatic agents are loaded on the surface of biomaterials to eliminate BAI; however, the excessive usage of these agents leads to the emergence of drug-resistant bacteria and inadequacy of tissue repair. To address this issue, here, we create a photo-responsive and osteopromotive coating that consists of graphene oxide (GO) nanosheets, polydopamine (pDA) nanolayers, and adiponectin (APN) protein on bioinert sulfonated polyetheretherketone (sPEEK/GO/APN). The functionalized samples display superior cytocompatibility and in viro osteogenicity regarding cell reproduction, spreading, alkaline phosphatase activity, extracellular matrix calcification, and osteo-associated genes expression, outperforming sPEEK/GO and sPEEK/APN samples. The in vivo evaluation using a rabbit femur defect model demonstrates that the multifunctional coating significantly boosts bone regeneration and osseointegration. More importantly, the GO/pDA complex bonded together through π-π stacking and electrostatic interactions gives rise to robust cyclic photothermal bacteria-killing ability towards both Gram-positive and Gram-negative bacteria. Such a surface engineering platform may enable biomedical implants with enhanced osteogenicity ability and remotely recyclable photo-disinfection, holding great potential in the treatment of incurable infective bone loss.
Yi Deng; Xiangyu Gao; Xiao-Lei Shi; Siyu Lu; Weizhong Yang; Chunyan Duan; Zhi-Gang Chen. Graphene Oxide and Adiponectin-Functionalized Sulfonated Poly(etheretherketone) with Effective Osteogenicity and Remotely Repeatable Photodisinfection. Chemistry of Materials 2020, 32, 2180 -2193.
AMA StyleYi Deng, Xiangyu Gao, Xiao-Lei Shi, Siyu Lu, Weizhong Yang, Chunyan Duan, Zhi-Gang Chen. Graphene Oxide and Adiponectin-Functionalized Sulfonated Poly(etheretherketone) with Effective Osteogenicity and Remotely Repeatable Photodisinfection. Chemistry of Materials. 2020; 32 (5):2180-2193.
Chicago/Turabian StyleYi Deng; Xiangyu Gao; Xiao-Lei Shi; Siyu Lu; Weizhong Yang; Chunyan Duan; Zhi-Gang Chen. 2020. "Graphene Oxide and Adiponectin-Functionalized Sulfonated Poly(etheretherketone) with Effective Osteogenicity and Remotely Repeatable Photodisinfection." Chemistry of Materials 32, no. 5: 2180-2193.
A comprehensive experimental investigation of multi-scale fiber-reinforced ultra-low-weight foamed cement-based composites throughout the quasi-static uniaxial compression was presented in this work. The multi-scale hybrid fibers combinations have achieved 133% and 116% increment in compressive strength and specific strength, which were contributed to a comprehensive reinforcement in different compressive stages. This multi-scale fibers combination was deemed as desirable reinforcing elements to supplement each other. Based on a continuous constitutive damage model, the strain-softening behavior of the fiber-reinforced samples in compression was elucidated. This study has provided substantial supporting evidence for practical analysis and numerical simulation in fiber-reinforced cellular materials.
Yuanyi Yang; Qi Zhou; Yi Deng. The reinforcement attributes of multi-scale hybrid fiber throughout the uniaxial compression of ultra-low-weight foamed cement-based composites. Construction and Building Materials 2020, 242, 118184 .
AMA StyleYuanyi Yang, Qi Zhou, Yi Deng. The reinforcement attributes of multi-scale hybrid fiber throughout the uniaxial compression of ultra-low-weight foamed cement-based composites. Construction and Building Materials. 2020; 242 ():118184.
Chicago/Turabian StyleYuanyi Yang; Qi Zhou; Yi Deng. 2020. "The reinforcement attributes of multi-scale hybrid fiber throughout the uniaxial compression of ultra-low-weight foamed cement-based composites." Construction and Building Materials 242, no. : 118184.
Municipal solid waste incineration (MSWI) fly ash produced in waste-to-energy plants possesses a serious threat to human health. Although the traditional methods including toxicity characteristic leaching procedure and sequential extraction approach can partially evaluate the reduction of heavy metals leaching from thermally treated MSWI fly ash, the potential threat towards organisms is frequently ignored in previous literature. Considering this, herein we systematically assess the cytotoxicity of heat-treated samples using multiple cells from different biological tissues/organs for the first time. The results indicate that the leachability and transferability of heavy metals are declined after treatment. The biological assays demonstrate that the leachates from the treated residues induce lower phytotoxicity and cytotoxicity compared with the original samples. Moreover, according to the cellular responses of multiple cells to the leachates, normal cells (MC3T3-E1, HUVEC, and L929) are more tolerant to the leachates than cancerous cells (4T1, MG63), and the skin fibroblasts (L929), which often interact with the external circumstance, have the best cellular tolerance. This work provides a novel platform to determine the potential biosecurity of MSWI fly ash-derived products towards organisms, when they are served as secondary building materials in the constructional industry that may be contact with animals and human beings.
Yong Chen; Li Xu; Swee Ngin Tan; Xiaolong Sun; Yi Deng; Weizhong Yang. Solidification and multi-cytotoxicity evaluation of thermally treated MSWI fly ash. Journal of Hazardous Materials 2020, 388, 122041 .
AMA StyleYong Chen, Li Xu, Swee Ngin Tan, Xiaolong Sun, Yi Deng, Weizhong Yang. Solidification and multi-cytotoxicity evaluation of thermally treated MSWI fly ash. Journal of Hazardous Materials. 2020; 388 ():122041.
Chicago/Turabian StyleYong Chen; Li Xu; Swee Ngin Tan; Xiaolong Sun; Yi Deng; Weizhong Yang. 2020. "Solidification and multi-cytotoxicity evaluation of thermally treated MSWI fly ash." Journal of Hazardous Materials 388, no. : 122041.
In this study, we develop polyethylene glycol (PEG) modified nanocomposites, which structurally constitute graphene oxide (GO) and cobalt nanoparticles (CoNPs), called as the CoNPs-GO-PEG nanocomposites. These CoNPs-GO-PEG nanocomposites show better outcomes and less side effects when eliminating tumor cells. After a series of comprehensive characterizations, the CoNPs-GO-PEG nanocomposites are proved to possess pleasing targeting ability and unique drug release behavior, indicating that the concentration of the drug delivered by CoNPs-GO-PEG in the tumor site is much higher than that in the normal tissue, and concerning the favorable biocompatibility of CoNPs-GO-PEG nanocomposites, less harm is caused to normal tissue compared to traditional chemotherapy. Furthermore, because of the satisfactory photothermal effect and favorable drug release behavior of the material, the CoNPs-GO-PEG are able to eradicate most of the tumor cells (99%) through synergistic chemo-photothermal therapy in vitro. So far, our study has demonstrated an inspiring potential for the CoNPs-GO-PEG nanocomposites to act as a favorable targeting multifunctional agent in cancer therapy.
Huang Zhu; Jiuhong Deng; Zhaopu Yang; Yi Deng; Weizhong Yang; Xiao-Lei Shi; Zhi-Gang Chen. Facile synthesis and characterization of multifunctional cobalt-based nanocomposites for targeted chemo-photothermal synergistic cancer therapy. Composites Part B: Engineering 2019, 178, 107521 .
AMA StyleHuang Zhu, Jiuhong Deng, Zhaopu Yang, Yi Deng, Weizhong Yang, Xiao-Lei Shi, Zhi-Gang Chen. Facile synthesis and characterization of multifunctional cobalt-based nanocomposites for targeted chemo-photothermal synergistic cancer therapy. Composites Part B: Engineering. 2019; 178 ():107521.
Chicago/Turabian StyleHuang Zhu; Jiuhong Deng; Zhaopu Yang; Yi Deng; Weizhong Yang; Xiao-Lei Shi; Zhi-Gang Chen. 2019. "Facile synthesis and characterization of multifunctional cobalt-based nanocomposites for targeted chemo-photothermal synergistic cancer therapy." Composites Part B: Engineering 178, no. : 107521.
Zinc (Zn) material has recently become a rising biodegradable metal in orthopedic applications owing to its critical physiological functions and degradation characteristics. However, the unsatisfactory cytocompatibility due to the locally high concentration of Zn ions liberated during degradation accompanied with lack of antibacterial property and osteogenesis severely obstruct the clinical adoption of pure Zn implants. To address these challenges, we construct hierarchical ZnO nanotube/graphene oxide nanostructures (GO-An-Zn) on the pure Zn substrates via anodic oxidation followed by silk fibroin-graphene oxide self-assembly in the present study. The resultant surface displays superior bacteria-killing performances against both Gram-negative and Gram-positive bacteria. Moreover, osteoblasts on the dexamethasone-laden hierarchical micro/nanostructured Zn (GO-Dex-An-Zn) shows the enhanced cell compatibility and osteogenicity, outperforming those on pure Zn substrates. It is mainly attributed to the synergistic delivery of Zn ion and dexamethasone from bulk materials during degradation, forming a favorable microenvironment for cell survival and bone tissue remodeling. Accordingly, such work provides a novel solution to simultaneously improve the bactericidal activity and osteogenic potential of Zn-based biomaterials, bode well for their orthopedic use.
Hao Lyu; Zechao He; Yau Kei Chan; Xianhua He; Yue Yu; Yi Deng. Hierarchical ZnO Nanotube/Graphene Oxide Nanostructures Endow Pure Zn Implant with Synergistic Bactericidal Activity and Osteogenicity. Industrial & Engineering Chemistry Research 2019, 58, 19377 -19385.
AMA StyleHao Lyu, Zechao He, Yau Kei Chan, Xianhua He, Yue Yu, Yi Deng. Hierarchical ZnO Nanotube/Graphene Oxide Nanostructures Endow Pure Zn Implant with Synergistic Bactericidal Activity and Osteogenicity. Industrial & Engineering Chemistry Research. 2019; 58 (42):19377-19385.
Chicago/Turabian StyleHao Lyu; Zechao He; Yau Kei Chan; Xianhua He; Yue Yu; Yi Deng. 2019. "Hierarchical ZnO Nanotube/Graphene Oxide Nanostructures Endow Pure Zn Implant with Synergistic Bactericidal Activity and Osteogenicity." Industrial & Engineering Chemistry Research 58, no. 42: 19377-19385.
We present coalescence of liquid marbles in a non-contact approach by applying electrostatics to embedded electrodes.
Yage Zhang; Xiangyu Fu; Wei Guo; Yi Deng; Bernard P. Binks; Ho Cheung Shum; Bernie Binks. Electrocoalescence of liquid marbles driven by embedded electrodes for triggering bioreactions. Lab on a Chip 2019, 19, 3526 -3534.
AMA StyleYage Zhang, Xiangyu Fu, Wei Guo, Yi Deng, Bernard P. Binks, Ho Cheung Shum, Bernie Binks. Electrocoalescence of liquid marbles driven by embedded electrodes for triggering bioreactions. Lab on a Chip. 2019; 19 (20):3526-3534.
Chicago/Turabian StyleYage Zhang; Xiangyu Fu; Wei Guo; Yi Deng; Bernard P. Binks; Ho Cheung Shum; Bernie Binks. 2019. "Electrocoalescence of liquid marbles driven by embedded electrodes for triggering bioreactions." Lab on a Chip 19, no. 20: 3526-3534.