The daily healthy diet and balanced intake of essential nutrients play an important role in modern lifestyle. The estimation of a meal's nutrient content is an integral component of significant diseases, such as diabetes, obesity and cardiovascular disease. Lately, there has been an increasing interest towards the development and utilization of smartphone applications with the aim of promoting healthy behaviours. The semi – automatic or automatic, precise and in real-time estimation of the nutrients of daily consumed meals is approached in relevant literature as a computer vision problem using food images which are taken via a user's smartphone. Herein, we present the state-of-the-art on automatic food recognition and food volume estimation methods starting from their basis, i.e., the food image databases. First, by methodically organizing the extracted information from the reviewed studies, this review study enables the comprehensive fair assessment of the methods and techniques applied for segmenting food images, classifying their food content and computing the food volume, associating their results with the characteristics of the used datasets. Second, by unbiasedly reporting the strengths and limitations of these methods and proposing pragmatic solutions to the latter, this review can inspire future directions in the field of dietary assessment systems.

Goal : The modern way of living has significantly influenced the daily diet. The ever-increasing number of people with obesity, diabetes and cardiovascular diseases stresses the need to find tools that could help in the daily intake of the necessary nutrients. Methods: In this paper, we present an automated image-based dietary assessment system of Mediterranean food, based on: 1) an image dataset of Mediterranean foods, 2) on a pre-trained Convolutional Neural Network (CNN) for food image classification, and 3) on stereo vision techniques for the volume and nutrition estimation of the food. We use a pre-trained CNN in the Food-101 dataset to train a deep learning classification model employing our dataset Mediterranean Greek Food (MedGRFood). Based on the EfficientNet family of CNNs, we use the EfficientNetB2 both for the pre-trained model and its weights evaluation, as well as for classifying food images in the MedGRFood dataset. Next, we estimate the volume of the food, through 3D food reconstruction of two images taken by a smartphone camera. The proposed volume estimation subsystem uses stereo vision techniques and algorithms, and needs the input of two food images to reconstruct the point cloud of the food and to compute its quantity. Results: The classification accuracy where true class matches with the most probable class predicted by the model (Top-1 accuracy) is 83.8%, while the accuracy where true class matches with any one of the 5 most probable classes predicted by the model (Top-5 accuracy) is 97.6%, for the food classification subsystem. The food volume estimation subsystem achieves an overall mean absolute percentage error 10.5% for 148 different food dishes. Conclusions: The proposed automated image-based dietary assessment system provides the capability of continuous recording of health data in real time.

In this review the critical parts and milestones for data harmonization, from the biomedical engineering perspective, are outlined. The need for data sharing between heterogeneous sources pave the way for cohort harmonization; thus, fostering data integration and interdisciplinary research. Unmet needs in chronic as well as in other diseases, can be addressed based on the integration of patient health records and the sharing of information of the clinical picture and outcome. The stratification of patients, the determination of various clinical and outcome features and the identification of novel biomarkers for the different phenotypes of the disease characterize the impact of cohort harmonization in patient-centered clinical research and in precision medicine. Subsequently, the establishment of matching techniques and ontologies for the creation of data schemas are also presented. The exploitation of web technologies and data-collection tools support the opportunities to achieve new levels of integration and interoperability. Ethical and legal issues which arise when sharing and harmonizing individual-level data are discussed in order to evaluate the harmonization potential. Use cases that shape and test the harmonization approach are explicitly analyzed along with their significant results on their research objectives. Finally, future trends and directions are discussed and critically reviewed towards a roadmap in cohort harmonization for clinical medicine.

The prediction of obstructive atherosclerotic disease has significant clinical meaning for the decision making. In this study, a machine learning predictive model based on gradient boosting classifier is presented, aiming to identify the patients of high CAD risk and those of low CAD risk. The machine learning methodology includes five steps: the preprocessing of the input data, the class imbalance handling applying the Easy Ensemble algorithm, the recursive feature elimination technique implementation, the implementation of gradient boosting classifier, and finally the model evaluation, while the fine tuning of the presented model was implemented through a randomized search optimization of the model’s hyper-parameters over an internal 3-fold cross-validation. In total, 187 participants with suspicion of CAD previously underwent CTCA during EVINCI and ARTreat clinical studies and were prospectively included to undergo follow-up CTCA. The predictive model was trained using imaging data (geometrical and blood flow based) and non-imaging data. The overall predictive accuracy of the model was 0.81, using both imaging and non-imaging data. The innovative aspect of the proposed study is the combination of imaging-based data with the typical CAD risk factors to provide an integrated CAD risk-predictive model.

Gut microbiome research has made tremendous progress, especially with the integration of machine learning and artificial intelligence that can provide new insights from complex microbiome data and its impact on human health. The use of explainable artificial intelligence is becoming critical in medicine and adopting it in precision medicine-models leveraging gut microbiome data is appealing for providing more transparency and trustworthiness in clinical research. This scoping review evaluates the use of machine learning and explainable artificial intelligence techniques and identifies existing gaps in knowledge in this research area to suggest future research directions. Online databases (PubMed and Scopus) were searched to retrieve papers published between 2018-2024, and from which we selected 76 publications. Different clinical applications of machine learning and artificial intelligence techniques in gut microbiome studies were explored in the reviewed articles. We observed a high prevalence in the use of black box models in the field, with Random Forest being the most used algorithm. The explainability remains somewhat limited in the field, but it appears to be improving. Researchers showed interest in SHAP applications as an explainable technique. Finally, not enough attention was paid to the reproducibility of the research work published. This review highlights opportunities for advancing research on explainable artificial intelligence models in the field of microbiome, supporting future applications of microbiome-based precision medicine.

Background/Objectives: The prevalence of breast cancer (BC) is significant globally. The malignancy itself and the related treatments have a considerable impact on patients’ overall well-being. The adoption of e-health solutions for patients is increasing rapidly worldwide, since these innovative tools hold significant potential to positively impact the mental health and quality of life (QoL) of BC patients. However, their overall impact is still being explored, and further understanding and analysis are required. This review paper aims to present, quantify, and summarize the cumulative available randomized evidence on the state of the art of supportive interventions delivered via e-health applications for patients’ mental health and QoL before, during, and after BC treatment. Methods: A systematic review was conducted following the PRISMA guidelines in the Scopus and PubMed databases on 7 November 2024 to identify studies that utilized internet-based interventions in BC patients. The inclusion criteria were as follows: adult men and women (aged > 18 years) diagnosed with breast cancer (BC) who received patient-directed e-health interventions, compared to standard care or control interventions. The studies had to focus on outcomes such as quality of life (QoL), anxiety, depression, and distress, and be limited to randomized controlled trials (RCTs). The PRISMA-P guidelines were followed. Risk of bias was assessed using the Cochrane risk-of-bias (RoB) tool for randomized controlled trials. Results: A total of 27 randomized studies, involving 2898 patients, were included in this systematic review. The e-health interventions significantly affected patients’ anxiety (SMD = −0.80; 95% CI: −1.33 to −0.27; p < 0.01; and I² = 94%), depression (SMD = −0.74; 95% CI: −1.40 to −0.09; p = 0.026; and I² = 95%) and QoL (SMD = 0.65; 95% CI: 0.27 to 1.04; p < 0.01; and I² = 90%) but had no significant effect on distress (SMD = −0.78; 95% CI: −1.93 to 0.37; p = 0.184; and I² = 95%). Conclusions: This study showed that e-health interventions can improve QoL, reduce anxiety, and decrease depression in adult BC patients. However, no noticeable impact on reducing distress levels was observed. Additionally, given the diversity of interventions, these results should be interpreted with caution. To determine the optimum duration, validate different intervention approaches, and address methodological gaps in previous studies, more extensive clinical studies are needed.