This study explores the influence of an inclined magnetic field and variable viscosity on the entropy generation in steady flow of a couple stress fluid in an inclined channel. The walls of the channel are stationary and non-isothermal. The fluid flow is driven due to pressure gradient and gravitational force. Reynold’s model for temperature-dependent viscosity was used. The dimensionless, non-linear coupled equations of momentum and energy was solved, and we obtained an analytical solution for the velocity and temperature fields. The entropy generation and Bejan number were evaluated. The variation of pertinent parameters on flow quantities was discussed graphically. The rate of volume flow, skin friction coefficient, and Nusselt number at the surfaces of the channel were calculated and their variations were discussed through surface graphs. From the results, it is noticed that the entropy generation rate can be minimized by increasing the magnetic field and the temperature difference parameters. The findings of the current study in some special cases are in precise agreement with the previous investigation.