The purpose of this study was to investigate the influence of job satisfaction and green motivation as mediators of green human resource practices and sustainable performance in the hotel industry. In order to collect information in a quantifiable manner, a questionnaire was issued to the employees of Egypt’s five- and four-star hotels. Perspectives of 333 employees working at 18 five- and four-star hotels out of forty-four hotels located in Greater Cairo were analyzed using the partial least squares structural equation model (PLS-SEM). The results supported the model’s validity and demonstrated that green human resource practices had a beneficial effect on job satisfaction. In addition, the results suggested that job satisfaction and “green motivation” significantly contributed to sustainable performance. In addition, the results demonstrated that work satisfaction acted as a partial and full mediator between the variables of sustainable human resource practices and sustainable performance. The ramifications of theory and management are examined.