The use of biologic therapies for the management of knee osteoarthritis (OA) has largely increased in recent years. The purpose of this study was to evaluate the efficiency and the therapeutic potential of platelet-rich plasma (PRP) and autologous adipose tissue (AAT) injections as a treatment for knee OA. Sixty participants were enrolled in the study: 20 healthy ones and 40 with minimal to moderate knee OA (KL I-III). The OA patients were randomly assigned either to the PRP or to the AAT group. The PRP samples showed a low expression level of NF-κB-responsive gene CCL5 and high expression levels of classic inflammatory and TNF-l INF responses. The AAT injection product was prepared using a Lipogems device, and its regenerative potential as well as the ability for expansion of mesenchymal stem cells were tested in the cell culture conditions. The patient assessments were carried out five times. Significant improvement was observed regardless of the treatment method in the VAS, KOOS, WOMAC and IKDC 2000 subjective evaluations as well as in the functional parameters. Intra-articular injections of AAT or PRP improved pain, symptoms, quality of life and functional capacity with a comparable effectiveness in the patients with mild to moderate knee osteoarthritis.

This study aimed to evaluate the reliability of the RSQ Motion sensor and its validity against the Propriometer and electronic goniometer in measuring the active range of motion (ROM) of the shoulder. The study included 15 volunteers (mean age 24.73 ± 3.31) without any clinical symptoms with no history of trauma, disease, or surgery to the upper limb. Four movements were tested: flexion, abduction, external and internal rotation. Validation was assessed in the full range of active shoulder motion. Reliability was revised in full active ROM, a fixed angle of 90 degrees for flexion and abduction, and 45 degrees for internal and external rotation. Each participant was assessed three times: on the first day by both testers and on the second day only by one of the testers. Goniometer and RSQ Motion sensors showed moderate to excellent correlation for all tested movements (ICC 0.61–0.97, LOA < 23 degrees). Analysis of inter-rater reliability showed good to excellent agreement between both testers (ICC 0.74–0.97, LOA 13–35 degrees). Analysis of intra-rater reliability showed moderate to a good agreement (ICC 0.7–0.88, LOA 22–37 degrees). The shoulder internal and external rotation measurement with RSQ Motion sensors is valid and reliable. There is a high level of inter-rater and intra-rater reliability for the RSQ Motion sensors and Propriometer.

The invention of inertial measurement units allowed the construction of sensors suitable for human motion tracking that are more affordable than expensive optical motion capture systems, but there are a few factors influencing their accuracy, such as the calibration methods and the fusion algorithms used to translate sensor readings into angles. The main purpose of this study was to test the accuracy of a single RSQ Motion sensor in comparison to a highly precise industrial robot. The secondary objectives were to test how the type of sensor calibration affects its accuracy and whether the time and magnitude of the tested angle have an impact on the sensor’s accuracy. We performed sensor tests for nine repetitions of nine static angles made by the robot arm in eleven series. The chosen robot movements mimicked shoulder movements in a range of motion test (flexion, abduction, and rotation). The RSQ Motion sensor appeared to be very accurate, with a root-mean-square error below 0.15°. Furthermore, we found a moderate-to-strong correlation between the sensor error and the magnitude of the measured angle but only for the sensor calibrated with the gyroscope and accelerometer readings. Although the high accuracy of the RSQ Motion sensors was demonstrated in this paper, they require further study on human subjects and comparisons to the other devices known as the gold standards in orthopedics.

Background: Knee osteoarthritis (OA) is a common, chronic, progressive and degenerative disease which affects patients’ quality of life and may cause disability and social isolation. OA is a huge economic burden for the patient and a large strain for the whole healthcare system. Articular cartilage has a small potential to repair, with progressively more clinicians emphasizing cellular therapy. Subcutaneous fat tissue in human body is a large reservoir of mesenchymal stem cells (MSCs) and is been harvested in minimally invasive, simple procedure. The purpose of this study was to define a specific group of patients with knee osteoarthritis, who are the most likely to benefit from the treatment with intra-articular injection of an autologous adipose tissue (AAT). Methods: From 2016 to 2018, 59 symptomatic bilateral and unilateral knee OA patients were treated with a single intra-articular (IA) injection of an autologous adipose tissue (AAT). Before the treatment and at the follow-up, the participant was asked to fulfill the Knee Injury and Osteoarthritis Outcome Score (KOOS), the International Knee Documentation Committee 2000 (IKDC 2000), The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Health Questionnaire EQ-5D-5L and to quantify the pain in the affected joint with a Numeric Rating Scale (NRS). Moreover, the patients were asked to: (i) assess their satisfaction with the effects of the conducted treatment: from 0 (unsatisfied) to 10 (very satisfied), (ii) describe the rehabilitation, if it was performed (supervised or individual and duration in weeks) and (iii) indicate any additional treatment applied, like IA injections of hyaluronic acid (HA) or platelet-rich plasma (PRP), knee arthroscopy, partial or total knee arthroplasty (TKA) at the follow-up. Results: The mean age of 37 participants (16 males and 21 females) included into statistical analysis was 57.78 ± 7.39 years, the mean BMI was 31.30 ± 7.51. The questionnaires were fulfilled after the average follow-up time of 27 ± 6.5 months. A significant difference (p < 0.05) compared with the baseline, was observed in pain [NRS], WOMAC, KOOS index, pain, symptoms, ADL, Sport and Rec, QoL, EQ-5D-5L index. The satisfaction in the whole group was 6.16 ± 3.07. There was no significant difference between satisfied and unsatisfied patients in BMI and pain [NRS] at the baseline. 6 out of 7 patients with stage IV in K-L were unsatisfied with the effects of the treatment with AAT. Discussion: The main conclusion of this study is that the patients with stage II of the knee OA with normal BMI are were most likely to benefit from IA injection of AAT, in contrast to the patients with stage IV, who will not beware not satisfied with the effectiveness of this kind of treatment. There were no adverse events reported at the donor site as well as in the treated knee joints.

Background and objectives: The Achilles tendon, the largest tendon in the body, is vulnerable to injury because of its limited blood supply and the combination of forces to which it is subjected. Given the relevance of the Achilles tendon in the proper function of the foot and ankle, the primary goal of the present study was to use a holistic approach for a comprehensive evaluation of Achilles tendon reconstruction results on multiple levels. Materials and Methods: The study was designed in the following way: 30 patients with partial or total Achilles tendon tears were subjected to the minimally invasive Achilles tendon reconstruction. Patients were then subjected to the clinical, functional and isokinetic tests 12 and 24 months after the treatment. The clinical evaluation included calf circumference measurements and subjective patient-reported tests: ATRS, EQ-5D-5L and VAS scales. The functional evaluation was based on three tests: the weight-bearing lunge test, the heel rise test and single leg hop. Isometric and isokinetic evaluation was performed using a Biodex 3 dynamometer. Results: The calf circumference of the operated limbs was significantly lower than the non-operated limb 12 months after the surgical procedure, however this improved at the second evaluation. All subjective outcomes improved significantly 24 months after the surgery. Significantly better results in the function of the operated limbs were also obtained 24 months after the surgery. However, most of the muscle strength parameters of the operated limbs were already comparable to non-operated ones 12 months after the surgery and were comparable between two evaluation times. Conclusions: The overall results of this extensive evaluation are highly satisfactory and patients returned to their normal physical activity. From a medical point of view, it is assumed that the healing process is completed 12 months after the surgery, however, importantly, our results indicate that we should consider the healing process and the rehabilitation process separately.

Introduction Timed Up and Go test (TUG), 5 Times Sit to Stand test (STS) and 10-meter Walk test (WT) are often used in clinical trials. Aim The purpose of this study is to determine the test-retest reliability of TUG, STS, 10WT and maximal voluntary isometric contraction (MVIC) of the knee extensors and flexors and to determine a minimal detectable change (MDC) for those tests in a population of patients with knee osteoarthritis (OA) who will undergo conservative treatment. Material and methods Sixty-one patients with symptomatic knee OA were included in this study. The testing protocol consisted of TUG, STS, 10WT and maximal voluntary isometric contraction (MVIC) of knee extensors and flexors. Participants were tested twice. Results TUG, STS, 10WT and MVIC and standardised MVIC of knee extensors and flexors showed an excellent test-retest reliability. Standard Error of Measurement and MDC95 for TUG was 0.37s and 1.01s, respectively; for STS was 0.69s and 1.91s, respectively; for 10WT was 0.23s and 0.65s, respectively; for MVIC of extensors was 19.66N and 54.5N, respectively; for MVIC of flexors was 9.73N and 26.96N, respectively; for standardised MVIC of extensors was 0.22 and 0.62, respectively; for standardised MVIC of flexors was 0.11 and 0.31, respectively. Conclusions TUG, STS, 10WT, and MVIC measurements have excellent test-retest reliability in mild to moderate knee OA patients. Changes greater than 1.01s for TUG, 1.91s for STS, 0.65s for 10WT, 0.62 for standardised MVIC of knee extensors and 0.31 for standardised MVIC of knee flexors may be used as clinically significant.