Aim: To assess the efficacy of focal photocoagulation of capillary macroaneurysms (CMA) to reduce the burden of intravitreal injections (IVI) in patients with macular edema (ME). Materials and Methods: Retrospective multicenter study in patients with diabetic ME or ME secondary to retinal vein occlusion (ME-RVO). CMA associated with ME were selectively photocoagulated. Patients were followed for one year after photocoagulation. Results: 93 eyes of 76 patients were included in this study. At 6 months after the laser (n = 93), there was a significant decrease in mean macular thickness (from 354 µm to 314 µm, p < 0.001) and in mean IVI number (from 2.52 to 1.52 at 6 months, p < 0.001). The mean BCVA remained stable (0.32 and 0.31 logMAR at baseline and 6 months, p = 0.95). At 12 months (n = 81/93), there was a significant decrease in mean macular thickness (from 354 µm to 314 µm, p < 0.001) and in mean IVI number (from 4.44 to 2.95 at 12 months, p < 0.001), while the mean BCVA remained stable (0.32 and 0.30 logMAR at baseline and 12 months, p = 0.16). Conclusion: Focal laser photocoagulation of CMA seems to be effective and safe for reducing the burden of IVI in patients with ME. Their screening during the follow-up should be considered closely.

To compare refractive outcomes following bilateral implantation of three distinct extended depth-of-focus (EDOF) intraocular lens (IOL) technologies. Three EDOF IOL technologies implanted in eligible patients were assessed: non-diffractive (NDEDOF) Vivity®, bifocal refractive (REDOF) LENTIS® Comfort, diffractive (DEDOF) AT LARA®. A monofocal IOL (Clareon® Aspheric) was used as a comparator. Corrected and uncorrected distance, intermediate (IVA) and near (NVA) visual acuities were assessed at 1 and 3months. The occurrence of photic phenomena (PP) and spectacle independence were assessed at 1 and 3months using a modified McAlinden questionnaire. Ninety-two patients were analyzed. Binocular corrected distance visual acuity of 10/10 was achieved in 100% of patients in the monofocal, REDOF, and NDEDOF groups, and in 95% of the DEDOF group (P=0.98). Uncorrected intermediate and near visual acuities were better with EDOF IOLs compared to monofocal IOLs, with mean values of -0.1 and -0.2 logMAR, respectively. Photic phenomena were absent or mild (score<4/27) in 75% (NDEDOF), 78% (REDOF), 66% (DEDOF), and 91% (monofocal) of patients. The mean PP score was highest with the DEDOF lens (3.5/27, P7/15 in the monofocal group. Regardless of optical design, the EDOF IOLs provided better intermediate and near vision and greater spectacle independence compared to the monofocal IOL. Photic phenomena were generally mild, although more frequent with the diffractive design.

Iridocorneo-endothelial (ICE) syndrome is known as a rare spectrum causing glaucoma, corneal and iris damages. Retinal complications are uncommon. We report the case of a middle-aged woman suffering from a Cogan-Reese Syndrome (CRS) with refractory ocular hypertension (OHT) who presented a cystoid macular edema (CME) during follow up. We suspect the CME to be inflammatory linked to the pathophysiological hypotheses of the CRS. The CME was successfully treated with topical nonsteroidal anti-inflammatory drugs (NSAID). No consensus is available on its duration. A recurrence happened when treatment was stopped, its reintroduction was successful.