Objective: The aerial parts of Thymus satureioides have been traditionally used to treat diabetes mellitus and its complications in Morocco. The aim of the present study was to investigate the antidiabetic and antihyperlipidemic effects of the aqueous extract of Thymus satureioides aerial parts in streptozotocin (STZ) induced diabetic rats.Methods: Experimental diabetes was induced in overnight fasted rats by intraperitoneal injection of streptozotocin (45 mg/kg). Diabetic rats were orally administered with aqueous extract of Thymus satureioides (500 mg/kg b.w.) for 28 d. Glibenclamide (2 mg/kg), a standard antidiabetic drug, was used as a positive control drug. Body weight and fasting blood glucose (FGB) were measured every week. Oral glucose tolerance, change in lipid parameters, urea, creatinine, aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) levels of diabetic rats were evaluated at the end of the treatment.Results: Administration of Thymus satureioides aqueous extract to diabetic rats for 28 d reduced their fasting blood glucose levels significantly compared to the diabetic control rats. The extract improved body weight and glucose tolerance in diabetic rats. The antihyperlipidemic assessment of the extract revealed a decrease in plasma total cholesterol, triglycerides, LDL levels and an increase in HDL level in the plasma of treated diabetic rats. Furthermore, the biochemical liver and kidney functional tests have shown that serum biomarkers of liver and renal dysfunction were significantly reduced in treated diabetic rats.Conclusion: The present findings suggest that Thymus satureioides extract has both antidiabetic and antihyperlipidemic effects in experimental diabetic rats which can be beneficial in the management of diabetes and its complications.

This study reports the synthesis of 2-thioxo-1,3-dithiol-carboxamides (TDTCAs) under mild conditions at room temperature using HBTU as a coupling agent, which significantly improved amide bond formation. The synthesized compounds were characterized using several analytical techniques, including ¹H and ¹³C NMR spectroscopy, and HRMS, confirming their intended structures and structural integrity. A DFT computational study at the B3LYP/6-31G(d,p) level was conducted on the four synthesized compounds to compare their electronic properties and molecular structures. The results showed that these compounds demonstrated antispasmodic effects on jejunum contractions. Molecular docking revealed that compounds c and d displayed the highest docking scores on potassium and voltage-gated calcium channels and adrenergic receptors. In summary, compounds c and d exhibit antispasmodic effects, potentially blocking alpha-adrenergic receptors and calcium channels, thus providing a scientific basis for their potential use in treating gastrointestinal disorders.

Purpose: The purpose of this study is to compare the evolution of self-reported milk allergy in children and adults within the population of Fez-Meknes region, as well as to investigate the consumption of milk and its correlation to milk allergy.Design/methodology/approach: It is a cross-sectional study conducted in Fez-Meknes region between April 2014 and March 2015 basing on a questionnaire completed by 3,068 children and 1,281 adults.Findings: The results showed that food allergy was more reported among children (29.4 per cent) than adults (16.9 per cent). Milk allergy was reported by 5.3 per cent of children and 4.2 per cent of adults. Children reported mostly cutaneous manifestations (64.8 per cent) while adults reported mostly gastrointestinal manifestations (68.5 per cent). The consumption of milk showed a protective effect against the development of milk allergy (p< 0.001).Originality/value: The consumption of milk was associated significantly with a low rate of milk allergy, especially in adults. However, the pasteurization of milk seemed to be correlated to increase milk sensitivity.