Fungi and their natural products, like secondary metabolites, have gained a huge demand in the last decade due to their increasing applications in healthcare, environmental cleanup, and biotechnology-based industries. The fungi produce these secondary metabolites (SMs) during the different phases of their growth, which are categorized into terpenoids, alkaloids, polyketides, and non-ribosomal peptides. These SMs exhibit significant biological activity, which contributes to the formulation of novel pharmaceuticals, biopesticides, and environmental bioremediation agents. Nowadays, these fungal-derived SMs are widely used in food and beverages, for fermentation, preservatives, protein sources, and in dairy industries. In healthcare, it is being used as an antimicrobial, anticancer, anti-inflammatory, and immunosuppressive drug. The usage of modern tools of biotechnology can achieve an increase in demand for these SMs and large-scale production. The present review comprehensively analyses the diversity of fungal SMs along with their emerging applications in healthcare, agriculture, environmental sustainability, and nutraceuticals. Here, the authors have reviewed the recent advancements in genetic engineering, metabolic pathway manipulation, and synthetic biology to improve the production and yield of these SMs. Advancement in fermentation techniques, bioprocessing, and co-cultivation approaches for large-scale production of SMs. Investigators further highlighted the importance of omics technologies in understanding the regulation and biosynthesis of SMs, which offers an understanding of novel applications in drug discovery and sustainable agriculture. Finally, the authors have addressed the potential for genetic manipulation and biotechnological innovations for further exploitation of fungal SMs for commercial and environmental benefits.

Lignin is an important commercially produced polymeric material. It is used extensively in both industrial and agricultural activities. Recently, it has drawn much attention from the scientific community. It is abundantly present in nature and has significant application in the production of biodegradable materials. Its wide usage includes drug delivery, polymers and several forms of emerging lignin nanoparticles. The synthesis of lignin nanoparticles is carried out in a controlled manner. The traditional manufacturing techniques are costly and often toxic and hazardous to the environment. This review article highlights simple, safe, climate-friendly and ecological approaches to the synthesis of lignin nanoparticles. The changeable, complex structure and recalcitrant nature of lignin makes it challenging to degrade. Researchers have discovered a small number of microorganisms that have developed enzymatic and non-enzymatic metabolic pathways to use lignin as a carbon source. These microbes show promising potential for the biodegradation of lignin. The degradation pathways of these microbes are also described, which makes the study of biological synthesis much easier. However, surface modification of lignin nanoparticles is something that is yet to be explored. This review elucidates the recent advances in the biodegradation of lignin in the ecological system. It includes the current approaches, methods for modification, new applications and research for the synthesis of lignin and lignin nanoparticles. Additionally, the intricacy of lignin’s structure, along with its chemical nature, is well-described. This article will help increase the understanding of the utilization of lignin as an economical and alternative-resource material. It will also aid in the minimization of solid waste arising from lignin.

Both fossil and renewable fuel sources are used widely to produce electricity around the globe. The dependency on fossil fuels for energy leads to the depletion of reserves and various forms of pollution. Coal fly ash (CFA) is one of the most burning issues in the whole world due to its large amount of production in thermal power plants. Every year a million tons (MTs) of CFA are generated globally of which almost half is utilized in various forms, while the remaining half remains unused, leading to various types of pollution. Hence, there is an immediate requirement for CFA management approaches for the efficient and sustainable use of fly ash. In the present review, the authors emphasize the status of energy and its supply and demand. A detailed description of coal fly ash-based thermal power plants, fly ash production, and utilization is provided. Moreover, the current and emerging applications of CFA are also provided.

The Earth’s surface temperatures have increased significantly since the beginning of industrialisation. The high emissions of greenhouse gases have contributed to global warming and climate change, which is expected to continue. Here, we investigate the long-term trends of surface temperature in India using surface, satellite and reanalysis data for the period of 1980–2020, and assess the influence of geophysical drivers on temperature change using the causal discovery. The highest mean surface temperatures are observed in the southern India and the lowest in Himalaya in accordance with the incidence of solar radiation. Causal discovery reveals the relative influence of atmospheric processes, aerosols and specific humidity on surface temperature. We observe a positive trend in temperature during pre-monsoon (0.1–0.3 °C dec⁻¹) and post-monsoon (0.2–0.4 °C dec⁻¹) seasons in the northwest, northeast and north-central India. The analysis exposes high annual (0.22 ± 0.14 °C dec⁻¹) and monsoon (0.24 ± 0.08 °C dec⁻¹) warming in the northeast India. Post-monsoon season shows a positive trend in the entire India, where the highest value is estimated for the western Himalaya (0.2–0.5 °C dec⁻¹) and northeast India (0.1–0.4 °C dec⁻¹). Analyses with the Coupled Model Intercomparison Project 6 (CMIP6) results show that temperature can increase up to 1.1–5.1 °C by year 2100 under the Shared Socioeconomic Pathways (SSP5)–8.5 scenario. The increasing trend of temperature in India is a big concern, which calls for adaption and mitigation measures to alleviate adverse effects of accelerated warming and regional climate change.

Environmental pollution is becoming more prevalent in both human life and the ecosystem. The increased use of fossil fuels, mining, and the burning of wastes, as well as industrial wastewater discharge, are polluting natural resources such as water, soil, and air. Metals (loid)s (Cu, Cr, Cd, Zn, Ni, Pb, Hg, Sb, Sn, and As) contribute to several ecological problems when exposed to humans and the environment resulting in serious health and environmental risks. The pollution of aquatic and terrestrial sites with these elements is an issue of environmental as well as public health significance. The present review highlights environmental problems instigated by the toxic metal (loid)s, their source, and respective health/environmental concern along with the importance of creating low-cost, environmentally acceptable clean-up technologies for treating household and industrial wastewater. Various physical, chemical, biological, and/or biochemical as well as their various combinations have been described from the sustainable technological point of view. Techniques such as ion exchange, membrane filtration, photocatalysis, bioremediation, phytoremediation, economical biosorbents, and nanomaterials have been discussed in detail along with respective recent case studies to gain a significant inside towards the solution of the environmental problems focused and action-oriented sustainable technologies development. Thus, this article significantly provides a deep insight into metal (loid)s toxicity, source identification, and their influences on the ecosystem and human health along with conventional and sustainable clean-up technologies.