Luigi Macchitella

Dr. Luigi Macchitella

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
30 March 2023 in Behavioral Sciences
Verified
Journal Article
Open access
PDF file
LMLuigi Macchitella
Luigi Macchitella
GTGiorgia Tosi
Giorgia Tosi
DRDaniele Romano
Daniele Romano
MIMarika Iaia
Marika Iaia
FVFrancesca Vizzi
Francesca Vizzi
Paola AngelelliPaola Angelelli
Paola Angelelli
Visuo-spatial working memory is one of the main domain-general cognitive mechanisms underlying mathematical abilities and their development in children. However, if visuo-spatial working memory involves different processes and components, then the term ‘mathematics’ refers to a broad concept that includes multiple domains and skills. The aim of this present study was to investigate the relationship between different visuo-spatial working memory components and several mathematical abilities in a sample of third- to fifth-grade Italian children. To assess the relationships between different visuo-spatial working memory components and different mathematical abilities, we relied on Network Analysis (NA). Results indicate that some but not all visuo-spatial working memory components are associated with some mathematical abilities.

12 July 2023 in Neurological Sciences
Verified
Journal Article
Closed access
PDF file
VNValentina Nicolardi
Valentina Nicolardi
IFIsabella Fanizza
Isabella Fanizza
GAGiuseppe Accogli
Giuseppe Accogli
LMLuigi Macchitella
Luigi Macchitella
SSSara Scoditti
Sara Scoditti
ATAntonio Trabacca
Antonio Trabacca

13 May 2025 in Journal of Alzheimer’s Disease
Verified
Journal Article
Closed access
FGFrancesco Giaquinto
Francesco Giaquinto
MIMarika Iaia
Marika Iaia
EREzia Rizzi
Ezia Rizzi
LMLuigi Macchitella
Luigi Macchitella
DRDaniele Luigi Romano
Daniele Luigi Romano
PAPaola Angelelli
Paola Angelelli
Background: The prevalence of individuals living with mild cognitive impairment (MCI), Alzheimer's disease (AD), and other forms of dementia is globally increasing. Four out of nine international clinical guidelines recommend non-pharmacological cognitive interventions to enhance cognition, independence, and wellbeing. However, the effectiveness of cognitive rehabilitation (CR) and cognitive training (CT) for individuals with MCI and AD and other forms of dementia is still debatable, often due to significant heterogeneity among studies. Objective: This study aims to assess the effectiveness of CT and CR in these populations. Methods: Following PRISMA guidelines, we conducted a comprehensive literature search across databases including OVID, MEDLINE, EMBASE, and Scopus, identifying randomized controlled trials and non-randomized pre-post intervention studies. The Bayesian meta-analysis focused on pre-post changes in global cognition, quality of life, everyday functioning, and depression, avoiding comparisons with control groups to reduce heterogeneity (PROSPERO: CRD42022365038). Results: The search yielded 6075 results, with 40 studies meeting inclusion criteria, encompassing 50 independent trials. CT and people with AD and other dementias are the best represented intervention and population, respectively. CT was more effective in improving global cognition in individuals with AD and other dementias, and paper-and-pencil and face-to-face formats yielded greater benefits. The analysis showed a significant susceptibility to bias among the studies. Conclusions: Limitations in outcome measure (e.g., MMSE) suggest the need for more sensitive assessments, especially for MCI. Future research should explore broader aspects of wellbeing and investigate the potential of CR. Policymakers are encouraged to consider these findings when designing cognitive interventions for this population.

20 December 2024 in Applied Sciences
Verified
Journal Article
Open access
PDF file
LMLuigi Macchitella
Luigi Macchitella
GAGiuseppe Accogli
Giuseppe Accogli
GBGiulia Barraco
Giulia Barraco
VNValentina Nicolardi
Valentina Nicolardi
GPGreta Pirani
Greta Pirani
ATAntonio Trabacca
Antonio Trabacca
In recent years, extended reality (XR) and telerehabilitation (TR) technologies have increasingly been used in the neurorehabilitation of motor dysfunctions in patients with cerebral palsy (CP). The Khymeia Virtual Reality Rehabilitation System (K-VRRS) is a medical device specifically designed for neuromotor rehabilitation, and it can also be used in TR mode. This pilot study aims to evaluate the effectiveness and adherence to a “two-step neuromotor program” (TS-NP) approach using K-VRRS to enhance upper limb motor functions in children with CP. The TS-NP protocol consists of two phases. In the first phase, patients undergo intensive motor training with K-VRRS during a period of hospitalization. In the second phase, initiated after discharge, patients continue K-VRRS treatment at home through TR, building upon the progress made during their hospital stay. A total of seven children with unilateral spastic CP (ages 4–10 years) were assessed at three time points: baseline (T0), after the first phase of in-person hospital treatment (T1), and following the second phase of TR treatment at home (T2). Standardized outcome measures were used, with the primary measure being the Melbourne Assessment 2. Preliminary data support the hypothesis that intensive K-VRRS treatment during hospitalization enhances motor function in the affected upper limb of children with CP. Furthermore, continuing K-VRRS treatment at home through TR appears crucial for maintaining the motor gains achieved during the hospital phase.

23 September 2025 in Children
Verified
Journal Article
Open access
PDF file
GAGiuseppe Accogli
Giuseppe Accogli
VNValentina Nicolardi
Valentina Nicolardi
MLMariangela Leucci
Mariangela Leucci
LMLuigi Macchitella
Luigi Macchitella
GPGreta Pirani
Greta Pirani
ATAntonio Trabacca
Antonio Trabacca
Background: Time perception (TP) is increasingly recognized as a key cognitive domain in children and adolescents with cerebral palsy (CP), yet existing studies are scarce, heterogeneous, and methodologically limited. Objective: To synthesize empirical evidence on TP in pediatric CP, distinguishing perceptual timing deficits from motor-based impairments and outlining putative cognitive mechanisms. Methods: Following PRISMA where appropriate, we systematically searched Scopus, Embase, and PubMed Central for studies on TP in individuals with CP under 18 years. Four studies met inclusion criteria. Risk of bias was appraised with STROBE, AXIS, and RoB 2. Results: Available evidence suggests that TP difficulties in CP are not solely due to motor dysfunction but also reflect broader cognitive–perceptual challenges. Studies using low-motor-demand tasks sometimes report intact TP, whereas tasks requiring overt movement often confound perceptual timing with execution demands. Intervention findings are mixed: time-related supports show promising but inconsistent effects on everyday time processing, while motor-focused timing training demonstrates limited impact on TP itself. However, conclusions are constrained by the small number of studies and variability in samples, tasks, and outcomes. Conclusions: TP should be considered a distinct, clinically relevant construct in pediatric CP. Future work should employ motor-minimal paradigms, report standardized CP classifications, and adopt longitudinal designs to isolate TP deficits and guide targeted interventions. Clarifying TP profiles may improve cognitive characterization and rehabilitation planning in CP.

2 July 2024 in Journal of Neuropsychology
Verified
Journal Article
Closed access
LMLuigi Macchitella
Luigi Macchitella
SSSimona Spaccavento
Simona Spaccavento
MAMichele Arigliani
Michele Arigliani
FGFrancesco Giaquinto
Francesco Giaquinto
MTMarco Turi
Marco Turi
PAPaola Angelelli
Paola Angelelli