Automatic Leukemia or blood cancer detection is a challenging job and is very much required in healthcare centers. It has a significant role in early diagnosis and treatment planning. Leukemia is a hematological disorder that starts from the bone marrow and affects white blood cells (WBCs). Microscopic analysis of WBCs is a preferred approach for an early detection of Leukemia since it is cost-effective and less painful. Very few literature reviews have been done to demonstrate a comprehensive analysis of deep and machine learning-based Acute Lymphoblastic Leukemia (ALL) detection. This article presents a systematic review of the recent advancements in this knowledge domain. Here, various artificial intelligence-based ALL detection approaches are analyzed in a systematic manner with merits and demits. The review of these schemes is conducted in a structured manner. For this purpose, segmentation schemes are broadly categorized into signal and image processing-based techniques, conventional machine learning-based techniques, and deep learning-based techniques. Conventional machine learning-based ALL classification approaches are categorized into supervised and unsupervised machine learning is presented. In addition, deep learning-based classification methods are categorized into Convolutional Neural Network (CNN), Recurrent Neural Network (RNN), and the Autoencoder. Then, CNN-based classification schemes are further categorized into conventional CNN, transfer learning, and other advancements in CNN. A brief discussion of these schemes and their importance in ALL classification are also presented. Moreover, a critical analysis is performed to present a clear idea about the recent research in this field. Finally, various challenging issues and future scopes are discussed that may assist readers in formulating new research problems in this domain.

The automatic segmentation of blood cells for detecting hematological disorders is a crucial job. It has a vital role in diagnosis, treatment planning, and output evaluation. The existing methods suffer from the issues like noise, improper seed-point detection, and oversegmentation problems, which are solved here using a Laplacian-of-Gaussian (LoG)-based modified highboosting operation, bounded opening followed by fast radial symmetry (BOFRS)-based seed-point detection, and hybrid ellipse fitting (EF), respectively. This article proposes a novel hybrid EF-based blood-cell segmentation approach, which may be used for detecting various hematological disorders. Our prime contributions are: 1) more accurate seed-point detection based on BO-FRS; 2) a novel least-squares (LS)-based geometric EF approach; and 3) an improved segmentation performance by employing a hybridized version of geometric and algebraic EF techniques retaining the benefits of both approaches. It is a computationally efficient approach since it hybridizes noniterative-geometric and algebraic methods. Moreover, we propose to estimate the minor and major axes based on the residue and residue offset factors. The residue offset parameter, proposed here, yields more accurate segmentation with proper EF. Our method is compared with the state-of-the-art methods. It outperforms the existing EF techniques in terms of dice similarity, Jaccard score, precision, and F1 score. It may be useful for other medical and cybernetics applications.

For the early diagnosis of hematological disorders like blood cancer, microscopic analysis of blood cells is very important. Traditional deep CNNs lead to overfitting when it receives small medical image datasets such as ALLIDB1, ALLIDB2, and ASH. This paper proposes a new and effective model for classifying and detecting Acute Lymphoblastic Leukemia (ALL) or Acute Myelogenous Leukemia (AML) that delivers excellent performance in small medical datasets. Here, we have proposed a novel Orthogonal SoftMax Layer (OSL)-based Acute Leukemia detection model that consists of ResNet 18-based deep feature extraction followed by efficient OSL-based classification. Here, OSL is integrated with the ResNet18 to improve the classification performance by making the weight vectors orthogonal to each other. Hence, it integrates ResNet benefits (residual learning and identity mapping) with the benefits of OSL-based classification (improvement of feature discrimination capability and computational efficiency). Furthermore, we have introduced extra dropout and ReLu layers in the architecture to achieve a faster network with enhanced performance. The performance verification is performed on standard ALLIDB1, ALLIDB2, and $ C\_{N}MC\_{2}019$ datasets for efficient ALL detection and ASH dataset for effective AML detection. The experimental performance demonstrates the superiority of the proposed model over other compairing models.