Observation‐based and modeling studies have identified the Eastern Mediterranean and Middle East (EMME) region as a prominent climate change hotspot. While several initiatives have addressed the impacts of climate change in parts of the EMME, here we present an updated assessment, covering a wide range of timescales, phenomena and future pathways. Our assessment is based on a revised analysis of recent observations and projections and an extensive overview of the recent scientific literature on the causes and effects of regional climate change. Greenhouse gas emissions in the EMME are growing rapidly, surpassing those of the European Union, hence contributing significantly to climate change. Over the past half‐century and especially during recent decades, the EMME has warmed significantly faster than other inhabited regions. At the same time, changes in the hydrological cycle have become evident. The observed recent temperature increase of about 0.45°C per decade is projected to continue, although strong global greenhouse gas emission reductions could moderate this trend. In addition to projected changes in mean climate conditions, we call attention to extreme weather events with potentially disruptive societal impacts. These include the strongly increasing severity and duration of heatwaves, droughts and dust storms, as well as torrential rain events that can trigger flash floods. Our review is complemented by a discussion of atmospheric pollution and land‐use change in the region, including urbanization, desertification and forest fires. Finally, we identify sectors that may be critically affected and formulate adaptation and research recommendations toward greater resilience of the EMME region to climate change.

ERA5 is widely considered as a valid proxy of observation at region scales. Surface air temperature from the E-OBS database and 196 meteorological stations across Europe are being applied for evaluation of the fifth-generation ECMWF reanalysis ERA5 temperature data in the period of 1981–2010. In general, ERA5 captures the mean and extreme temperatures very well and ERA5 is reliable for climate investigation over Europe. High correlations ranging from 0.995 to 1.000 indicate that ERA5 could capture the annual cycle very well. However, the high mean biases and high Root Mean Square Error (RMSE) for some European sub-regions (e.g., the Alps, the Mediterranean) reveal that ERA5 underestimates temperatures. The biases can be mainly attributed to the altitude differences between ERA5 grid points and stations. Comparing ERA5 with the other two datasets, ERA5 temperature presents more extreme temperature and small outliers for regions southern of 40° latitude and less extreme temperatures in areas over the Black Sea. In Scandinavia, ERA5 temperatures are more frequently extreme than the observational ones.

An exceptionally cold episode occurred in January 2017 over the Balkan Peninsula. Analysis of historical records showed that it was one of the coldest extreme episodes. Even though the low temperatures of January 2017 did not break previous low records for all stations, the long duration was quite extreme, resulting in strong socioeconomic impacts in the region of interest. The 10-year to 100-year return values of minimum temperatures were calculated based on block maxima method and the maximum likelihood estimates. The estimated return periods of the absolute minimum temperature are approximately 15 or 20 years for almost all stations. For only one station, the absolute minimum temperature of January 2017 might happen once in every 300 years according to the return level results. Moreover, the extreme cold episode over the Balkans during the period of 5 January 2017 to 12 January 2017 was associated with a significant outbreak of arctic air masses into eastern–central Europe and the Balkans and a cutoff low at the level of 500 hPa over the region.

The Mediterranean Basin, renowned for its cultural, ecological, and climatic significance, frequently endures high‐impact weather events driven by Mediterranean cyclones (Medcyclones), atmospheric low‐pressure systems characterized by counterclockwise wind circulation. These meteorological phenomena, sometimes comparable to hurricanes in their intensity and impact, shape the region's weather and are responsible for diverse natural hazards, including torrential rainfall, flash floods, windstorms, and sea surges. Such events have profound and far‐reaching socio‐economic and ecological consequences, particularly for coastal and densely populated areas. Despite their critical role, the systematic assessment of Medcyclones' contribution to socio‐economic losses and the effective communication of associated risks remains limited. This review synthesizes the existing body of knowledge on the socio‐economic impacts of Medcyclones, with a focus on vulnerable sectors such as human health, energy, transportation, agriculture, and cultural heritage. It highlights pressing knowledge gaps, including the need for interdisciplinary research and improved engagement with stakeholders and the public. Advancing the field, this work provides an integrated perspective on Medcyclones' impacts and outlines strategies for resilience, including enhancing predictive models, fostering cross‐sectoral impact studies, and improving disaster preparedness. By bridging the knowledge gaps, this review aims to inform policy‐making and support the development of adaptive measures to mitigate the escalating threats posed by Medcyclones in the context of a changing climate.