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Moderation in the use of salt (sodium chloride) in food and food preparations prevents the tendency of blood pressure to increase with age, and this is documented by many studies in current literature
Massimo Lucarini; Alessandra Durazzo; Stefania Sette; Ginevra Lombardi-Boccia; Antonello Santini; Pasquale Strazzullo. Sodium Intake and Related Diseases. International Journal of Molecular Sciences 2021, 22, 7608 .
AMA StyleMassimo Lucarini, Alessandra Durazzo, Stefania Sette, Ginevra Lombardi-Boccia, Antonello Santini, Pasquale Strazzullo. Sodium Intake and Related Diseases. International Journal of Molecular Sciences. 2021; 22 (14):7608.
Chicago/Turabian StyleMassimo Lucarini; Alessandra Durazzo; Stefania Sette; Ginevra Lombardi-Boccia; Antonello Santini; Pasquale Strazzullo. 2021. "Sodium Intake and Related Diseases." International Journal of Molecular Sciences 22, no. 14: 7608.
Medicinal plants always are part of folk medicine and are nowadays receiving worldwide attention for prophylaxis, management, and treatment of several diseases, as an alternative to chemical drugs. The current work provided a comprehensive overview and analysis of the Astragalus and health relationship in literature. The analysis of their therapeutic potential is thus instrumental to understand their bioactivity. Among these, the flowering medicinal plant Astragalus membranaceus has raised interest due to several beneficial health effects. This perspective review discussed the botanical, geographical, historical, and the therapeutic properties of A. membranaceus, with a special focus on its health improving effects and medicinal applications both in vitro and in vivo. Graphic abstract
Alessandra Durazzo; Amirhossein Nazhand; Massimo Lucarini; Amelia M. Silva; Selma B. Souto; Fabrizia Guerra; Patricia Severino; Massimo Zaccardelli; Eliana B. Souto; Antonello Santini. Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role. Rendiconti Lincei. Scienze Fisiche e Naturali 2021, 1 -18.
AMA StyleAlessandra Durazzo, Amirhossein Nazhand, Massimo Lucarini, Amelia M. Silva, Selma B. Souto, Fabrizia Guerra, Patricia Severino, Massimo Zaccardelli, Eliana B. Souto, Antonello Santini. Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role. Rendiconti Lincei. Scienze Fisiche e Naturali. 2021; ():1-18.
Chicago/Turabian StyleAlessandra Durazzo; Amirhossein Nazhand; Massimo Lucarini; Amelia M. Silva; Selma B. Souto; Fabrizia Guerra; Patricia Severino; Massimo Zaccardelli; Eliana B. Souto; Antonello Santini. 2021. "Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role." Rendiconti Lincei. Scienze Fisiche e Naturali , no. : 1-18.
The relationship between wine polyphenols and health has been receiving growing scientific attention in the last few years. To confirm this point, the proposed paper identifies the major contributors to academic journals regarding the relationships between wine polyphenols and health. The endpoints of the proposed study are to provide a comprehensive overview and analysis of the literature regarding the relationships between wine polyphenol and health based on a bibliometric analysis. Bibliometric data were extracted from the Scopus online database using the search string TITLE-ABS-KEY (wine AND polyphenol* AND health OR (“french paradox” OR “cardiovascular disease*” OR atherosclerosis OR microbiota) and analyzed using the VOSviewer bibliometric software to generate bubble maps and to visualize the obtained results. This perspective paper analyzes: (i) the research themes addressing the relationships between wine polyphenols and health; (ii) the major contributors’ origin, e.g., country and/or regions; (iii) the institutions where the research is based; (iv) the authors; and (v) the type of paper. These results represent a useful tool to identify emerging research directions, collaboration networks, and suggestions for more in-depth literature searches.
Massimo Lucarini; Alessandra Durazzo; Ginevra Lombardi-Boccia; Eliana Souto; Francesca Cecchini; Antonello Santini. Wine Polyphenols and Health: Quantitative Research Literature Analysis. Applied Sciences 2021, 11, 4762 .
AMA StyleMassimo Lucarini, Alessandra Durazzo, Ginevra Lombardi-Boccia, Eliana Souto, Francesca Cecchini, Antonello Santini. Wine Polyphenols and Health: Quantitative Research Literature Analysis. Applied Sciences. 2021; 11 (11):4762.
Chicago/Turabian StyleMassimo Lucarini; Alessandra Durazzo; Ginevra Lombardi-Boccia; Eliana Souto; Francesca Cecchini; Antonello Santini. 2021. "Wine Polyphenols and Health: Quantitative Research Literature Analysis." Applied Sciences 11, no. 11: 4762.
Many plants have been known for centuries to have medicinal importance with potential beneficial effects on health. Phytotherapeutic compounds are well known to play a globally significant role, in particular in the management and treatment of various chronic diseases. Among these, diabetes can cause long term damage to the body other than having a relevant economic burden on society being among the costliest chronic diseases. This motivated the focus of the proposed Special Issue, intended to develop and exploit the potential role of plants in the management and treatment of diabetes. The main topics included are: (i) description and use of medicinal plants for diabetes management; (ii) the elucidation and delineation of their main components, properties (anti-hyperglycaemic, hypoglicaemic, anti-infiammatory, apoptotic agents, etc.), (iii) the mechanism of action (in vitro and in vivo studies); (iv) formulation of nutraceuticals, botanicals, and dietary supplements useful as tools as an alternative or support to anti-diabetic pharmacological therapies; (v) development of new markers.
Alessandra Durazzo; Massimo Lucarini; Antonello Santini. Plants and Diabetes: Description, Role, Comprehension and Exploitation. International Journal of Molecular Sciences 2021, 22, 3938 .
AMA StyleAlessandra Durazzo, Massimo Lucarini, Antonello Santini. Plants and Diabetes: Description, Role, Comprehension and Exploitation. International Journal of Molecular Sciences. 2021; 22 (8):3938.
Chicago/Turabian StyleAlessandra Durazzo; Massimo Lucarini; Antonello Santini. 2021. "Plants and Diabetes: Description, Role, Comprehension and Exploitation." International Journal of Molecular Sciences 22, no. 8: 3938.
Tocols are present in various foods, mostly in fruits and in plant seeds. Edible oils are the most important natural dietary sources of tocopherols and tocotrienols, collectively known as tocols. Tocopherols and tocotrienols are considered beneficial for their antioxidant effect which impacts on prevention of different health conditions. This perspective is addressed to give an updated picture of the tocol occurrence in foods. Moreover, the current state of the art of tocols in updated databases is explored and commented outlining their importance and future trends.
Alessandra Durazzo; Amirhossein Nazhand; Massimo Lucarini; Amélia M. Delgado; Maryna De Wit; Kar Lin Nyam; Antonello Santini; Mohamed Fawzy Ramadan. Occurrence of Tocols in Foods: An Updated Shot of Current Databases. Journal of Food Quality 2021, 2021, 1 -7.
AMA StyleAlessandra Durazzo, Amirhossein Nazhand, Massimo Lucarini, Amélia M. Delgado, Maryna De Wit, Kar Lin Nyam, Antonello Santini, Mohamed Fawzy Ramadan. Occurrence of Tocols in Foods: An Updated Shot of Current Databases. Journal of Food Quality. 2021; 2021 ():1-7.
Chicago/Turabian StyleAlessandra Durazzo; Amirhossein Nazhand; Massimo Lucarini; Amélia M. Delgado; Maryna De Wit; Kar Lin Nyam; Antonello Santini; Mohamed Fawzy Ramadan. 2021. "Occurrence of Tocols in Foods: An Updated Shot of Current Databases." Journal of Food Quality 2021, no. : 1-7.
Forest ecosystems are an important biodiversity environment resource for many species. Forests and trees play a key role in food production and have relevant impact also on nutrition. Plants and animals in the forests make available nutrient-rich food sources, and can give an important contributions to dietary diversity, quality, and quantity. In this context, the Special Issue, entitled “Forest, Food and Nutrition”, is focused on the understanding of the intersection and linking existing between forests, food, and nutrition.
Alessandra Durazzo; Massimo Lucarini; Massimo Zaccardelli; Antonello Santini. Forest, Foods, and Nutrition. Forests 2020, 11, 1182 .
AMA StyleAlessandra Durazzo, Massimo Lucarini, Massimo Zaccardelli, Antonello Santini. Forest, Foods, and Nutrition. Forests. 2020; 11 (11):1182.
Chicago/Turabian StyleAlessandra Durazzo; Massimo Lucarini; Massimo Zaccardelli; Antonello Santini. 2020. "Forest, Foods, and Nutrition." Forests 11, no. 11: 1182.
The antioxidant properties of foods are crucial in nutrition, food chemistry, and medicine studies but are often underestimated, with significant amounts of bioactive compounds containing physiological and biochemical properties remaining in the residue from extraction as non-extractable antioxidants. Over the last decade, extractable and non-extractable compounds have become key in the evaluation/determination of the antioxidant properties of food matrices because of their relevance in human health. This has led to the need to include extractable and non-extractable antioxidants in comprehensive and harmonized food composition databases for a wide range of applications within research, food, pharmaceutical, nutraceutical, and cosmeceutical areas. Additionally, the databases are invaluable as part of the health claims application process. eBASIS, (Bioactive Substances in Food Information System) a comprehensive database containing quality-evaluated scientific data, covering the composition of bioactive compounds present in foods, has flexible structures, allowing it to be extended to include newly emerging data on extractable and non-extractable compounds. Search criteria were developed and defined for compiling suitable peer-reviewed literature. Data quality assessment methods were established for the addition of composition data and antioxidant activity, with a focus on various parameters including: the extraction procedure, the antioxidant measurements, the expression of results. A total of 437 quality-evaluated datapoints on the composition of extractable and/or non-extractable compounds were entered into the database. This database update represents one of the first examples of building a database dedicated to antioxidant properties. This expansion of eBASIS provides a novel and unique tool for nutritionists, dietitians, researchers to use for a wide range of applications, such as dietary assessment, exposure studies and epidemiological studies, and may contribute to an increase in high-bioactive food consumption by consumers.
Jenny Plumb; Alessandra Durazzo; Massimo Lucarini; Emanuela Camilli; Aida Turrini; Luisa Marletta; Paul Finglas. Extractable and Non-Extractable Antioxidants Composition in the eBASIS Database: A Key Tool for Dietary Assessment in Human Health and Disease Research. Nutrients 2020, 12, 3405 .
AMA StyleJenny Plumb, Alessandra Durazzo, Massimo Lucarini, Emanuela Camilli, Aida Turrini, Luisa Marletta, Paul Finglas. Extractable and Non-Extractable Antioxidants Composition in the eBASIS Database: A Key Tool for Dietary Assessment in Human Health and Disease Research. Nutrients. 2020; 12 (11):3405.
Chicago/Turabian StyleJenny Plumb; Alessandra Durazzo; Massimo Lucarini; Emanuela Camilli; Aida Turrini; Luisa Marletta; Paul Finglas. 2020. "Extractable and Non-Extractable Antioxidants Composition in the eBASIS Database: A Key Tool for Dietary Assessment in Human Health and Disease Research." Nutrients 12, no. 11: 3405.
The feasibility of exploiting secondary raw materials from marine food-chains as a source of molecules of nutritional interest, to create high-value food products and to meet nutritional challenges, is described in this report. A reduction in food waste is urgent as many sectors of the food industry damage the environment by depleting resources and by generating waste that must be treated. The project herein described, deals with the recovery of natural molecules, omega-3 fatty acids (EPA, DHA) and of α-tocopherol, from fish processing by-products. This would promote the sustainable development of new food products for human nutrition, as well as nutraceuticals. The growing awareness of increasing omega-3 fatty acids intake, has focused attention on the importance of fish as a natural source of these molecules in the diet. Therefore, a study on the concentration of these bioactive compounds in such matrices, as well as new green methodologies for their recovery, are necessary. This would represent an example of a circular economy process applied to the seafood value chain. Fish processing by-products, so far considered as waste, can hopefully be reutilized as active ingredients into food products of high added-value, thus maximizing the sustainability of fish production.
Massimo Lucarini; Antonio Zuorro; Gabriella Di Lena; Roberto Lavecchia; Alessandra Durazzo; Barbara Benedetti; Ginevra Lombardi-Boccia. Sustainable Management of Secondary Raw Materials from the Marine Food-Chain: A Case-Study Perspective. Sustainability 2020, 12, 8997 .
AMA StyleMassimo Lucarini, Antonio Zuorro, Gabriella Di Lena, Roberto Lavecchia, Alessandra Durazzo, Barbara Benedetti, Ginevra Lombardi-Boccia. Sustainable Management of Secondary Raw Materials from the Marine Food-Chain: A Case-Study Perspective. Sustainability. 2020; 12 (21):8997.
Chicago/Turabian StyleMassimo Lucarini; Antonio Zuorro; Gabriella Di Lena; Roberto Lavecchia; Alessandra Durazzo; Barbara Benedetti; Ginevra Lombardi-Boccia. 2020. "Sustainable Management of Secondary Raw Materials from the Marine Food-Chain: A Case-Study Perspective." Sustainability 12, no. 21: 8997.
This perspective study addresses the main causes of adverse reactions to foods in humans, by taking into account the main allergic reactions that may occur as a result of food ingestion, as well the main allergens present in food and how their allergenicity change as a result of food preparation. In addition, European legislation on food labeling and novel foods was taken into account. The case study of this perspective is on the potential allergenicity of edible flowers as well as evidence of phytochemistry and toxic compounds and the risk associated with their ingestion. Regarding edible flowers, a key issue to address is if they are safe to consume or not. In the framework of the project “Innovative activities for the development of the cross-border supply chain of the edible flower” (ANTEA), we considered 62 different species and varieties of edible flowers. The results obtained by consulting two databases on allergens, COMPRISE and Allergen Nomenclature, marked two alerts for two species of edible flowers selected in the project. Moreover, based on edible flower consumption, about ten grams per serving, and on their protein content, we can also state that the risk of allergic reactions due to edible flower ingestion is very low.
Massimo Lucarini; Andrea Copetta; Alessandra Durazzo; Paolo Gabrielli; Ginevra Lombardi-Boccia; Elisabetta Lupotto; Antonello Santini; Barbara Ruffoni. A Snapshot on Food Allergies: A Case Study on Edible Flowers. Sustainability 2020, 12, 8709 .
AMA StyleMassimo Lucarini, Andrea Copetta, Alessandra Durazzo, Paolo Gabrielli, Ginevra Lombardi-Boccia, Elisabetta Lupotto, Antonello Santini, Barbara Ruffoni. A Snapshot on Food Allergies: A Case Study on Edible Flowers. Sustainability. 2020; 12 (20):8709.
Chicago/Turabian StyleMassimo Lucarini; Andrea Copetta; Alessandra Durazzo; Paolo Gabrielli; Ginevra Lombardi-Boccia; Elisabetta Lupotto; Antonello Santini; Barbara Ruffoni. 2020. "A Snapshot on Food Allergies: A Case Study on Edible Flowers." Sustainability 12, no. 20: 8709.
As an immune-privileged target organ, the eyes have important superficial and internal barriers, protecting them from physical and chemical damage from exogenous and/or endogenous origins that would cause injury to visual acuity or even vision loss. These anatomic, physiological and histologic barriers are thus a challenge for drug access and entry into the eye. Novel therapeutic concepts are highly desirable for eye treatment. The design of an efficient ocular drug delivery system still remains a challenge. Although nanotechnology may offer the ability to detect and treat eye diseases, successful treatment approaches are still in demand. The growing interest in nanopharmaceuticals offers the opportunity to improve ophthalmic treatments. Besides their size, which needs to be critically monitored, nanopharmaceuticals for ophthalmic applications have to be produced under sterilized conditions. In this work, we have revised the different sterilization and depyrogenation methods for ophthalmic nanopharmaceuticals with their merits and drawbacks. The paper also describes clinical sterilization of drugs and the outcomes of inappropriate practices, while recent applications of nanopharmaceuticals for ocular drug delivery are also addressed.
Aleksandra Zielińska; Beatriz B. Soles; Ana R. Lopes; Beatriz F. Vaz; Camila M. Rodrigues; Thais F. R. Alves; Dorota Klensporf-Pawlik; Alessandra Durazzo; Massimo Lucarini; Patricia Severino; Antonello Santini; Marco V. Chaud; Eliana B. Souto. Nanopharmaceuticals for Eye Administration: Sterilization, Depyrogenation and Clinical Applications. Biology 2020, 9, 336 .
AMA StyleAleksandra Zielińska, Beatriz B. Soles, Ana R. Lopes, Beatriz F. Vaz, Camila M. Rodrigues, Thais F. R. Alves, Dorota Klensporf-Pawlik, Alessandra Durazzo, Massimo Lucarini, Patricia Severino, Antonello Santini, Marco V. Chaud, Eliana B. Souto. Nanopharmaceuticals for Eye Administration: Sterilization, Depyrogenation and Clinical Applications. Biology. 2020; 9 (10):336.
Chicago/Turabian StyleAleksandra Zielińska; Beatriz B. Soles; Ana R. Lopes; Beatriz F. Vaz; Camila M. Rodrigues; Thais F. R. Alves; Dorota Klensporf-Pawlik; Alessandra Durazzo; Massimo Lucarini; Patricia Severino; Antonello Santini; Marco V. Chaud; Eliana B. Souto. 2020. "Nanopharmaceuticals for Eye Administration: Sterilization, Depyrogenation and Clinical Applications." Biology 9, no. 10: 336.
The current study aimed to identify which natural products and which research directions are related to the major contributors to academic journals for diabetes therapy. Bibliometric data were extracted from the Web of Science online database using the search string TOPIC = (''natural product*' OR ''natural compound*' OR ''natural molecule*' OR 'phytochemical*' OR ''secondary metabolite*') AND TS = ('diabet*') and analysed by a bibliometric software, VOSviewer. The search yielded 3694 publications, which were collectively cited 80,791 times, with an H-index of 117 and 21.9 citations per publication on average. The top-contributing countries were India, the USA, China, South Korea and Brazil. Curcumin, flavanone, resveratrol, carotenoid, polyphenols, flavonol, flavone and berberine were the most frequently cited natural products or compound classes. Our results provide a brief overview of the major directions of natural product research in diabetes up to now and hint on promising avenues for future research.
Andy Wai Kan Yeung; Nikolay T. Tzvetkov; Alessandra Durazzo; Massimo Lucarini; Eliana B. Souto; Antonello Santini; Ren-You Gan; Artur Jozwik; Weronika Grzybek; Jarosław O. Horbańczuk; Andrei Mocan; Javier Echeverría; Dongdong Wang; Atanas G. Atanasov. Natural products in diabetes research: quantitative literature analysis. Natural Product Research 2020, 1 -15.
AMA StyleAndy Wai Kan Yeung, Nikolay T. Tzvetkov, Alessandra Durazzo, Massimo Lucarini, Eliana B. Souto, Antonello Santini, Ren-You Gan, Artur Jozwik, Weronika Grzybek, Jarosław O. Horbańczuk, Andrei Mocan, Javier Echeverría, Dongdong Wang, Atanas G. Atanasov. Natural products in diabetes research: quantitative literature analysis. Natural Product Research. 2020; ():1-15.
Chicago/Turabian StyleAndy Wai Kan Yeung; Nikolay T. Tzvetkov; Alessandra Durazzo; Massimo Lucarini; Eliana B. Souto; Antonello Santini; Ren-You Gan; Artur Jozwik; Weronika Grzybek; Jarosław O. Horbańczuk; Andrei Mocan; Javier Echeverría; Dongdong Wang; Atanas G. Atanasov. 2020. "Natural products in diabetes research: quantitative literature analysis." Natural Product Research , no. : 1-15.
The natural tridecapeptide neurotensin has been emerged as a promising therapeutic scaffold for the treatment of neurological diseases and cancer. In this work, we aimed to identify the top 100 most cited original research papers as well as recent key studies related to neurotensins. The Web of Science Core Collection database was searched and the retrieved research articles were analyzed by using the VOSviewer software. The most cited original articles were published between 1973 and 2013. The top-cited article was by Carraway and Leeman reporting the discovery of neurotensin in 1973. The highly cited terms were associated with hypotension and angiotensin-converting-enzyme. The conducted analysis reveals the therapeutic potentials of neurotensin, and further impactful research toward its clinical development is warrantied.
Andy Wai Kan Yeung; Maya G Georgieva; Kiril Kirilov; Aneliya A Balacheva; Martina I Peeva; Olaf K Horbańczuk; Jarosław O Horbańczuk; Massimo Lucarini; Alessandra Durazzo; Antonello Santini; Eliana B Souto; Tamara I Pajpanova; Luigi Milella; Atanas G Atanasov; Nikolay T Tzvetkov. Neurotensins and their therapeutic potential: research field study. Future Medicinal Chemistry 2020, 12, 1779 -1803.
AMA StyleAndy Wai Kan Yeung, Maya G Georgieva, Kiril Kirilov, Aneliya A Balacheva, Martina I Peeva, Olaf K Horbańczuk, Jarosław O Horbańczuk, Massimo Lucarini, Alessandra Durazzo, Antonello Santini, Eliana B Souto, Tamara I Pajpanova, Luigi Milella, Atanas G Atanasov, Nikolay T Tzvetkov. Neurotensins and their therapeutic potential: research field study. Future Medicinal Chemistry. 2020; 12 (19):1779-1803.
Chicago/Turabian StyleAndy Wai Kan Yeung; Maya G Georgieva; Kiril Kirilov; Aneliya A Balacheva; Martina I Peeva; Olaf K Horbańczuk; Jarosław O Horbańczuk; Massimo Lucarini; Alessandra Durazzo; Antonello Santini; Eliana B Souto; Tamara I Pajpanova; Luigi Milella; Atanas G Atanasov; Nikolay T Tzvetkov. 2020. "Neurotensins and their therapeutic potential: research field study." Future Medicinal Chemistry 12, no. 19: 1779-1803.
The essential oil from Croton argyrophyllus Kunth is known for its antiproliferative, anti-inflammatory, antinociceptive, and anticancer activities, and is recognized as a source of phytochemicals for potential use in pharmaceutic and food sectors. Solid lipid nanoparticles (SLN) have been produced to load Croton argyrophyllus (CA) Kunth essential oil (CAEO) and its antioxidant properties evaluated in vitro as a new approach for the treatment of neurodegenerative diseases. Cetyl palmitate SLN loading CAEO (CAEO-SLN) with a mean particle size of 201.4 ± 2.3 nm (polydispersity index 0.211) have been produced by hot high-pressure homogenisation. The release of the oil followed the Korsmeyers-Peppas model. The risk of lipid peroxidation has been determined by applying the production of thiobarbituric acid-reactive substances (TBARS) standard assay. The antioxidant activity was determined by the capacity of the antioxidants existing in CAEO to scavenge the stable radical DPPH•. The cytotoxicity of CA Kunth essential oil-loaded SLN (CAEO-SLN) was evaluated in a human cell line SH-SY5Y (derived from human neuroblastoma) by determining the reduction of the yellow dye 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT). Both free essential oil (fEO) and loaded essential oil (CAEO-SLN) were demonstrated to inhibit the Fenton reaction. CAEO-SLN showed DPPH• radical scavenging capacity. The loading of the oil into cetyl palmitate SLN reduced the risk of cytotoxicity.
Eliana Souto; Patricia Severino; Conrado Marques; Luciana Andrade; Alessandra Durazzo; Massimo Lucarini; Atanas Atanasov; Soukaina El Maimouni; Ettore Novellino; Antonello Santini. Croton argyrophyllus Kunth Essential Oil-Loaded Solid Lipid Nanoparticles: Evaluation of Release Profile, Antioxidant Activity and Cytotoxicity in a Neuroblastoma Cell Line. Sustainability 2020, 12, 7697 .
AMA StyleEliana Souto, Patricia Severino, Conrado Marques, Luciana Andrade, Alessandra Durazzo, Massimo Lucarini, Atanas Atanasov, Soukaina El Maimouni, Ettore Novellino, Antonello Santini. Croton argyrophyllus Kunth Essential Oil-Loaded Solid Lipid Nanoparticles: Evaluation of Release Profile, Antioxidant Activity and Cytotoxicity in a Neuroblastoma Cell Line. Sustainability. 2020; 12 (18):7697.
Chicago/Turabian StyleEliana Souto; Patricia Severino; Conrado Marques; Luciana Andrade; Alessandra Durazzo; Massimo Lucarini; Atanas Atanasov; Soukaina El Maimouni; Ettore Novellino; Antonello Santini. 2020. "Croton argyrophyllus Kunth Essential Oil-Loaded Solid Lipid Nanoparticles: Evaluation of Release Profile, Antioxidant Activity and Cytotoxicity in a Neuroblastoma Cell Line." Sustainability 12, no. 18: 7697.
Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.
Aleksandra Zielińska; Filipa Carreiró; Ana Oliveira; Andreia Neves; Bárbara Pires; D. Venkatesh; Alessandra Durazzo; Massimo Lucarini; Piotr Eder; Amélia Silva; Antonello Santini; Eliana Souto. Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology. Molecules 2020, 25, 3731 .
AMA StyleAleksandra Zielińska, Filipa Carreiró, Ana Oliveira, Andreia Neves, Bárbara Pires, D. Venkatesh, Alessandra Durazzo, Massimo Lucarini, Piotr Eder, Amélia Silva, Antonello Santini, Eliana Souto. Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology. Molecules. 2020; 25 (16):3731.
Chicago/Turabian StyleAleksandra Zielińska; Filipa Carreiró; Ana Oliveira; Andreia Neves; Bárbara Pires; D. Venkatesh; Alessandra Durazzo; Massimo Lucarini; Piotr Eder; Amélia Silva; Antonello Santini; Eliana Souto. 2020. "Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology." Molecules 25, no. 16: 3731.
Nowadays, there is an increasing interest in the exploitation and valorization of agricultural food waste and by-products. At the same time, the growing demand by markets worldwide, especially in Africa and Southeast Asia, can justify the growing interest in the use of by-products for the poultry industry. Olive pulp is one of the most interesting by-products of olive tree farming (typical of the Mediterranean area), being a good source of many biologically active compounds with antioxidant, antifungal, and antibacterial properties. The presence of processed olive pulp in the diet showed to be effective in increasing the weight of specific carcass and offal traits. This work aims at studying olive pulp as a feed supplement in poultry nutrition, by focusing on the effects on broiler carcass and offal. Olive pulp (OP) is one of the by-products of olive tree farming, being the residue of olive cake after it is dried. To evaluate the effects of OP in a diet supplemented with different levels of a commercial enzyme (ENZ) blend on broiler carcass and offal traits, three hundred male broiler chicks (Ross 308 lineage; one-day-old) were divided into ten treatment groups according to a completely randomized design. The treatments diets contained: unprocessed OP (50 g/kg, 100 g/kg, 50 g/kg with ENZ, 100 g/kg with ENZ), processed OP (50 g/kg, 100 g/kg, 50 g/kg with ENZ, 100 g/kg with ENZ), and control groups (without OP, and without OP with ENZ). The OP processing increased breast percentages in broilers. Supplementation with ENZ did not change any of the studied carcass or offal trait values. The presence of OP (50 g/kg) in broiler diets increased the eviscerated carcass, leg, and neck percentage values. The presence of processed OP (50 g/kg) in the diet showed to be effective in increasing the weight of specific carcass and offal traits.
Peyman Sayehban; Alireza Seidavi; Mohammad Dadashbeiki; Ahmad Ghorbani; Wagner De Araújo; Alessandra Durazzo; Massimo Lucarini; Paolo Gabrielli; Besma Omri; Luiz Teixeira Albino; Eliana Souto; Antonello Santini. Olive Pulp and Exogenous Enzymes Feed Supplementation Effect on the Carcass and Offal in Broilers: A Preliminary Study. Agriculture 2020, 10, 359 .
AMA StylePeyman Sayehban, Alireza Seidavi, Mohammad Dadashbeiki, Ahmad Ghorbani, Wagner De Araújo, Alessandra Durazzo, Massimo Lucarini, Paolo Gabrielli, Besma Omri, Luiz Teixeira Albino, Eliana Souto, Antonello Santini. Olive Pulp and Exogenous Enzymes Feed Supplementation Effect on the Carcass and Offal in Broilers: A Preliminary Study. Agriculture. 2020; 10 (8):359.
Chicago/Turabian StylePeyman Sayehban; Alireza Seidavi; Mohammad Dadashbeiki; Ahmad Ghorbani; Wagner De Araújo; Alessandra Durazzo; Massimo Lucarini; Paolo Gabrielli; Besma Omri; Luiz Teixeira Albino; Eliana Souto; Antonello Santini. 2020. "Olive Pulp and Exogenous Enzymes Feed Supplementation Effect on the Carcass and Offal in Broilers: A Preliminary Study." Agriculture 10, no. 8: 359.
Rosemary, an aromatic herb with significant antioxidative activity, is frequently used as food preservative and a source of nutraceuticals. Its antioxidant effect is mainly related to the presence of phenolic compounds, molecules considerably unstable and prone to irreversible physicochemical changes when exposed to external agents. We here proposed the loading of rosemary into structured lipid systems to improve its physicochemical properties. Four formulations were prepared using the same amount of rosemary lyophilized extract. The lipid phase was composed of stearic acid and oleic acid, and the aqueous phase, a varying combination of drying carriers (whey protein concentrate or gum Arabic) and surfactant (Poloxamer 188). The formulations were sonicated, spray-dried, and the obtained powders were characterized regarding the density (0.18 g/mL to 0.26 g/mL), particle size distribution (7 µm and 52 µm), and water solubility (29% to 48%). The antioxidant activity was determined by applying ABTS•+ radical-scavenging assay and the results expressed per gram of lyophilized extract (150.6 μmol Trolox/g to 376.4 μmol Trolox/g), with a significantly lower/higher result seen for formulations containing gum Arabic and a higher concentration of Poloxamer. The prepared systems may have potential applications as preservative in foodstuff and as nutraceutical.
Iara Baldim; Claudia Souza; Alessandra Durazzo; Massimo Lucarini; Antonello Santini; Eliana Souto; Wanderley Oliveira. Spray-Dried Structured Lipid Carriers for the Loading of Rosmarinus officinalis: New Nutraceutical and Food Preservative. Foods 2020, 9, 1110 .
AMA StyleIara Baldim, Claudia Souza, Alessandra Durazzo, Massimo Lucarini, Antonello Santini, Eliana Souto, Wanderley Oliveira. Spray-Dried Structured Lipid Carriers for the Loading of Rosmarinus officinalis: New Nutraceutical and Food Preservative. Foods. 2020; 9 (8):1110.
Chicago/Turabian StyleIara Baldim; Claudia Souza; Alessandra Durazzo; Massimo Lucarini; Antonello Santini; Eliana Souto; Wanderley Oliveira. 2020. "Spray-Dried Structured Lipid Carriers for the Loading of Rosmarinus officinalis: New Nutraceutical and Food Preservative." Foods 9, no. 8: 1110.
In this study, a conical-cylindrical spouted bed dryer with Teflon® beads as spouting material was used for producing powdered rosemary (Rosmarinus officinalis L.) extract. The influence of the inlet drying gas temperature (Tgi) and the percentage ratio between the feed rate of concentrated liquid extract by the maximum evaporation capacity of the spouted bed (Ws/Wmax) on selected physicochemical properties of the finished products were investigated. Antioxidant properties of the concentrated liquid extract and dried extracts were also evaluated by the 2.2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH) and lipid peroxidation induced by Fe2+/citrate (LPO) methods; and compared with the values obtained for a lyophilized extract (used as a control). Colloidal silicon dioxide (Tixosil® 333) and maltodextrin (DE 14) at a 2:1 ratio was added to the concentrated extract before drying (4.4% w/w) to improve the drying performance. The drying variables Ws/Wmax and Tgi have statistically significant influence on total polyphenols and total flavonoid contents of the dried powders. The concentrated extract (on dry basis—being absolute solid content) showed superior antioxidant activity (AA) compared to both the spouted bed dried and the lyophilized extracts; exhibiting IC50 values of 0.96 ± 0.02, 2.16 ± 0.04 and 3.79 ± 0.05 µg mL−1 (DPPH method) and 0.22 ± 0.01, 1.31± 0.01 and 2.54 ± 0.02 µg mL−1 (LPO method), respectively. These results of AA are comparable to values obtained for quercetin, a flavonoid compound often used as a reference standard due to its potent antioxidant activity; with IC50 of 1.17 µg mL−1 (DPPH) and 0.22 µg mL−1 (LPO). However, the dried rosemary extracts are about 13.5 times more concentrated than the initial concentrated extract (dry weight), with a concentration of total flavonoids and polyphenols compounds ranging from 4.3 to 12.3 and from 1.2 to 4.7 times higher than the concentrated extract values (wet basis). The AA per dry product mass was thus significantly higher than the values measured for concentrated extractive solution, irrespective of some losses of AA apparently due to the drying process.
Claudia R. F. Souza; Iara Baldim; Victor O. Bankole; Raquel Da Ana; Alessandra Durazzo; Massimo Lucarini; Nicola Cicero; Antonello Santini; Eliana B. Souto; Wanderley P. Oliveira. Spouted Bed Dried Rosmarinus officinalis Extract: A Novel Approach for Physicochemical Properties and Antioxidant Activity. Agriculture 2020, 10, 349 .
AMA StyleClaudia R. F. Souza, Iara Baldim, Victor O. Bankole, Raquel Da Ana, Alessandra Durazzo, Massimo Lucarini, Nicola Cicero, Antonello Santini, Eliana B. Souto, Wanderley P. Oliveira. Spouted Bed Dried Rosmarinus officinalis Extract: A Novel Approach for Physicochemical Properties and Antioxidant Activity. Agriculture. 2020; 10 (8):349.
Chicago/Turabian StyleClaudia R. F. Souza; Iara Baldim; Victor O. Bankole; Raquel Da Ana; Alessandra Durazzo; Massimo Lucarini; Nicola Cicero; Antonello Santini; Eliana B. Souto; Wanderley P. Oliveira. 2020. "Spouted Bed Dried Rosmarinus officinalis Extract: A Novel Approach for Physicochemical Properties and Antioxidant Activity." Agriculture 10, no. 8: 349.
First-generation biofuel biorefineries may be a starting point for the development of new value chains, as their by-products and side streams retain nutrients and valuable molecules that may be recovered and valorized for high-value applications. This study provides a chemical characterization of post-fermentation corn oil and thin stillage, side streams of dry-grind corn bioethanol production, in view of their valorization. An overall long-term study was conducted on the two co-products collected over 1 year from a bioethanol plant. Water content, acid value, sedimentation, mineral composition, and fatty acid profiles were analyzed on post-fermentation corn oil. Results highlighted that its acid value was high (19.72–24.29 mg KOH/g), indicating high levels of free fatty acids, but stable over the year due to standardized operating conditions. The fatty acid profile was that typical of corn oil, with a prevalence of linoleic (54–59% of total fatty acids) over oleic (23–27%) and palmitic (12–17%) acids. Macronutrients, fatty acid, and mineral profiles were investigated in thin stillage. Results revealed the acidic pH (4.05–4.68) and high dilution (90–93% water) of this side stream. The dry mass was composed of fats (19–30%), proteins (8.8–12.8%), ash (8.7–9.5%), and fiber (7.3–9.8%). The concomitant presence of a variegate complex of molecules of nutritional interest in corn bioethanol co-products, with several potential high-value market applications, make the perspective of their recovery a promising strategy to create new cross-sector interconnections according to circular economy principles.
Gabriella Di Lena; Petra Ondrejíčková; Josè Sanchez Del Pulgar; Veronika Cyprichová; Tomáš Ježovič; Massimo Lucarini; Ginevra Lombardi Boccia; Stefano Ferrari Nicoli; Paolo Gabrielli; Altero Aguzzi; Irene Casini; Roberto Caproni. Towards a Valorization of Corn Bioethanol Side Streams: Chemical Characterization of Post Fermentation Corn Oil and Thin Stillage. Molecules 2020, 25, 3549 .
AMA StyleGabriella Di Lena, Petra Ondrejíčková, Josè Sanchez Del Pulgar, Veronika Cyprichová, Tomáš Ježovič, Massimo Lucarini, Ginevra Lombardi Boccia, Stefano Ferrari Nicoli, Paolo Gabrielli, Altero Aguzzi, Irene Casini, Roberto Caproni. Towards a Valorization of Corn Bioethanol Side Streams: Chemical Characterization of Post Fermentation Corn Oil and Thin Stillage. Molecules. 2020; 25 (15):3549.
Chicago/Turabian StyleGabriella Di Lena; Petra Ondrejíčková; Josè Sanchez Del Pulgar; Veronika Cyprichová; Tomáš Ježovič; Massimo Lucarini; Ginevra Lombardi Boccia; Stefano Ferrari Nicoli; Paolo Gabrielli; Altero Aguzzi; Irene Casini; Roberto Caproni. 2020. "Towards a Valorization of Corn Bioethanol Side Streams: Chemical Characterization of Post Fermentation Corn Oil and Thin Stillage." Molecules 25, no. 15: 3549.
Brassicaceae family provides several crops which are worldwide known for their interesting phytochemical profiles, especially in terms of content of glucosinolates. These secondary metabolites show several beneficial effects toward consumers’ health, and several studies have been conducted to identify cultivation factors affecting their content in crops. One of the agronomic practices which is attracting growing interest is the organic one, which consists in avoiding the use of mineral fertilizers as well as pesticides. The aim of this study is to define the metabolic profile of Brassica oleracea (var. italica) and to compare the samples grown using organic and conventional fertilization methods. The hydroalcoholic and organic extracts of the samples have been analyzed by NMR spectroscopy. Forty-seven metabolites belonging to the categories of organic acids, amino acids, carbohydrates, fatty acids, sterols, and other molecules have been identified. Thirty-seven metabolites have been quantified. Univariate and multivariate PCA analyses allowed to observe that the organic practice influenced the nitrogen transport, the carbohydrate metabolism, the glucosinolate content and the phenylpropanoid pathway in B. oleracea (var. italica).
Massimo Lucarini; Maria Enrica Di Cocco; Valeria Raguso; Flavia Milanetti; Alessandra Durazzo; Ginevra Lombardi-Boccia; Antonello Santini; Maurizio Delfini; Fabio Sciubba. NMR-Based Metabolomic Comparison of Brassica oleracea (Var. italica): Organic and Conventional Farming. Foods 2020, 9, 945 .
AMA StyleMassimo Lucarini, Maria Enrica Di Cocco, Valeria Raguso, Flavia Milanetti, Alessandra Durazzo, Ginevra Lombardi-Boccia, Antonello Santini, Maurizio Delfini, Fabio Sciubba. NMR-Based Metabolomic Comparison of Brassica oleracea (Var. italica): Organic and Conventional Farming. Foods. 2020; 9 (7):945.
Chicago/Turabian StyleMassimo Lucarini; Maria Enrica Di Cocco; Valeria Raguso; Flavia Milanetti; Alessandra Durazzo; Ginevra Lombardi-Boccia; Antonello Santini; Maurizio Delfini; Fabio Sciubba. 2020. "NMR-Based Metabolomic Comparison of Brassica oleracea (Var. italica): Organic and Conventional Farming." Foods 9, no. 7: 945.
Medicinal plants are used worldwide due to their lower risk of side effects and eco-friendly, cost-effective production when compared to chemical drugs, encouraging researchers to further exploit the therapeutic potential of the former. One of the most popular medicinal plants is Vitex agnus-castus L., grown in tropical and sub-tropical regions, to which different health benefits have already been attributed. In this perspective article, the in vitro and in vivo therapeutic properties of V. agnus-castus L. have been analyzed and reviewed with a special focus on its health-promoting effects and potential nutraceutical applications.
Eliana B. Souto; Alessandra Durazzo; Amirhossein Nazhand; Massimo Lucarini; Massimo Zaccardelli; Selma B. Souto; Amelia M. Silva; Patricia Severino; Ettore Novellino; Antonello Santini. Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives. Forests 2020, 11, 761 .
AMA StyleEliana B. Souto, Alessandra Durazzo, Amirhossein Nazhand, Massimo Lucarini, Massimo Zaccardelli, Selma B. Souto, Amelia M. Silva, Patricia Severino, Ettore Novellino, Antonello Santini. Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives. Forests. 2020; 11 (7):761.
Chicago/Turabian StyleEliana B. Souto; Alessandra Durazzo; Amirhossein Nazhand; Massimo Lucarini; Massimo Zaccardelli; Selma B. Souto; Amelia M. Silva; Patricia Severino; Ettore Novellino; Antonello Santini. 2020. "Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives." Forests 11, no. 7: 761.