A brain tumor is an abnormal growth in brain cells that causes damage to various blood vessels and nerves in the human body. An earlier and accurate diagnosis of the brain tumor is of foremost important to avoid future complications. Precise segmentation of brain tumors provides a basis for surgical planning and treatment to doctors. Manual detection using MRI images is computationally complex in cases where the survival of the patient is dependent on timely treatment, and the performance relies on domain expertise. Therefore, computerized detection of tumors is still a challenging task due to significant variations in their location and structure, i.e., irregular shapes and ambiguous boundaries. In this study, we propose a custom Mask Region-based Convolution neural network (Mask RCNN) with a densenet-41 backbone architecture that is trained via transfer learning for precise classification and segmentation of brain tumors. Our method is evaluated on two different benchmark datasets using various quantitative measures. Comparative results show that the custom Mask-RCNN can more precisely detect tumor locations using bounding boxes and return segmentation masks to provide exact tumor regions. Our proposed model achieved an accuracy of 96.3% and 98.34% for segmentation and classification respectively, demonstrating enhanced robustness compared to state-of-the-art approaches.

Tomato plants' disease detection and classification at the earliest stage can save the farmers from expensive crop sprays and can assist in increasing the food quantity. Although, extensive work has been presented by the researcher for the tomato plant disease classification, however, the timely localization and identification of various tomato leaf diseases is a complex job as a consequence of the huge similarity among the healthy and affected portion of plant leaves. Furthermore, the low contrast information between the background and foreground of the suspected sample has further complicated the plant leaf disease detection process. To deal with the aforementioned challenges, we have presented a robust deep learning (DL)-based approach namely ResNet-34-based Faster-RCNN for tomato plant leaf disease classification. The proposed method includes three basic steps. Firstly, we generate the annotations of the suspected images to specify the region of interest (RoI). In the next step, we have introduced ResNet-34 along with Convolutional Block Attention Module (CBAM) as a feature extractor module of Faster-RCNN to extract the deep key points. Finally, the calculated features are utilized for the Faster-RCNN model training to locate and categorize the numerous tomato plant leaf anomalies. We tested the presented work on an accessible standard database, the PlantVillage Kaggle dataset. More specifically, we have obtained the mAP and accuracy values of 0.981, and 99.97% respectively along with the test time of 0.23 s. Both qualitative and quantitative results confirm that the presented solution is robust to the detection of plant leaf disease and can replace the manual systems. Moreover, the proposed method shows a low-cost solution to tomato leaf disease classification which is robust to several image transformations like the variations in the size, color, and orientation of the leaf diseased portion. Furthermore, the framework can locate the affected plant leaves under the occurrence of blurring, noise, chrominance, and brightness variations. We have confirmed through the reported results that our approach is robust to several tomato leaf diseases classification under the varying image capturing conditions. In the future, we plan to extend our approach to apply it to other parts of plants as well.

Diabetic retinopathy (DR) is an eye disease that alters the blood vessels of a person suffering from diabetes. Diabetic macular edema (DME) occurs when DR affects the macula, which causes fluid accumulation in the macula. Efficient screening systems require experts to manually analyze images to recognize diseases. However, due to the challenging nature of the screening method and lack of trained human resources, devising effective screening-oriented treatment is an expensive task. Automated systems are trying to cope with these challenges; however, these methods do not generalize well to multiple diseases and real-world scenarios. To solve the aforementioned issues, we propose a new method comprising two main steps. The first involves dataset preparation and feature extraction and the other relates to improving a custom deep learning based CenterNet model trained for eye disease classification. Initially, we generate annotations for suspected samples to locate the precise region of interest, while the other part of the proposed solution trains the Center Net model over annotated images. Specifically, we use DenseNet-100 as a feature extraction method on which the one-stage detector, CenterNet, is employed to localize and classify the disease lesions. We evaluated our method over challenging datasets, namely, APTOS-2019 and IDRiD, and attained average accuracy of 97.93% and 98.10%, respectively. We also performed cross-dataset validation with benchmark EYEPACS and Diaretdb1 datasets. Both qualitative and quantitative results demonstrate that our proposed approach outperforms state-of-the-art methods due to more effective localization power of CenterNet, as it can easily recognize small lesions and deal with over-fitted training data. Our proposed framework is proficient in correctly locating and classifying disease lesions. In comparison to existing DR and DME classification approaches, our method can extract representative key points from low-intensity and noisy images and accurately classify them. Hence our approach can play an important role in automated detection and recognition of DR and DME lesions.

Breast cancer (BC) is the second most prevalent type of cancer among women leading to death, and its rate of mortality is very high. Its effects will be reduced if diagnosed early. BC’s early detection will greatly boost the prognosis and likelihood of recovery, as it may encourage prompt surgical care for patients. It is therefore vital to have a system enabling the healthcare industry to detect breast cancer quickly and accurately. Machine learning (ML) is widely used in breast cancer (BC) pattern classification due to its advantages in modelling a critical feature detection from complex BC datasets. In this paper, we propose a system for automatic detection of BC diagnosis and prognosis using ensemble of classifiers. First, we review various machine learning (ML) algorithms and ensemble of different ML algorithms. We present an overview of ML algorithms including ANN, and ensemble of different classifiers for automatic BC diagnosis and prognosis detection. We also present and compare various ensemble models and other variants of tested ML based models with and without up-sampling technique on two benchmark datasets. We also studied the effects of using balanced class weight on prognosis dataset and compared its performance with others. The results showed that the ensemble method outperformed other state-of-the-art methods and achieved 98.83% accuracy. Because of high performance, the proposed system is of great importance to the medical industry and relevant research community. The comparison shows that the proposed method outperformed other state-of-the-art methods.

Text data plays an imperative role in the biomedical domain. As patient’s data comprises of a huge amount of text documents in a non-standardized format. In order to obtain the relevant data, the text documents pose a lot of challenging issues for data processing. Topic modeling is one of the popular techniques for information retrieval based on themes from the biomedical documents. In topic modeling discovering the precise topics from the biomedical documents is a challenging task. Furthermore, in biomedical text documents, the redundancy puts a negative impact on the quality of text mining as well. Therefore, the rapid growth of unstructured documents entails machine learning techniques for topic modeling capable of discovering precise topics. In this paper, we proposed a topic modeling technique for text mining through hybrid inverse document frequency and machine learning fuzzy k-means clustering algorithm. The proposed technique ameliorates the redundancy issue and discovers precise topics from the biomedical text documents. The proposed technique generates local and global term frequencies through the bag-of-words (BOW) model. The global term weighting is calculated through the proposed hybrid inverse documents frequency and Local term weighting is computed with term frequency. The robust principal component analysis is used to remove the negative impact of higher dimensionality on the global term weights. Afterward, the classification and clustering for text mining are performed with a probability of topics in the documents. The classification is performed through discriminant analysis classifier whereas the clustering is done through the k-means clustering. The performance of clustering is evaluated with Calinsiki-Har-abasz (CH) index internal validation method. The proposed toping modeling technique is evaluated on six standard datasets namely Ohsumed, MuchMore Springer Corpus, GENIA corpus, Bioxtext, tweets and WSJ redundant corpus for experimentation. The proposed topic modeling technique exhibits high performance on classification and clustering in text mining compared to baseline topic models like FLSA, LDA, and LSA. Moreover, the execution time of the proposed topic modeling technique remains stable for different numbers of topics.