The largest human organ, the skin, serves a variety of essential functions including protection, preservation of water and electrolytes, regulation of body temperature, and fat storage. Its maintenance and preservation are supported by cosmetic products, whose functions include cleaning, protection, and modulation. The market for these products is predicted to increase from 100.13 billion USD in 2021 to 145.82 billion USD in 2028. Recently, it has been suggested that grape by-products (totalling 14.5 million tons per year just in Europe) has a great potential to be used in the creation of new cosmetic products. In this regard, this article aims to provide a comprehensive overview of the current state of knowledge regarding the bioactive compounds in grape pomace, the advantages of applying them to the skin, and the main cosmetic products already on the market incorporating these bioactives. Most of these compounds are derived from the Vitis vinifera L. species, and exhibit several biological properties, such as antioxidant, antimicrobial, anti-inflammatory, inhibition of skin degrading enzymes, protection from UVA damage, increased cell viability, and skin whitening effect. On the other hand, nanoencapsulation techniques can provide a significant improvement in the stability of grape-derived bioactive compounds, in particular of resveratrol, and this issue is also addressed in a critical manner in this review.

Phospholipase A2 (EC 3.1.1.4) hydrolyzes certain phospholipids of low density lipoprotein (LDL). Plasma clearance of phospholipase A2-modified human LDL is up to 17 times faster than that of native human LDL in hypercholesterolemic rabbits. Modification of blood lipoproteins of hypercholesterolemic rabbits was performed by using an extracorporeal circuit containing immobilized phospholipase A2. After 90-min treatments, nearly 30% decreases in plasma cholesterol concentrations were observed. Erythrocyte, leukocyte, and platelet counts showed no net change after treatment. This technique does not require any fluid replacement or sorbent regeneration and offers a potential approach for lowering serum cholesterol and LDL levels.

The skin is the largest organ in the human body and serves multiple functions such as barrier protection and thermoregulation. The maintenance of its integrity and healthy structure is of paramount importance. Accordingly, technological advances in cosmetic sciences have been directed towards optimizing these factors. Plant-derived ingredients have been explored for their bioactivity profiles and sustainable sources. Grape by-products contain a group of bioactive molecules that display important biological activities. Nonetheless, many of these molecules (e.g., phenolic compounds) are unstable and susceptible to degradation. So, their encapsulation using nano/microsystems (i.e., microdispersions) has been explored as a promising solution. In this work, two grape seed extracts were obtained, one from a single grape variety (GSE-Ov) and another from a mix of five grape varieties (GSE-Sv). These extracts were analysed for their antioxidant and antimicrobial activities, as well as their chemical composition and molecular structure. The extract that showed the most promising properties was GSE-Ov with a DPPH IC₅₀ of 0.079 mg mL⁻¹. This extract was encapsulated in soy lecithin microdispersions coated with pectin, with an encapsulation efficiency of 88.8%. They showed an in vitro release of polyphenols of 59.4% during 24 h. The particles displayed a zeta potential of −20.3 mV and an average diameter of 13.6 µm. Microdispersions proved to be safe under 5 and 2.5 mg mL⁻¹ in HaCaT and HDF cell models, respectively. Additionally, they demonstrated anti-inflammatory activity against IL-1α when tested at 2 mg mL⁻¹. This work enabled the valorisation of a by-product from the wine industry by using natural extracts in skincare products.