In-vehicle air quality monitoring systems have been seen as promising paradigms for monitoring drivers’ conditions while they are driving. This is because some in-vehicle cabins contain pollutants that can cause drowsiness and fatigue to drivers. However, designing an efficient system that can predict in-vehicle air quality has challenges, due to the continuous variation in parameters in cabin environments. This paper presents a new approach, using deep learning techniques that can deal with the varying parameters inside the vehicle environment. In this case, two deep learning models, namely Long-short Term Memory (LSTM) and Gated Recurrent Unit (GRU) are applied to classify and predict the air quality using time-series data collected from the built-in sensor hardware. Both are compared with conventional methods of machine learning models, including Support Vector Regression (SVR) and Multi-layer Perceptron (MLP). The results show that GRU has an excellent prediction performance with the highest coefficient of determination value (R²) of 0.97.