Leopold Simma

Dr. Leopold Simma

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Research Focus & Metrics

Academic Career Length

10Years (2017-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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30 October 2020 in Emergency Medicine Journal
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LSLeopold Simma
Leopold Simma
FBFlorian Bauder
Florian Bauder
TSThomas Schmitt-Mechelke
Thomas Schmitt-Mechelke
Introduction The aim of this study was to determine the feasibility and clinical utility of point-of-care electroencephalogram (pocEEG) in the paediatric emergency department (ED) for children presenting with acute non-traumatic central nervous system (CNS) disorders. Methods Retrospective observational study of prospectively collected data in paediatric patients (0–16 years) with acute non-traumatic CNS-disorders presenting between April 2014 and February 2017 to a single paediatric ED in Switzerland. The 2-channel EEG was applied to all patients presenting with acute seizures or impaired consciousness to the ED. For a pocEEG, scalp surface electrodes are applied in five locations, thus allowing registration of fronto-temporal bilateral cortical activity. Neurology consultants assisted with interpretation of readings. EEG findings and clinical characteristics were collected. Feasibility and usefulness were rated via Likert scale. Results 36 patients with acute seizures or altered mental status were analysed. Age range was 9 months to 15 years, median age of 34 months. 21 of 36 (58%) patients arrived out of hours. Application of electrodes was rated as ‘easy’ in 28 (77.8%) patients and rated as ‘difficult’ in 8 (22.2%). The utility of the EEG was rated by physicians as ‘very useful/diagnostic’ in 13 cases (36%), ‘useful’ in 21 cases (58%), ‘not useful’ in two cases (8%). None were rated ‘negative.’ Conclusion Uptake of pocEEG introduction has been very encouraging. Provider ratings were overwhelmingly positive. Recognition of non-convulsive status epilepticus was improved and pocEEG facilitated more targeted interventions.

11 October 2021 in Frontiers in Pediatrics
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Journal Article
Open access
LSLeopold Simma
Leopold Simma
MSMartin Stocker
Martin Stocker
MLMarkus Lehner
Markus Lehner
LWLea Wehrli
Lea Wehrli
FRFranziska Righini-Grunder
Franziska Righini-Grunder
Objective:Delivery of prompt and adequate care for critically ill and injured children presenting to the pediatric emergency department (PED) is paramount for optimal outcomes. Knowledge of the local epidemiology, patient profile, and presentation modes are key for organizational planning, staff education strategy, and optimal care in a PED. Our aim was to analyze the profile of critically ill and injured children admitted to a tertiary, non-academic Swiss PED, to investigate potential risk factors associated with admission to the pediatric intensive care unit (PICU), and the outcomes mortality and PICU admission.Methods:Prospective cohort study of critically ill and injured children presenting to the PED over a two-year period (2018–2019). Inclusion criteria were Australasian triage scale category (ATS) 1, trauma team activation (TTA), medical emergency response (MER) activation, additional critical care consult, and transfer to an outside hospital.Results:Of 42,579 visits during the two-year period, 347 presentations matched the inclusion criteria (0.81%). Leading presentations were central nervous system (CNS) disorders (26.2%), trauma (25.1%), and respiratory emergencies (24.2%). 288 out of 347 cases (83%) arrived during the day or evening with an even distribution over the days of the week. 128 out of 347 (37%) arrived unexpectedly as walk-ins. 233 (67.15%) were ATS category 1. 51% of the cohort was admitted to PICU. Australasian triage scale category 1 was significantly more common in this group (p= 0.0001). Infants with respiratory disease had an increased risk of PICU transfer compared to other age groups (OR 4.18 [95%CI 2.46, 7.09]p= 0.0001), and this age group presented mainly as walk-in (p= 0.0001). Pediatric intensive care unit admissions had a longer hospital stay (4 [2, 8] days vs. 2 [1, 4] days,p= 0.0001) compared to other patients. 0.045% of all PED patients had to be transferred out. Three deaths (0.86%) occurred in the PED, 10 patients died in the PICU (2.9%).Conclusions:High acuity presentations in the PED were rare, more likely to be young with CNS disorders, trauma and respiratory diseases. A significant proportion were unexpected walk-in presentations, mainly during day and evening shifts. Low exposure to high-acuity patients highlights the importance of deliberate learning and simulation for all professionals in the PED.

7 March 2025 in European Journal of Pediatrics
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Journal Article
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LSLeopold Simma
Leopold Simma
AKAnna Kammerl
Anna Kammerl
GRGeorgia Ramantani
Georgia Ramantani
Central nervous system (CNS) disorders, including seizures, status epilepticus (SE), and altered mental status, constitute a significant proportion of cases presenting in the pediatric emergency department. EEG is essential for diagnosing nonconvulsive SE, but standard EEG is often unavailable due to resource constraints. Point-of-care EEG (pocEEG) has emerged as a viable alternative, offering rapid bedside assessment. This systematic review synthesizes existing data on the use of pocEEG in pediatric emergencies and highlights research gaps. A comprehensive search of PubMed, CINAHL, and EMBASE identified six studies on pediatric populations using simplified EEG montages, with cohort sizes ranging from 20 to 242 patients. The findings indicate that pocEEG is feasible in acute pediatric care, effectively aiding in the detection of nonconvulsive SE and other critical neurological conditions. The studies varied in electrode placement strategies, ranging from neonatal to subhairline montages. Conclusion: Despite some implementation challenges, pocEEG has shown sufficient accuracy for clinical use. Further research should focus on optimizing EEG montages, refining interpretation, and assessing its impact on patient outcomes. This review underscores the potential of pocEEG to address critical care needs in pediatric emergency departments and calls for larger, standardized studies. What is Known:• Central nervous system (CNS) disorders, such as seizures and altered mental status, are common and critical conditions encountered in pediatric emergency resuscitation bays.• EEG is essential for diagnosing nonconvulsive status epilepticus, but standard EEG is often unavailable in emergency departments due to logistical challenges, limited resources, and the need for specialized interpretation. What is New:• Reduced-lead, point-of-care EEG (pocEEG) is a feasible alternative for real-time bedside CNS monitoring in pediatric emergency settings, aiding in the diagnosis of nonconvulsive status epilepticus and guiding the management of convulsive status epilepticus.• This systematic review highlights the feasibility and clinical potential of pocEEG in pediatric emergency departments and identifies key areas for further research, including the development of standardized pocEEG protocols and the integration of automated EEG analysis.

30 March 2022 in Journal of Radiological Protection
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Journal Article
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LSLeopold Simma
Leopold Simma
JFJuergen Fornaro
Juergen Fornaro
NSNikolai Stahr
Nikolai Stahr
MLMarkus Lehner
Markus Lehner
JRJustus E Roos
Justus E Roos
TLThiago Viana Miranda Lima
Thiago Viana Miranda Lima
We aimed to evaluate the impact of a low-dose whole-body computed tomography (WBCT) protocol on radiation doses in paediatric major trauma patients. Retrospective cohort study of paediatric trauma patients (<16 years) at a national level 1 paediatric trauma centre (PTC) over a 6 year period prior and post introduction of a low-dose WBCT protocol (2014–2019). Demographic data, patient characteristics, CT device, and exposure information including scan range, dose-length product, and volume CT dose index were collected. Effective dose (ED) and exposure parameters were compared before and after protocol introduction. Forty-eight patients underwent WBCT during the study period. Prior to introduction of the low-dose protocol (n = 18), the ED was 20.6 mSv (median 20.1 ± 5.3 mSv [range 12.5–30.7]). After introduction of the low-dose WBCT protocol (n = 30), mean ED was 4.8 mSv (median 2.6 ± 5.0 [range: 0.8–19.1]). This resulted in a reduction of 77% in mean ED (p value <0.001). Significant radiation dose reduction of 77% can be achieved with low-dose WBCT protocols in PTCs.

11 August 2023 in Children
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Journal Article
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AHAnouk Herren
Anouk Herren
CPCameron Palmer
Cameron Palmer
MLMarkus A. Landolt
Markus A. Landolt
MLMarkus Lehner
Markus Lehner
TNThomas J. Neuhaus
Thomas J. Neuhaus
LSLeopold Simma
Leopold Simma
Background. Trauma is one of the most common causes of death in childhood, but data on severely injured Swiss children are absent from existing national registries. Our aim was to analyze trauma activations and the profiles of critically injured children at a tertiary, non-academic Swiss pediatric emergency department (PED). In the absence of a national pediatric trauma database, this information may help to guide the design of infrastructure, processes within organizations, training, and policies. Methods. A retrospective analysis of pediatric trauma patients in a prospective resuscitation database over a 2-year period. Critically injured trauma patients under the age of 16 years were included. Patients were described with established triage and injury severity scales. Statistical evaluation included logistic regression analysis. Results. A total of 82 patients matched one or more of the study inclusion criteria. The most frequent age group was 12–15 years, and 27% were female. Trauma team activation (TTA) occurred with 49 patients (59.8%). Falls were the most frequent mechanism of injury, both overall and for major trauma. Road-traffic-related injuries had the highest relative risk of major trauma. In the multivariate analysis, patients receiving medicalized transport were more likely to trigger a TTA, but there was no association between TTA and age, gender, or Injury Severity Score (ISS). Nineteen patients (23.2%) sustained major trauma with an ISS > 15. Injuries of Abbreviated Injury Scale severity 3 or greater were most frequent to the head, followed by abdomen, chest, and extremities. The overall mortality rate in the cohort was 2.4%. Conclusions: Major trauma presentations only comprise a small proportion of the total patient load in the PED, and trauma team activation does not correlate with injury severity. Low exposure to high-acuity patients highlights the importance of deliberate learning and simulation for all professionals in the PED. Our findings indicate that high priority should be given to training in the management of severely injured children in the PED. The leading major trauma mechanisms were preventable, which should prompt further efforts in injury prevention.

20 September 2023 in Journal of Personalized Medicine
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Journal Article
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LSLeopold Simma
Leopold Simma
FRFabrizio Romano
Fabrizio Romano
SSSteffen Schmidt
Steffen Schmidt
GRGeorgia Ramantani
Georgia Ramantani
BHBigna Katrin Bölsterli Heinzle
Bigna Katrin Bölsterli Heinzle
Central nervous system (CNS) disorders are among the most frequent presentations in critically ill children. Status epilepticus (SE) is a frequent scenario in the resuscitation bay. In patients with altered mental status, non-convulsive SE (NCSE) is often underrecognized and critically impacts the neurological outcome and duration of hospitalization. An electroencephalogram (EEG) is required to diagnose NCSE. However, standard EEG recordings are time- and staff-intensive, and their availability is limited, especially outside regular working hours. We aimed to improve patient care by developing a simplified EEG recording method, using a reduced lead montage (point-of-care EEG—pocEEG), that is suitable for use in pediatric emergency departments. The objective was to devise a cost-effective unit with low space requirements that fitted the existing technical infrastructure. We present two technical options for clinical pocEEG acquisition using patient monitors (GE Carescape, Philips IntelliVue) that enable data collection for educational and research purposes. A simplified, rapid response EEG like the pocEEG enables neuromonitoring of patients with CNS disorders in pediatric emergency settings, facilitating timely diagnosis and treatment initiation when standard EEG is not readily available.