There is a growing focus on person-centered care, emphasizing the importance of respecting inter-individual differences and implementing individualized treatment initiatives. Prior research has established an association between personality traits, body mass index, and health-related behaviors. The aim of this study was to explore the potential of personality trait assessments in identifying individuals at risk of glycemic dysregulation and increasing BMI. This cross-sectional study used a dataset comprising 140 participants with diabetes who completed the Big Five personality trait questionnaire from the Lolland-Falster Health Study. Logistic regression was used to investigate associations between personality traits, glycemic control, and BMI ≥ 25. No significant associations between personality traits and glycemic control were found. There was a significant association between agreeableness and lower odds of BMI ≥ 25 in the unadjusted analysis (OR 0.54 (0.34–0.86)), which persisted after adjusting for sex, age, and education (OR 0.54 (0.33–0.89)). No significant association between glycemic control and personality traits was observed in this small sample study. However, higher levels of agreeableness were associated with a lower likelihood of having a BMI of ≥25. This preliminary study suggests that integrating personality assessments could help identify individuals at risk of increasing BMI. These findings highlight the potential of using personality traits to guide targeted interventions, offering a direction for future research.

This review provides an overview of the evidence regarding mtDNA and valid biomarkers for assessing mitochondrial adaptions. Mitochondria are small organelles that exist in almost all cells throughout the human body. As the only organelle, mitochondria contain their own DNA, mitochondrial DNA (mtDNA). mtDNA-encoded polypeptides are subunits of the enzyme complexes in the electron transport chain (ETC) that are responsible for production of ATP to the cells. mtDNA is frequently used as a biomarker for mitochondrial content, since changes in mitochondrial volume are thought to induce similar changes in mtDNA. However, some exercise studies have challenged this “gene-dosage theory”, and have indicated that changes in mitochondrial content can adapt without changes in mtDNA. Thus, the aim of this scoping review was to summarize the studies that used mtDNA as a biomarker for mitochondrial adaptions and address the question as to whether changes in mitochondrial content, induce changes in mtDNA in response to aerobic exercise in the healthy skeletal muscle. The literature was searched in PubMed and Embase. Eligibility criteria included: interventional study design, aerobic exercise, mtDNA measurements reported pre- and postintervention for the healthy skeletal muscle and English language. Overall, 1585 studies were identified. Nine studies were included for analysis. Eight out of the nine studies showed proof of increased oxidative capacity, six found improvements in mitochondrial volume, content and/or improved mitochondrial enzyme activity and seven studies did not find evidence of change in mtDNA copy number. In conclusion, the findings imply that mitochondrial adaptions, as a response to aerobic exercise, can occur without a change in mtDNA copy number.

The care needs of children and adolescents with type 1 diabetes and their families are frequently approached as if they were identical to those of adults, overlooking the distinct challenges young people may face. It has been stated that children and adolescents often find conventional conversations with diabetes specialists tiresome and unpleasant. The present study focuses on familial experiences of an advanced carbohydrate counting program tailored to children and adolescents. The data encompass semi-structured interviews with families who participated in a group-based child-centered advanced carbohydrate counting program. The analysis revealed five themes: (1) peer-to-peer interaction is an essential determinant of sharing and learning; (2) illness perception significantly influences dietary intake; (3) normalization of diabetes in everyday life eases the disease burden; (4) repetition of dietary knowledge is important for retention; and (5) creating a safe and playful learning environment is crucial to engaging children and adolescents in their own treatment. The present findings suggest that it would be beneficial to explore and consider alternative teaching approaches that are adapted to a more interactive and engaging learning environment that is specifically tailored to children and adolescents. This entails moving away from traditional individual approaches.

Background: Existing research in personality traits provides evidence of associations between Conscientiousness, Neuroticism and Body Mass Index (BMI), with a growing interest in the concept of Healthy Neuroticism. However, the associations are not fully understood, and the mitigating role of health behaviours remains insufficiently investigated.Methods: This cross-sectional study investigated associations between Neuroticism, Conscientiousness, including high and low scores, Healthy and Unhealthy Neuroticism with BMI, and the mediating effects of physical activity and caring about having a healthy and nutritious diet, in a national sample of 21,619 adults. Personality traits were assessed using the Big Five Inventory-10, and health behaviours via self-reported physical activity and attitudes towards a healthy and nutritious diet. Statistical analyses were conducted using Hayes PROCESS macro for mediation with 5,000 bootstrap samples.Results: The results demonstrated that Neuroticism and Unhealthy Neuroticism were positively associated with BMI, whereas Conscientiousness and Healthy Neuroticism showed negative associations. Health behaviours both fully and partially mediated the relationship between personality traits and BMI.Conclusion: These findings provide evidence for Healthy and Unhealthy Neuroticism in relation to BMI and health behaviours. Furthermore, findings demonstrate associations between Neuroticism, Conscientiousness and BMI, with physical activity, and diet awareness acting as mediators. Stratified analysis suggests that the role of educational level in these relationships likely reflects underlying differences in health behaviours.

Background/Objectives: Effective glycemic management from the time of diagnosis is essential in the care of children and adolescents with type 1 diabetes (T1D), as early glycemic patterns can influence long-term health outcomes. Methods: This exploratory study evaluated a one-month interactive, group- and play-based education program designed to enhance food and carbohydrate counting skills among families of children and adolescents with newly diagnosed (ND) T1D ( 7.5% (58 mmol/mol)). The intervention included hands-on learning activities in food and carbohydrate counting, and peer interaction to support development of diabetes self-management skills. Data were collected at baseline, post-intervention, and at six-months follow-up through medical records, glucose sensor data, and a questionnaire assessing diabetes self-management skills, dietary practices, and carbohydrate counting. Results: Between September 2022 and April 2024, 55 children and adolescents were enrolled in the ND group and 22 in the SGC group. Post-intervention, carbohydrate counting skills improved, particularly in the ND group. Participants reported greater confidence and independence in carbohydrate counting and insulin dosing, with parents noting sustained benefits at six-months follow-up. No significant changes were observed in glycemic control, including time-in-range and postprandial glucose profiles. Conclusions: In this exploratory study, early interactive and play-based group education was associated with improvements in carbohydrate counting skills and self-care confidence in children and adolescents with newly diagnosed T1D. These improvements were not accompanied by changes in glycemic outcomes. The findings occurred during a complex and transitional phase following diagnosis. Further research is needed to examine sustainability and long-term clinical impact.

Contemporary diabetes care is largely organised around one-to-one clinical consultations and the regulation of biomedical outcomes. While such approaches remain essential, they may be insufficient for addressing the social and behavioural aspects of chronic disease management. Based on this conceptual perspective, we propose the Friendly Neighbourhood Hospital as an approach to supporting peer contact and self-management, complementing clinical care. Drawing on affordance theory, social architecture, and urban social geography, we argue that hospital environments can shape participation, learning, and behavioural change through mechanisms including peer interaction, tacit knowledge, situated learning, and institutional trust. We illustrate this approach using five settings: communal cooking, movement and social interaction, public and cultural events, flexible access, and digital participation. These examples are illustrative and not evaluated interventions, and their anticipated effects, ranging from immediate participation and belonging to longer-term behavioural change, remain hypotheses for future testing. From this perspective, we do not advocate for replacing individual consultations but rather for repositioning them within a broader social and spatial context.