Magnetic nanocomposites based on Betazeolites and magnetite nanoparticles modified with polydiallyldimethylammonium chloride are synthesized under hydrothermal conditions. Particles of an...

A comparative study of the properties of aluminosilicates of the kaolinite (Al₂Si₂O₅(OH)₄∙nH₂O) group with different particles morphology has been carried out. Under conditions of directed hydrothermal synthesis, kaolinite nanoparticles with spherical, sponge, and platy morphologies were obtained. Raw nanotubular halloysite was used as particles with tubular morphology. The samples were studied by X-ray diffraction, SEM, solid-state NMR, low-temperature nitrogen adsorption, and the dependence of the zeta potential of the samples on the pH of the medium was defined. The sorption capacity with respect to cationic dye methylene blue in aqueous solutions was studied. It was found that sorption capacity depends on particles morphology and decreases in the series spheres-sponges-tubes-plates. The Langmuir, Freundlich, and Temkin models describe experimental methylene blue adsorption isotherms on aluminosilicates of the kaolinite subgroup with different particles morphology. To process the kinetic data, pseudo-first order and pseudo-second order were used. For the first time, studies of the dependence of hemolytic activity and cytotoxicity of aluminosilicate nanoparticles on their morphology were carried out. It was found that aluminosilicate nanosponges and spherical particles are not toxic to human erythrocytes and do not cause their destruction at sample concentrations from 0.1 to 1 mg/g. Based on the results of the MTT test, the concentration value that causes 50% inhibition of cell population growth (IC₅₀, mg/mL) was calculated. For nanotubes, this value turned out to be the smallest—0.33 mg/mL. For samples with platy, spherical and nanosponge morphology, the IC₅₀ values were 1.55, 2.68, and 4.69 mg/mL, respectively.

The factors influencing the appearance of toxicity in samples of synthetic montmorillonite with a systematically changing chemical composition Na_x(Al, Mg)_2-3Si₄O₁₀(OH)₂ nH₂O, which are potentially important for their use in medicine as drug carriers, targeted drug delivery systems, entero- and hemosorbents have been studied. Samples synthesized under hydrothermal conditions had the morphology of nanolayers self-organized into the nanosponge structures. The effect of the aluminum content, particle sizes, porosity, and ζ-potential of the samples on their toxicity was studied. The cytotoxic effect of the samples on eukaryotic cells Ea. hy 926 was determined using the MTT assay. The hemolytic activity of the samples in the wide concentration range in relation to human erythrocytes was also estimated. It has been established that the toxicity of aluminosilicate nanoparticles can be significantly reduced by correctly selecting their synthesis conditions and chemical composition, which opens up the opportunities for their use in medicine.

Nanocomposites based on zeolite Betaand magnetite nanoparticles (MNs) are obtained under hydrothermal conditions. Nanoparticles synthesized under various conditions and having different surface...