Apoptosis is a programmed cell death comprising two signaling cascades including the intrinsic and extrinsic pathways. This process has been shown to be involved in the therapy response of different cancer types, making it an effective target for treating cancer. Cancer has been considered a challenging issue in global health. Cancer cells possess six biological characteristics during their developmental process known as cancer hallmarks. Hallmarks of cancer include continuous growth signals, unlimited proliferation, resistance to proliferation inhibitors, apoptosis escaping, active angiogenesis, and metastasis. Sesquiterpene lactones are one of the large and diverse groups of planet-derived phytochemicals that can be used as sources for a variety of drugs. Some sesquiterpene lactones possess many biological activities such as anti-inflammatory, anti-viral, anti-microbial, anti-malarial, anticancer, anti-diabetic, and analgesic. This review article briefly overviews the intrinsic and extrinsic pathways of apoptosis and the interactions between the modulators of both pathways. Also, the present review summarizes the potential effects of sesquiterpene lactones on different modulators of the intrinsic and extrinsic pathways of apoptosis in a variety of cancer cell lines and animal models. The main purpose of the present review is to give a clear picture of the current knowledge about the pro-apoptotic effects of sesquiterpene lactones on various cancers to provide future direction in cancer therapeutics.

Quality has become one of the most crucial criteria in an institution’s success and survival as there is nothing more than what an era of globalization and intensity demands. Successful businesses recognize that consumer reliability may have a severe influence on their bottom lines. As a result, several competitive companies are constantly raising their quality requirements. Competitive companies think that improving quality is the best way to recover, and most authors have specified various procedures relevant to their processes. The majority of automobile assembly sectors are looking for high-quality requirements in their manufacturing techniques and are executing a quality system known as total productive maintenance (TPM). The study’s goal is to deploy the TPM program inside the metal forming industry to improve metal industry workstations. The overall equipment effectiveness (OEE) for various workstations such as rolling, bending, cutting, and die punching for the fiscal year 2018–2019 has been evaluated. In addition to the other reasons, inefficient resource utilization is a significant component that diminishes the factory’s OEE. In the financial year 2019–2020, the TPM approach was adopted in the enterprise. As a result, there has been an improvement in overall performance.