This page has only limited features, please log in for full access.
More than five decades have been invested in understanding glucose biosensors. Yet, this immensely versatile field has continued to gain attention from the scientific world to better understand and diagnose diabetes. However, such extensive work done to improve glucose sensing devices has still not yielded desirable results. Drawbacks like the necessity of the invasive finger pricking step and the lack of optimization of diagnostic interventions still need to be considered to improve the testing process of diabetic patients. To upgrade the glucose-sensing devices and reduce the number of intermediary steps during glucose measurement, fourth-generation glucose sensors (FGGS) have been introduced. These sensors, made using robust electrocatalytic copper nanostructures, improve diagnostic efficiency and cost-effectiveness. This review aims to present the essential scientific progress in copper nanostructure-based FGGS in the past ten years (2010 – present). After a short introduction, we presented the working principles of these sensors. We then highlighted the importance of copper nanostructures as advanced electrode materials to develop reliable real-time FGGS. Finally, we cover the advantages, shortcomings, and prospects for developing highly sensitive, stable, and specific FGGS.
Tasbiha Awan; Gowhar A. Naikoo; Hiba Salim; Fareeha Arshad; Israr U. Hassan; Mona Zamani Pedram; Waqar Ahmed; Hakkim L. Faruck; Alaa A. A. Aljabali; Vijay Mishra; Ángel Serrano‐Aroca; Rohit Goyal; Poonam Negi; Martin Birkett; Mohamed M. Nasef; Nitin B. Charbe; Hamid A. Bakshi; Murtaza M. Tambuwala. Fourth Generation Glucose Sensors Composed of Copper Nanostructures for Diabetes Management: A Critical Review. Bioengineering & Translational Medicine 2021, e10248 .
AMA StyleTasbiha Awan, Gowhar A. Naikoo, Hiba Salim, Fareeha Arshad, Israr U. Hassan, Mona Zamani Pedram, Waqar Ahmed, Hakkim L. Faruck, Alaa A. A. Aljabali, Vijay Mishra, Ángel Serrano‐Aroca, Rohit Goyal, Poonam Negi, Martin Birkett, Mohamed M. Nasef, Nitin B. Charbe, Hamid A. Bakshi, Murtaza M. Tambuwala. Fourth Generation Glucose Sensors Composed of Copper Nanostructures for Diabetes Management: A Critical Review. Bioengineering & Translational Medicine. 2021; ():e10248.
Chicago/Turabian StyleTasbiha Awan; Gowhar A. Naikoo; Hiba Salim; Fareeha Arshad; Israr U. Hassan; Mona Zamani Pedram; Waqar Ahmed; Hakkim L. Faruck; Alaa A. A. Aljabali; Vijay Mishra; Ángel Serrano‐Aroca; Rohit Goyal; Poonam Negi; Martin Birkett; Mohamed M. Nasef; Nitin B. Charbe; Hamid A. Bakshi; Murtaza M. Tambuwala. 2021. "Fourth Generation Glucose Sensors Composed of Copper Nanostructures for Diabetes Management: A Critical Review." Bioengineering & Translational Medicine , no. : e10248.
Fungal infections, from mild itching to fatal infections, lead to chronic diseases and death. Antifungal agents have incorporated chemical compounds and natural products/phytoconstituents in the management of fungal diseases. In contrast to antibacterial research, novel antifungal drugs have progressed more swiftly because of their mild existence and negligible resistance of infections to antifungal bioactivities. Nanotechnology-based carriers have gained much attention due to their magnificent abilities. Nanoarchitectures have served as excellent carriers/drug delivery systems (DDS) for delivering antifungal drugs with improved antifungal activities, bioavailability, targeted action, and reduced cytotoxicity. This review outlines the different fungal diseases and their treatment strategies involving various nanocarrier-based techniques such as liposomes, transfersomes, ethosomes, transethosomes, niosomes, spanlastics, dendrimers, polymeric nanoparticles, polymer nanocomposites, metallic nanoparticles, carbon nanomaterials, and nanoemulsions, among other nanotechnological approaches.
Vijay Mishra; Manvendra Singh; Yachana Mishra; Nitin Charbe; Pallavi Nayak; Kalvatala Sudhakar; Alaa Aljabali; Seyed Shahcheraghi; Hamid Bakshi; Ángel Serrano-Aroca; Murtaza Tambuwala. Nanoarchitectures in Management of Fungal Diseases: An Overview. Applied Sciences 2021, 11, 7119 .
AMA StyleVijay Mishra, Manvendra Singh, Yachana Mishra, Nitin Charbe, Pallavi Nayak, Kalvatala Sudhakar, Alaa Aljabali, Seyed Shahcheraghi, Hamid Bakshi, Ángel Serrano-Aroca, Murtaza Tambuwala. Nanoarchitectures in Management of Fungal Diseases: An Overview. Applied Sciences. 2021; 11 (15):7119.
Chicago/Turabian StyleVijay Mishra; Manvendra Singh; Yachana Mishra; Nitin Charbe; Pallavi Nayak; Kalvatala Sudhakar; Alaa Aljabali; Seyed Shahcheraghi; Hamid Bakshi; Ángel Serrano-Aroca; Murtaza Tambuwala. 2021. "Nanoarchitectures in Management of Fungal Diseases: An Overview." Applied Sciences 11, no. 15: 7119.
The devastating impact of the ongoing coronavirus disease 2019 (COVID-19) on public health, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has made fighting of the COVID-19 pandemic is a top priority in medical research and pharmaceutical development. Surveillance of SARS-CoV-2 mutations is essential for the comprehension of SARS-CoV-2 variant diversity and their impact on virulence and pathogenicity. The SARS-CoV-2 open reading frame 10 (ORF10) protein interacts with multiple human proteins CUL2, ELOB, ELOC, MAP7D1, PPT1, RBX1, THTPA, TIMM8B, and ZYG11B expressed in the lung tissues. Mutations and co-mutations in the emerging SARS-CoV-2 ORF10 variants are expected to impact the severity of the virus and its associated consequences. In this article, We highlight 128 single mutations and 35 co-mutations in the unique SARS-CoV-2 ORF10 variants in this article. The possible predicted effects of these mutations and co-mutations on the secondary structure of ORF10 variants and host protein interactomes are presented. The findings highlight the possible effects of mutations and co-mutations on the emerging 140 ORF10 unique variants from secondary structure and intrinsic protein disorder perspectives.
Sk. Sarif Hassan; Kenneth Lundstrom; Ángel Serrano-Aroca; Parise Adadi; Alaa Aljabali; ElRashdy Redwan; Amos Lal; Ramesh Kandimalla; Tarek El-Aziz; Pabitra Choudhury; Gajendra Azad; Samendra Sherchan; Murtaza Tambuwala; Gaurav Chauhan; Kazuo Takayama; Debmalya Barh; Giorgio Palù; Pallab Basu; Vladimir N Uversky. Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function. 2021, 1 .
AMA StyleSk. Sarif Hassan, Kenneth Lundstrom, Ángel Serrano-Aroca, Parise Adadi, Alaa Aljabali, ElRashdy Redwan, Amos Lal, Ramesh Kandimalla, Tarek El-Aziz, Pabitra Choudhury, Gajendra Azad, Samendra Sherchan, Murtaza Tambuwala, Gaurav Chauhan, Kazuo Takayama, Debmalya Barh, Giorgio Palù, Pallab Basu, Vladimir N Uversky. Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function. . 2021; ():1.
Chicago/Turabian StyleSk. Sarif Hassan; Kenneth Lundstrom; Ángel Serrano-Aroca; Parise Adadi; Alaa Aljabali; ElRashdy Redwan; Amos Lal; Ramesh Kandimalla; Tarek El-Aziz; Pabitra Choudhury; Gajendra Azad; Samendra Sherchan; Murtaza Tambuwala; Gaurav Chauhan; Kazuo Takayama; Debmalya Barh; Giorgio Palù; Pallab Basu; Vladimir N Uversky. 2021. "Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function." , no. : 1.
Elrashdy M. Redwan; Mohammed F. Alghamdi; Tarek Mohamed Abd El-Aziz; Parise Adadi; Alaa A.A. Aljabali; Diksha Attrish; Gajendra Kumar Azad; Wagner Baetas-Da-Cruz; Debmalya Barh; Nicolas G. Bazan; Adam M. Brufsky; Gaurav Chauhan; S.K. Sarif Hassan; Ramesh Kandimalla; Amos Lal; Kenneth Lundstrom; Yogendra Kumar Mishra; Pabitra Pal Choudhury; Giorgio Palù; Pritam K. Panda; Damiano Pizzol; Nima Rezaei; Ángel Serrano-Aroca; Samendra P. Sherchan; Murat Seyran; Kazuo Takayama; Murtaza M. Tambuwala; Bruce D. Uhal; Vladimir N. Uversky. The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19. Autoimmunity Reviews 2021, 20, 102909 -102909.
AMA StyleElrashdy M. Redwan, Mohammed F. Alghamdi, Tarek Mohamed Abd El-Aziz, Parise Adadi, Alaa A.A. Aljabali, Diksha Attrish, Gajendra Kumar Azad, Wagner Baetas-Da-Cruz, Debmalya Barh, Nicolas G. Bazan, Adam M. Brufsky, Gaurav Chauhan, S.K. Sarif Hassan, Ramesh Kandimalla, Amos Lal, Kenneth Lundstrom, Yogendra Kumar Mishra, Pabitra Pal Choudhury, Giorgio Palù, Pritam K. Panda, Damiano Pizzol, Nima Rezaei, Ángel Serrano-Aroca, Samendra P. Sherchan, Murat Seyran, Kazuo Takayama, Murtaza M. Tambuwala, Bruce D. Uhal, Vladimir N. Uversky. The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19. Autoimmunity Reviews. 2021; 20 (10):102909-102909.
Chicago/Turabian StyleElrashdy M. Redwan; Mohammed F. Alghamdi; Tarek Mohamed Abd El-Aziz; Parise Adadi; Alaa A.A. Aljabali; Diksha Attrish; Gajendra Kumar Azad; Wagner Baetas-Da-Cruz; Debmalya Barh; Nicolas G. Bazan; Adam M. Brufsky; Gaurav Chauhan; S.K. Sarif Hassan; Ramesh Kandimalla; Amos Lal; Kenneth Lundstrom; Yogendra Kumar Mishra; Pabitra Pal Choudhury; Giorgio Palù; Pritam K. Panda; Damiano Pizzol; Nima Rezaei; Ángel Serrano-Aroca; Samendra P. Sherchan; Murat Seyran; Kazuo Takayama; Murtaza M. Tambuwala; Bruce D. Uhal; Vladimir N. Uversky. 2021. "The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19." Autoimmunity Reviews 20, no. 10: 102909-102909.
The mortality and morbidity rates for prostate cancer have recently increased to alarming levels, rising higher than lung cancer. Due to a lack of drug targets and molecular probes, existing theranostic techniques are limited. Human LIN28A and its paralog LIN28B overexpression are associated with a number of tumors resulting in a remarkable increase in cancer aggression and poor prognoses. The current review aims to highlight recent work identifying the key roles of LIN28A and LIN28B in prostate cancer, and to instigate further preclinical and clinical research in this important area.
Garima Shrivastava; Alaa Aa Aljabali; Seyed Hossein Shahcheraghi; Marzieh Lotfi; Madhur D Shastri; Shakti D Shukla; Dinesh K Chellappan; Niraj Kumar Jha; Krishnan Anand; Harish Dureja; Ritesh M Pabari; Vijay Mishra; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Nitin Charbe; Parteek Prasher; Poonam Negi; Rohit Goyal; Kamal Dua; Gaurav Gupta; Ángel Serrano-Aroca; Bojlul Bahar; Debmalya Barh; Pritam Kumar Panda; Kazuo Takayama; Kenneth Lundstorm; Paul McCarron; Hamid Bakshi; Murtaza M Tambuwala. Targeting LIN28: a new hope in prostate cancer theranostics. Future Oncology 2021, 1 .
AMA StyleGarima Shrivastava, Alaa Aa Aljabali, Seyed Hossein Shahcheraghi, Marzieh Lotfi, Madhur D Shastri, Shakti D Shukla, Dinesh K Chellappan, Niraj Kumar Jha, Krishnan Anand, Harish Dureja, Ritesh M Pabari, Vijay Mishra, Abdulmajeed G Almutary, Abdullah M Alnuqaydan, Nitin Charbe, Parteek Prasher, Poonam Negi, Rohit Goyal, Kamal Dua, Gaurav Gupta, Ángel Serrano-Aroca, Bojlul Bahar, Debmalya Barh, Pritam Kumar Panda, Kazuo Takayama, Kenneth Lundstorm, Paul McCarron, Hamid Bakshi, Murtaza M Tambuwala. Targeting LIN28: a new hope in prostate cancer theranostics. Future Oncology. 2021; ():1.
Chicago/Turabian StyleGarima Shrivastava; Alaa Aa Aljabali; Seyed Hossein Shahcheraghi; Marzieh Lotfi; Madhur D Shastri; Shakti D Shukla; Dinesh K Chellappan; Niraj Kumar Jha; Krishnan Anand; Harish Dureja; Ritesh M Pabari; Vijay Mishra; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Nitin Charbe; Parteek Prasher; Poonam Negi; Rohit Goyal; Kamal Dua; Gaurav Gupta; Ángel Serrano-Aroca; Bojlul Bahar; Debmalya Barh; Pritam Kumar Panda; Kazuo Takayama; Kenneth Lundstorm; Paul McCarron; Hamid Bakshi; Murtaza M Tambuwala. 2021. "Targeting LIN28: a new hope in prostate cancer theranostics." Future Oncology , no. : 1.
Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and Ad26.COV2.S, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19). Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the CD46 receptor or platelet factor 4 antibodies. Similar findings have been reported for several viral diseases after vaccine administration. In addition, immunological mechanisms elicited by viral vectors related to cellular delivery could play a relevant role in individuals with certain genetic backgrounds. Although rare, the potential COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) requires immediate validation, especially in risk groups, such as the elderly, chronic smokers, and individuals with pre-existing incidences of thrombocytopenia; and if necessary, a reformulation of existing vaccines.
Kenneth Lundstrom; Debmalya Barh; Bruce Uhal; Kazuo Takayama; Alaa Aljabali; Tarek Abd El-Aziz; Amos Lal; ElRashdy Redwan; Parise Adadi; Gaurav Chauhan; Samendra Sherchan; Gajendra Azad; Nima Rezaei; Ángel Serrano-Aroca; Nicolas Bazan; Sk Hassan; Pritam Panda; Pabitra Pal Choudhury; Damiano Pizzol; Ramesh Kandimalla; Wagner Baetas-Da-Cruz; Yogendra Mishra; Giorgio Palu; Adam Brufsky; Murtaza Tambuwala; Vladimir Uversky. COVID-19 Vaccines and Thrombosis—Roadblock or Dead-End Street? Biomolecules 2021, 11, 1020 .
AMA StyleKenneth Lundstrom, Debmalya Barh, Bruce Uhal, Kazuo Takayama, Alaa Aljabali, Tarek Abd El-Aziz, Amos Lal, ElRashdy Redwan, Parise Adadi, Gaurav Chauhan, Samendra Sherchan, Gajendra Azad, Nima Rezaei, Ángel Serrano-Aroca, Nicolas Bazan, Sk Hassan, Pritam Panda, Pabitra Pal Choudhury, Damiano Pizzol, Ramesh Kandimalla, Wagner Baetas-Da-Cruz, Yogendra Mishra, Giorgio Palu, Adam Brufsky, Murtaza Tambuwala, Vladimir Uversky. COVID-19 Vaccines and Thrombosis—Roadblock or Dead-End Street? Biomolecules. 2021; 11 (7):1020.
Chicago/Turabian StyleKenneth Lundstrom; Debmalya Barh; Bruce Uhal; Kazuo Takayama; Alaa Aljabali; Tarek Abd El-Aziz; Amos Lal; ElRashdy Redwan; Parise Adadi; Gaurav Chauhan; Samendra Sherchan; Gajendra Azad; Nima Rezaei; Ángel Serrano-Aroca; Nicolas Bazan; Sk Hassan; Pritam Panda; Pabitra Pal Choudhury; Damiano Pizzol; Ramesh Kandimalla; Wagner Baetas-Da-Cruz; Yogendra Mishra; Giorgio Palu; Adam Brufsky; Murtaza Tambuwala; Vladimir Uversky. 2021. "COVID-19 Vaccines and Thrombosis—Roadblock or Dead-End Street?" Biomolecules 11, no. 7: 1020.
Background: Silver nanoparticles (AgNPs) are among the most investigated nanostructures in recent years, which exhibit more challenging and promising qualities in different biomedical applications. The AgNPs synthesized by the green approach provide potential healthcare benefits over chemical approaches, including improvement of tissue restoration, drug delivery, diagnosis, being environmentally friendly, and a boon to cancer treatment. Objective: In the current scenario, the development of safe and effective drug delivery systems is the utmost concern of formulation development scientists as well as clinicians. Methods: Google, Web of Science, and PubMed portals have been searched for potentially relevant literature to get the latest developments and updated information related to different aspects of green synthesized AgNPs along with their biomedical applications, especially in the treatment of different types of cancers. Results: The present review highlights the latest published research regarding the different green approaches for the synthesis of AgNPs, their characterization techniques as well as various biomedical applications, particularly in cancer treatment. In this context, environment-friendly AgNPs are proving themselves as better candidates in terms of size, drug loading and release efficiency, targeting efficiency, minimal drug-associated side effects, pharmacokinetic profiling, and biocompatibility issues. Conclusion: With continuous efforts by multidisciplinary team approaches, nanotechnology-based AgNPs will shed new light on diagnostics and therapeutics in various disease treatments. However, the toxicity issues of AgNPs need greater attention as unanticipated toxic effects must be ruled out for their diversified applications.
Vijay Mishra; Pallavi Nayak; Manvendra Singh; Murtaza M. Tambuwala; Alaa A. Aljabali; Dinesh K. Chellappan; Kamal Dua. Pharmaceutical Aspects of Green Synthesized Silver Nanoparticles: A Boon to Cancer Treatment. Anti-Cancer Agents in Medicinal Chemistry 2021, 21, 1490 -1509.
AMA StyleVijay Mishra, Pallavi Nayak, Manvendra Singh, Murtaza M. Tambuwala, Alaa A. Aljabali, Dinesh K. Chellappan, Kamal Dua. Pharmaceutical Aspects of Green Synthesized Silver Nanoparticles: A Boon to Cancer Treatment. Anti-Cancer Agents in Medicinal Chemistry. 2021; 21 (12):1490-1509.
Chicago/Turabian StyleVijay Mishra; Pallavi Nayak; Manvendra Singh; Murtaza M. Tambuwala; Alaa A. Aljabali; Dinesh K. Chellappan; Kamal Dua. 2021. "Pharmaceutical Aspects of Green Synthesized Silver Nanoparticles: A Boon to Cancer Treatment." Anti-Cancer Agents in Medicinal Chemistry 21, no. 12: 1490-1509.
Several hypotheses have been presented on the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from its identification as the agent causing the current coronavirus disease 19 (COVID-19) pandemic. So far, no hypothesis has managed to identify the origin, and the issue has resurfaced. Here we have unfolded a pattern of distribution of several mutations in the SARS-CoV-2 proteins across different continents comprising 24 geo-locations. The results showed an evenly uneven distribution of unique protein variants, distinct mutations, unique frequency of common conserved residues, and mutational residues across the 24 geo-locations. Furthermore, ample mutations were identified in the evolutionarily conserved invariant regions in the SARS-CoV-2 proteins across almost all geo-locations we have considered. This pattern of mutations potentially breaches the law of evolutionary conserved functional units of the beta-coronavirus genus. These mutations may lead to several novel SARS-CoV-2 variants with a high degree of transmissibility and virulence. A thorough investigation on the origin and characteristics of SARS-CoV-2 needs to be conducted in the interest of science and to be prepared to meet the challenges of potential future pandemics.
Sk Sarif Hassan; Vaishnavi Kodakandla; Elrashdy M. Redwan; Kenneth Lundstrom; Pabitra Pal Choudhury; Ángel Serrano-Aroca Aroca; Gajendra Kumar Azad; Alaa A.A. Aljabali; Giorgio Palu; Tarek Mohamed Abd El-Aziz; Debmalya Barh; Bruce D. Uhal; Parise Adadi; Kazuo Takayama; Nicolas G. Bazan; Murtaza Tambuwala; Samendra P. Sherchan; Amos Lal; Gaurav Chauhan; Wagner Baetas-Da-Cruz; Vladimir N. Uversky. Non-Uniform Aspects of SARS-CoV-2 Intraspecies Evolution Reopen Questions on Its Origin. 2021, 1 .
AMA StyleSk Sarif Hassan, Vaishnavi Kodakandla, Elrashdy M. Redwan, Kenneth Lundstrom, Pabitra Pal Choudhury, Ángel Serrano-Aroca Aroca, Gajendra Kumar Azad, Alaa A.A. Aljabali, Giorgio Palu, Tarek Mohamed Abd El-Aziz, Debmalya Barh, Bruce D. Uhal, Parise Adadi, Kazuo Takayama, Nicolas G. Bazan, Murtaza Tambuwala, Samendra P. Sherchan, Amos Lal, Gaurav Chauhan, Wagner Baetas-Da-Cruz, Vladimir N. Uversky. Non-Uniform Aspects of SARS-CoV-2 Intraspecies Evolution Reopen Questions on Its Origin. . 2021; ():1.
Chicago/Turabian StyleSk Sarif Hassan; Vaishnavi Kodakandla; Elrashdy M. Redwan; Kenneth Lundstrom; Pabitra Pal Choudhury; Ángel Serrano-Aroca Aroca; Gajendra Kumar Azad; Alaa A.A. Aljabali; Giorgio Palu; Tarek Mohamed Abd El-Aziz; Debmalya Barh; Bruce D. Uhal; Parise Adadi; Kazuo Takayama; Nicolas G. Bazan; Murtaza Tambuwala; Samendra P. Sherchan; Amos Lal; Gaurav Chauhan; Wagner Baetas-Da-Cruz; Vladimir N. Uversky. 2021. "Non-Uniform Aspects of SARS-CoV-2 Intraspecies Evolution Reopen Questions on Its Origin." , no. : 1.
Smart electronic materials ‘nanographene’ stated, its significant authentication has undergone massive improvements and has emerged as a ‘material of the century’ in materialize fields of ‘Chemical Biology’ and ‘Materials Chemistry’. ‘Graphene’ as a wonder material has been proposed to possess a high surface area (∼2600 m2 g−1), high portability of charge carriers and excellent mechanical qualities. Moreover, the long-extend π-conjugation of graphene is an essential photocatalytic property enabling wide ranging biosensor activities. Herein, critical review article reflects well known yet a brand-new novel material ‘nanographene’ and its versatile integrations, utilized for substantial enrichment of desired properties. Target cost-effectiveness, plasticity, and environment-friendliness of melt mixing/compounding fabrication strategy employed to utilize in-vivo, in-vitro, and in- situ, pharmaceutical, nano-imaging protocols. Owing to nanographene’s wide range expansion, summarized latest breakthroughs in Materials Science as well as Biomedical utilizations including cancer nanotechnology, drug delivery, tissue manufacturing, scaffold, photo-thermal therapy, antimicrobial activities, made up of exploring the significant opportunities and key challenges in this novel emerging field.
Kaushik Pal; Nidhi Asthana; Alaa A Aljabali; Sheetal K. Bhardwaj; Samo Kralj; Anastasia Penkova; Sabu Thomas; Tean Zaheer; Fernando Gomes de Souza. A critical review on multifunctional smart materials ‘nanographene’ emerging avenue: nano-imaging and biosensor applications. Critical Reviews in Solid State and Materials Sciences 2021, 1 -17.
AMA StyleKaushik Pal, Nidhi Asthana, Alaa A Aljabali, Sheetal K. Bhardwaj, Samo Kralj, Anastasia Penkova, Sabu Thomas, Tean Zaheer, Fernando Gomes de Souza. A critical review on multifunctional smart materials ‘nanographene’ emerging avenue: nano-imaging and biosensor applications. Critical Reviews in Solid State and Materials Sciences. 2021; ():1-17.
Chicago/Turabian StyleKaushik Pal; Nidhi Asthana; Alaa A Aljabali; Sheetal K. Bhardwaj; Samo Kralj; Anastasia Penkova; Sabu Thomas; Tean Zaheer; Fernando Gomes de Souza. 2021. "A critical review on multifunctional smart materials ‘nanographene’ emerging avenue: nano-imaging and biosensor applications." Critical Reviews in Solid State and Materials Sciences , no. : 1-17.
Background: Nature had already engineered various types of nanoparticles (NPs), especially viruses, which can deliver their cargo to the host/targeted cells. The ability to selectively target specific cells offers a significant advantage over the conventional approach. Numerous organic NPs, including native protein cages, virus-like pieces, polymeric saccharides, and liposomes, have been used for the preparation of nanoparticulate. Such nanomaterials have demonstrated better performance and as well as improved biocompatible, devoid of side effects, and stable without any deterioration. Objective: This review discusses current clinical and scientific research on naturally occurring nanomaterials. The review illustrates and updates the tailor-made approaches for selective delivery and targeted medications that require a highaffinity interconnection to the targeted cells. Method: A comprehensive search was performed using keywords for viral nanoparticles, viral particles for drug delivery, viral nanoparticles for molecular imaging, theranostics applications of viral nanoparticles and plant viruses in nanomedicine. We searched in Google Scholar, PubMed, Springer, Medline, and Elsevier from 2000 to till date and by the bibliographic review of all identified articles. Results: The findings demonstrated that structures dependent on nanomaterials might have potential applications in diagnostics, cell marking, comparing agents (computed tomography and magnetic resonance imaging), and antimicrobial drugs, as well as drug delivery structures. However, measures should be taken in order to prevent or mitigate in pharmaceutical or medical applications the toxic impact or incompatibility of nanoparticle-based structures with biological systems. Conclusion: The review provided an overview of the latest advances in nanotechnology, outlining the difficulties and the advantages of in vivo and in vitro structures that are focused on a specific subset of the natural nanomaterials.
Alaa A.A. Aljabali; Mazhar S. Al Zoubi; Khalid M. Al-Batayneh; Dinesh M. Pardhi; Kamal Dua; Kaushik Pal; Murtaza M. Tambuwala. Innovative Applications of Plant Viruses in Drug Targeting and Molecular Imaging- A Review. Current Medical Imaging Formerly Current Medical Imaging Reviews 2021, 17, 491 -506.
AMA StyleAlaa A.A. Aljabali, Mazhar S. Al Zoubi, Khalid M. Al-Batayneh, Dinesh M. Pardhi, Kamal Dua, Kaushik Pal, Murtaza M. Tambuwala. Innovative Applications of Plant Viruses in Drug Targeting and Molecular Imaging- A Review. Current Medical Imaging Formerly Current Medical Imaging Reviews. 2021; 17 (4):491-506.
Chicago/Turabian StyleAlaa A.A. Aljabali; Mazhar S. Al Zoubi; Khalid M. Al-Batayneh; Dinesh M. Pardhi; Kamal Dua; Kaushik Pal; Murtaza M. Tambuwala. 2021. "Innovative Applications of Plant Viruses in Drug Targeting and Molecular Imaging- A Review." Current Medical Imaging Formerly Current Medical Imaging Reviews 17, no. 4: 491-506.
It is well established that pre-existing comorbid conditions such as hypertension, diabetes, obesity, cardiovascular diseases (CVDs), chronic kidney diseases (CKDs), cancers, and chronic obstructive pulmonary disease (COPD) are associated with increased severity and fatality of COVID-19. The increased death from COVID-19 is due to the unavailability of a gold standard therapeutic and, more importantly, the lack of understanding of how the comorbid conditions and COVID-19 interact at the molecular level, so that personalized management strategies can be adopted. Here, using multi-omics data sets and bioinformatics strategy, we identified the pathway crosstalk between COVID-19 and diabetes, hypertension, CVDs, CKDs, and cancers. Further, shared pathways and hub gene-based targets for COVID-19 and its associated specific and combination of comorbid conditions are also predicted towards developing personalized management strategies. The approved drugs for most of these identified targets are also provided towards drug repurposing. Literature supports the involvement of our identified shared pathways in pathogenesis of COVID-19 and development of the specific comorbid condition of interest. Similarly, shared pathways- and hub gene-based targets are also found to have potential implementations in managing COVID-19 patients. However, the identified targets and drugs need further careful evaluation for their repurposing towards personalized treatment of COVID-19 cases having pre-existing specific comorbid conditions we have considered in this analysis. The method applied here may also be helpful in identifying common pathway components and targets in other disease-disease interactions too.
Debmalya Barh; Alaa Aljabali; Murtaza Tambuwala; Sandeep Tiwari; Ángel Serrano-Aroca; Khalid Alzahrani; Bruno Silva Andrade; Vasco Azevedo; Nirmal Ganguly; Kenneth Lundstrom. Predicting COVID-19—Comorbidity Pathway Crosstalk-Based Targets and Drugs: Towards Personalized COVID-19 Management. Biomedicines 2021, 9, 556 .
AMA StyleDebmalya Barh, Alaa Aljabali, Murtaza Tambuwala, Sandeep Tiwari, Ángel Serrano-Aroca, Khalid Alzahrani, Bruno Silva Andrade, Vasco Azevedo, Nirmal Ganguly, Kenneth Lundstrom. Predicting COVID-19—Comorbidity Pathway Crosstalk-Based Targets and Drugs: Towards Personalized COVID-19 Management. Biomedicines. 2021; 9 (5):556.
Chicago/Turabian StyleDebmalya Barh; Alaa Aljabali; Murtaza Tambuwala; Sandeep Tiwari; Ángel Serrano-Aroca; Khalid Alzahrani; Bruno Silva Andrade; Vasco Azevedo; Nirmal Ganguly; Kenneth Lundstrom. 2021. "Predicting COVID-19—Comorbidity Pathway Crosstalk-Based Targets and Drugs: Towards Personalized COVID-19 Management." Biomedicines 9, no. 5: 556.
The current Coronavirus Disease 19 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) shows similar pathology to MERS and SARS-CoV, with a current estimated fatality rate of 1.4%. Open reading frame 10 (ORF10) is a unique SARS-CoV-2 accessory protein, which contains eleven cytotoxic T lymphocyte (CTL) epitopes each of nine amino acids in length. Twenty-two unique SARS-CoV-2 ORF10 variants have been identified based on missense mutations found in sequence databases. Some of these mutations are predicted to decrease the stability of ORF10 in silico physicochemical and structural comparative analyses were carried out on SARS-CoV-2 and Pangolin-CoV ORF10 proteins, which share 97.37% amino acid (aa) homology. Though there is a high degree of ORF10 protein similarity of SARS-CoV-2 and Pangolin-CoV, there are differences of these two ORF10 proteins related to their sub-structure (loop/coil region), solubility, antigenicity and shift from strand to coil at aa position 26 (tyrosine). SARS-CoV-2 ORF10, which is apparently expressed in vivo since reactive T cell clones are found in convalescent patients should be monitored for changes which could correlate with the pathogenesis of COVID-19.
Sk. Sarif Hassan; Diksha Attrish; Shinjini Ghosh; Pabitra Pal Choudhury; Vladimir N. Uversky; Alaa A.A. Aljabali; Kenneth Lundstrom; Bruce D. Uhal; Nima Rezaei; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M. Tambuwala; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Amos Lal; Giorgio Palù; Kazuo Takayama; Ángel Serrano-Aroca; Debmalya Barh; Adam M. Brufsky. Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2. International Journal of Biological Macromolecules 2021, 181, 801 -809.
AMA StyleSk. Sarif Hassan, Diksha Attrish, Shinjini Ghosh, Pabitra Pal Choudhury, Vladimir N. Uversky, Alaa A.A. Aljabali, Kenneth Lundstrom, Bruce D. Uhal, Nima Rezaei, Murat Seyran, Damiano Pizzol, Parise Adadi, Antonio Soares, Tarek Mohamed Abd El-Aziz, Ramesh Kandimalla, Murtaza M. Tambuwala, Gajendra Kumar Azad, Samendra P. Sherchan, Wagner Baetas-Da-Cruz, Amos Lal, Giorgio Palù, Kazuo Takayama, Ángel Serrano-Aroca, Debmalya Barh, Adam M. Brufsky. Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2. International Journal of Biological Macromolecules. 2021; 181 ():801-809.
Chicago/Turabian StyleSk. Sarif Hassan; Diksha Attrish; Shinjini Ghosh; Pabitra Pal Choudhury; Vladimir N. Uversky; Alaa A.A. Aljabali; Kenneth Lundstrom; Bruce D. Uhal; Nima Rezaei; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M. Tambuwala; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Amos Lal; Giorgio Palù; Kazuo Takayama; Ángel Serrano-Aroca; Debmalya Barh; Adam M. Brufsky. 2021. "Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2." International Journal of Biological Macromolecules 181, no. : 801-809.
Therapeutic options for the highly pathogenic human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the current pandemic coronavirus disease (COVID-19) are urgently needed. COVID-19 is associated with viral pneumonia and acute respiratory distress syndrome causing significant morbidity and mortality. The proposed treatments for COVID-19 have shown little or no effect in the clinic so far. Additionally, bacterial and fungal pathogens contribute to the SARS-CoV-2-mediated pneumonia disease complex. The antibiotic resistance in pneumonia treatment is increasing at an alarming rate. Therefore, carbon-based nanomaterials (CBNs), such as fullerene, carbon dots, graphene, and their derivatives constitute a promising alternative due to their wide-spectrum antimicrobial activity, biocompatibility, biodegradability, and capacity to induce tissue regeneration. Furthermore, the antimicrobial mode of action is mainly physical (e.g., membrane distortion), characterized by a low risk of antimicrobial resistance. In this Review, we evaluated the literature on the antiviral activity and broad-spectrum antimicrobial properties of CBNs. CBNs had antiviral activity against 13 enveloped positive-sense single-stranded RNA viruses, including SARS-CoV-2. CBNs with low or no toxicity to humans are promising therapeutics against the COVID-19 pneumonia complex with other viruses, bacteria, and fungi, including those that are multidrug-resistant.
Ángel Serrano-Aroca; Kazuo Takayama; Alberto Tuñón-Molina; Murat Seyran; Sk. Sarif Hassan; Pabitra Pal Choudhury; Vladimir N. Uversky; Kenneth Lundstrom; Parise Adadi; Giorgio Palù; Alaa A. A. Aljabali; Gaurav Chauhan; Ramesh Kandimalla; Murtaza M. Tambuwala; Amos Lal; Tarek Mohamed Abd El-Aziz; Samendra Sherchan; Debmalya Barh; Elrashdy M. Redwan; Nicolas G. Bazan; Yogendra Kumar Mishra; Bruce D. Uhal; Adam Brufsky. Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era. ACS Nano 2021, 15, 8069 -8086.
AMA StyleÁngel Serrano-Aroca, Kazuo Takayama, Alberto Tuñón-Molina, Murat Seyran, Sk. Sarif Hassan, Pabitra Pal Choudhury, Vladimir N. Uversky, Kenneth Lundstrom, Parise Adadi, Giorgio Palù, Alaa A. A. Aljabali, Gaurav Chauhan, Ramesh Kandimalla, Murtaza M. Tambuwala, Amos Lal, Tarek Mohamed Abd El-Aziz, Samendra Sherchan, Debmalya Barh, Elrashdy M. Redwan, Nicolas G. Bazan, Yogendra Kumar Mishra, Bruce D. Uhal, Adam Brufsky. Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era. ACS Nano. 2021; 15 (5):8069-8086.
Chicago/Turabian StyleÁngel Serrano-Aroca; Kazuo Takayama; Alberto Tuñón-Molina; Murat Seyran; Sk. Sarif Hassan; Pabitra Pal Choudhury; Vladimir N. Uversky; Kenneth Lundstrom; Parise Adadi; Giorgio Palù; Alaa A. A. Aljabali; Gaurav Chauhan; Ramesh Kandimalla; Murtaza M. Tambuwala; Amos Lal; Tarek Mohamed Abd El-Aziz; Samendra Sherchan; Debmalya Barh; Elrashdy M. Redwan; Nicolas G. Bazan; Yogendra Kumar Mishra; Bruce D. Uhal; Adam Brufsky. 2021. "Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era." ACS Nano 15, no. 5: 8069-8086.
Azole frameworks serve as privileged scaffolds in the contemporary drug design paradigm owing to their unique physicochemical profile that promotes the development of highly selective, physiological benevolent chemotherapeutics. Several azole nuclei function as bioisostere in medicinal chemistry and prompt the development of tailored therapeutics for targeting the desired biological entities. Besides, the azole scaffold forms an integral part in the advanced drug designing methodologies, such as target template insitu drug synthesis, that assists in rapid identification of the hit molecules form a diverse pool of leads; and direct biomolecule-drug conjugation, along with bioorthogonal strategies that ensure localization, and superior target specificity of the directed therapeutic. Lastly, the structural diversity of azole framework and high yielding click synthetic methods provide a comprehensive Structure-Activity Relationship analysis for design optimization of the potential drug molecules by fine-tuning the placement of different substituents critical for the activity. This review provides a comprehensive analysis of the synthesis and anticancer potential of azole based chemotherapeutics.
Parteek Prasher; Mousmee Sharma; Flavia Zacconi; Gaurav Gupta; Alaa A.A. Aljabali; Vijay Mishra; Murtaza M. Tambuwala; Deepak N. Kapoor; Poonam Negi; Terezinha De Jesus Andreoli Pinto; Inderbir Singh; Dinesh K. Chellappan; Kamal Dua. Synthesis and Anticancer Properties of ‘Azole’ Based Chemotherapeutics as Emerging Chemical Moieties: A Comprehensive Review. Current Organic Chemistry 2021, 25, 654 -668.
AMA StyleParteek Prasher, Mousmee Sharma, Flavia Zacconi, Gaurav Gupta, Alaa A.A. Aljabali, Vijay Mishra, Murtaza M. Tambuwala, Deepak N. Kapoor, Poonam Negi, Terezinha De Jesus Andreoli Pinto, Inderbir Singh, Dinesh K. Chellappan, Kamal Dua. Synthesis and Anticancer Properties of ‘Azole’ Based Chemotherapeutics as Emerging Chemical Moieties: A Comprehensive Review. Current Organic Chemistry. 2021; 25 (6):654-668.
Chicago/Turabian StyleParteek Prasher; Mousmee Sharma; Flavia Zacconi; Gaurav Gupta; Alaa A.A. Aljabali; Vijay Mishra; Murtaza M. Tambuwala; Deepak N. Kapoor; Poonam Negi; Terezinha De Jesus Andreoli Pinto; Inderbir Singh; Dinesh K. Chellappan; Kamal Dua. 2021. "Synthesis and Anticancer Properties of ‘Azole’ Based Chemotherapeutics as Emerging Chemical Moieties: A Comprehensive Review." Current Organic Chemistry 25, no. 6: 654-668.
Phylogenetic analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is focused on a single isolate of bat coronaviruses (bat CoVs) which does not adequately represent genetically related coronaviruses (CoVs)
Murat Seyran; Sk. Hassan; Vladimir Uversky; Pabitra Pal Choudhury; Bruce Uhal; Kenneth Lundstrom; Diksha Attrish; Nima Rezaei; Alaa Aljabali; Shinjini Ghosh; Damiano Pizzol; Parise Adadi; Tarek El-Aziz; Ramesh Kandimalla; Murtaza Tambuwala; Amos Lal; Gajendra Azad; Samendra Sherchan; Wagner Baetas-Da-Cruz; Giorgio Palù; Adam Brufsky. Urgent Need for Field Surveys of Coronaviruses in Southeast Asia to Understand the SARS-CoV-2 Phylogeny and Risk Assessment for Future Outbreaks. Biomolecules 2021, 11, 398 .
AMA StyleMurat Seyran, Sk. Hassan, Vladimir Uversky, Pabitra Pal Choudhury, Bruce Uhal, Kenneth Lundstrom, Diksha Attrish, Nima Rezaei, Alaa Aljabali, Shinjini Ghosh, Damiano Pizzol, Parise Adadi, Tarek El-Aziz, Ramesh Kandimalla, Murtaza Tambuwala, Amos Lal, Gajendra Azad, Samendra Sherchan, Wagner Baetas-Da-Cruz, Giorgio Palù, Adam Brufsky. Urgent Need for Field Surveys of Coronaviruses in Southeast Asia to Understand the SARS-CoV-2 Phylogeny and Risk Assessment for Future Outbreaks. Biomolecules. 2021; 11 (3):398.
Chicago/Turabian StyleMurat Seyran; Sk. Hassan; Vladimir Uversky; Pabitra Pal Choudhury; Bruce Uhal; Kenneth Lundstrom; Diksha Attrish; Nima Rezaei; Alaa Aljabali; Shinjini Ghosh; Damiano Pizzol; Parise Adadi; Tarek El-Aziz; Ramesh Kandimalla; Murtaza Tambuwala; Amos Lal; Gajendra Azad; Samendra Sherchan; Wagner Baetas-Da-Cruz; Giorgio Palù; Adam Brufsky. 2021. "Urgent Need for Field Surveys of Coronaviruses in Southeast Asia to Understand the SARS-CoV-2 Phylogeny and Risk Assessment for Future Outbreaks." Biomolecules 11, no. 3: 398.
The COVID-19 pandemic continues to endanger world health and the economy. The causative SARS-CoV-2 coronavirus has a unique replication system. The end point of the COVID-19 pandemic is either herd immunity or widespread availability of an effective vaccine. Multiple candidate vaccines – peptide, virus-like particle, viral vectors (replicating and nonreplicating), nucleic acids (DNA or RNA), live attenuated virus, recombinant designed proteins and inactivated virus – are presently under various stages of expansion, and a small number of vaccine candidates have progressed into clinical phases. At the time of writing, three major pharmaceutical companies, namely Pfizer and Moderna, have their vaccines under mass production and administered to the public. This review aims to investigate the most critical vaccines developed for COVID-19 to date.
Seyed H Shahcheraghi; Jamshid Ayatollahi; Alaa Aa Aljabali; Madhur D Shastri; Shakti D Shukla; Dinesh K Chellappan; Niraj K Jha; Krishnan Anand; Naresh K Katari; Meenu Mehta; Saurabh Satija; Harish Dureja; Vijay Mishra; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Nitin Charbe; Parteek Prasher; Gaurav Gupta; Kamal Dua; Marzieh Lotfi; Hamid A Bakshi; Murtaza M Tambuwala. An overview of vaccine development for COVID-19. Therapeutic Delivery 2021, 12, 235 -244.
AMA StyleSeyed H Shahcheraghi, Jamshid Ayatollahi, Alaa Aa Aljabali, Madhur D Shastri, Shakti D Shukla, Dinesh K Chellappan, Niraj K Jha, Krishnan Anand, Naresh K Katari, Meenu Mehta, Saurabh Satija, Harish Dureja, Vijay Mishra, Abdulmajeed G Almutary, Abdullah M Alnuqaydan, Nitin Charbe, Parteek Prasher, Gaurav Gupta, Kamal Dua, Marzieh Lotfi, Hamid A Bakshi, Murtaza M Tambuwala. An overview of vaccine development for COVID-19. Therapeutic Delivery. 2021; 12 (3):235-244.
Chicago/Turabian StyleSeyed H Shahcheraghi; Jamshid Ayatollahi; Alaa Aa Aljabali; Madhur D Shastri; Shakti D Shukla; Dinesh K Chellappan; Niraj K Jha; Krishnan Anand; Naresh K Katari; Meenu Mehta; Saurabh Satija; Harish Dureja; Vijay Mishra; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Nitin Charbe; Parteek Prasher; Gaurav Gupta; Kamal Dua; Marzieh Lotfi; Hamid A Bakshi; Murtaza M Tambuwala. 2021. "An overview of vaccine development for COVID-19." Therapeutic Delivery 12, no. 3: 235-244.
Diabetic cardiomyopathy (DCM) can lead to left ventricular hypertrophy, diastolic dysfunction, and systolic dysfunction, or all of these. Gold nanoparticles (AuNPs) have shown anti-hyperglycemic effects in animal models of streptozotocin (STZ)-induced diabetes. This study was designed to address the effects of AuNPs on the animal model of DCM. twenty-two male adult rats were randomly categorized into 3 groups (n=6-8 / group): control (non-diabetic, ND), diabetic (D), and intraperitoneally treated diabetic rats with 50 nm AuNPs (D+AuNPs; 2,5 mg/kg/day). One single dose injection of 55 mg/kg STZ was used to induce diabetes in the animals. Blood and the left ventricle were collected after seven weeks for assessment. The myocardial mRNA and protein levels of transforming growth factor β1 (TGF-β1) and tumor necrosis factor-α (TNF-α) were evaluated using real-time PCR and immunohistochemistry. The myocardial mRNA level of vascular endothelial growth factor-A (VEGF-A) was measured using real-time PCR. Besides, the myocardial collagen deposition was measured by masson trichrome stain and immunohistochemistry. Rats with DCM showed hyperglycemia, increased myocardial mRNA and protein tissue content of TGF-β1, myocardial mRNA of VEGF-A (P < 0.05), and tended to increase myocardial mRNA and protein tissue content of TNF-α (P < 0.1). An increase in myocardial collagen deposition accompanied these changes. Treatment with AuNPs reduced the above pathological conditions. These results suggest that AuNPs may have therapeutic potential in the treatment of early DCM. Further studies are needed to explore the possible mechanisms by which AuNPs may prevent the development of DCM.
Alaa A A Aljabali; Bahaa Al-Trad; Lina Al Gazo; Ghada Alomari; Mazhar Al Zoubi; Walhan Alshaer; Khalid Al-Batayneh; Bahja Kanan; Kaushik Pal; Murtaza M. Tambuwala. Gold Nanoparticles Ameliorate Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats. Journal of Molecular Structure 2021, 1231, 130009 .
AMA StyleAlaa A A Aljabali, Bahaa Al-Trad, Lina Al Gazo, Ghada Alomari, Mazhar Al Zoubi, Walhan Alshaer, Khalid Al-Batayneh, Bahja Kanan, Kaushik Pal, Murtaza M. Tambuwala. Gold Nanoparticles Ameliorate Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats. Journal of Molecular Structure. 2021; 1231 ():130009.
Chicago/Turabian StyleAlaa A A Aljabali; Bahaa Al-Trad; Lina Al Gazo; Ghada Alomari; Mazhar Al Zoubi; Walhan Alshaer; Khalid Al-Batayneh; Bahja Kanan; Kaushik Pal; Murtaza M. Tambuwala. 2021. "Gold Nanoparticles Ameliorate Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats." Journal of Molecular Structure 1231, no. : 130009.
Therapeutic options for the highly pathogenic human Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) causing the current pandemic Coronavirus disease (COVID-19) are urgently needed. COVID-19 is associated with viral pneumonia and acute respiratory distress syndrome causing significant morbidity and mortality. The proposed treatments for COVID-19, such as hydroxychloroquine, remdesivir and lopinavir/ritonavir, have shown little or no effect in the clinic. Additionally, bacterial and fungal pathogens contribute to the SARS-CoV-2 mediated pneumonia disease complex. The antibiotic resistance in pneumonia treatment is increasing at an alarming rate. Therefore, carbon-based nanomaterials (CBNs), such as fullerene, carbon dots, graphene, and their derivatives constitute a promising alternative due to their wide-spectrum antimicrobial activity, biocompatibility, biodegradability and capacity to induce tissue regeneration. Furthermore, the antimicrobial mode of action is mainly physical (e.g. membrane distortion), which is characterized by a low risk of antimicrobial resistance. In this review, we evaluated the literature on the antiviral activity and broad-spectrum antimicrobial properties of CBNs. CBNs had antiviral activity against 12 enveloped positive-sense single-stranded RNA viruses similar to SARS-CoV-2. CBNs with low or no toxicity to the humans are promising therapeutics against COVID-19 pneumonia complex with other viruses, bacteria and fungi, including those that are multidrug-resistant.
Ángel Serrano-Aroca; Kazuo Takayama; Alberto Tuñón-Molina; Murat Seyran; Sk. Sarif Hassan; Pabitra Pal Choudhury; Vladimir N. Uversky; Kenneth Lundstrom; Parise Adadi; Giorgio Palù; Alaa A. A. Aljabali; Gaurav Chauhan; Ramesh Kandimalla; Murtaza M. Tambuwala; Amos Lal; Bruce D. Uhal; Adam M. Brufsky. Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial Resistant Era. 2021, 1 .
AMA StyleÁngel Serrano-Aroca, Kazuo Takayama, Alberto Tuñón-Molina, Murat Seyran, Sk. Sarif Hassan, Pabitra Pal Choudhury, Vladimir N. Uversky, Kenneth Lundstrom, Parise Adadi, Giorgio Palù, Alaa A. A. Aljabali, Gaurav Chauhan, Ramesh Kandimalla, Murtaza M. Tambuwala, Amos Lal, Bruce D. Uhal, Adam M. Brufsky. Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial Resistant Era. . 2021; ():1.
Chicago/Turabian StyleÁngel Serrano-Aroca; Kazuo Takayama; Alberto Tuñón-Molina; Murat Seyran; Sk. Sarif Hassan; Pabitra Pal Choudhury; Vladimir N. Uversky; Kenneth Lundstrom; Parise Adadi; Giorgio Palù; Alaa A. A. Aljabali; Gaurav Chauhan; Ramesh Kandimalla; Murtaza M. Tambuwala; Amos Lal; Bruce D. Uhal; Adam M. Brufsky. 2021. "Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial Resistant Era." , no. : 1.
Introduction: Oral administration of a drug is the most common, ideal and preferred route of administration. The main problem of oral drug formulations is their low bioavailability arises from poor aqueous solubility of drug. Aqueous solubility of lipophilic drugs can be improved by various techniques like salt formation, complexation, addition of co-solvent etc. but self-emulsifying drug delivery system (SEDDS) is getting more attention for increasing the solubility of such drugs. The SEDDS is an isotropic mixture of drug, lipids, and emulsifiers, usually with one or more hydrophilic co-solvents/co-emulsifiers. This system is having ability to generate oil-in-water (o/w) emulsions or microemulsions upon gentle agitation followed by dilution with aqueous phase. The SEDDSs are relatively newer, lipid-based technological innovations possessing unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. Areas covered: This review provides updated information regarding the types of SEDDS, their preparation techniques, drug delivery and related recent patents along with marketed formulations. Expert opinion: The SEDDS has been explored for improving bioavailability, rising intra-subject heterogeneity and increasing solubility. SEDDS offers the benefit of a protective effect against the hostile environment in the gut. The unique fabrication techniques provide specific strategy to overcome the low bioavailability and poor solubility problems.
Vijay Mishra; Pallavi Nayak; Nishika Yadav; Manvendra Singh; Murtaza M. Tambuwala; Alaa A. A. Aljabali. Orally administered self-emulsifying drug delivery system in disease management: advancement and patents. Expert Opinion on Drug Delivery 2020, 18, 315 -332.
AMA StyleVijay Mishra, Pallavi Nayak, Nishika Yadav, Manvendra Singh, Murtaza M. Tambuwala, Alaa A. A. Aljabali. Orally administered self-emulsifying drug delivery system in disease management: advancement and patents. Expert Opinion on Drug Delivery. 2020; 18 (3):315-332.
Chicago/Turabian StyleVijay Mishra; Pallavi Nayak; Nishika Yadav; Manvendra Singh; Murtaza M. Tambuwala; Alaa A. A. Aljabali. 2020. "Orally administered self-emulsifying drug delivery system in disease management: advancement and patents." Expert Opinion on Drug Delivery 18, no. 3: 315-332.
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.
Sk. Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Alaa A. A. Aljabali; Bruce D. Uhal; Kenneth Lundstrom; Nima Rezaei; Vladimir N. Uversky; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M. Tambuwala; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Kazuo Takayama; Ángel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Adam M. Brufsky. Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features. Molecules 2020, 25, 5906 .
AMA StyleSk. Sarif Hassan, Shinjini Ghosh, Diksha Attrish, Pabitra Pal Choudhury, Alaa A. A. Aljabali, Bruce D. Uhal, Kenneth Lundstrom, Nima Rezaei, Vladimir N. Uversky, Murat Seyran, Damiano Pizzol, Parise Adadi, Antonio Soares, Tarek Mohamed Abd El-Aziz, Ramesh Kandimalla, Murtaza M. Tambuwala, Gajendra Kumar Azad, Samendra P. Sherchan, Wagner Baetas-Da-Cruz, Kazuo Takayama, Ángel Serrano-Aroca, Gaurav Chauhan, Giorgio Palu, Adam M. Brufsky. Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features. Molecules. 2020; 25 (24):5906.
Chicago/Turabian StyleSk. Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Alaa A. A. Aljabali; Bruce D. Uhal; Kenneth Lundstrom; Nima Rezaei; Vladimir N. Uversky; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M. Tambuwala; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Kazuo Takayama; Ángel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Adam M. Brufsky. 2020. "Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features." Molecules 25, no. 24: 5906.