Background: Osteoarthritis (OA) is a chronic, debilitating, and degenerative joint disease. However, it is difficult for patients with knee OA to access conventional rehabilitation when discharging from the hospital. Internet-based rehabilitation is one of the promising telemedicine strategies to provide a means combining monitoring, guidance, and treatment for patients with knee OA. Objective: The aim of this study was to conduct a systematic review and meta-analysis for assessing the effect of internet-based rehabilitation programs on pain and physical function in patients with knee OA. Methods: Keywords related to knee OA and internet-based rehabilitation were systematically searched in the Web of Science, MEDLINE, EMBASE, CENTRAL, Scopus, PEDro (Physiotherapy Evidence Database), CNKI, SinoMed, and WANFANG databases from January 2000 to April 2020. Only randomized controlled trials were included. The authors independently screened the literature. The main outcome measures were focused on pain and physical function. A meta-analysis was performed on the collected data. Review Manager (RevMan, version 5.3) was used for all analyses. Results: The systematic review identified 6 randomized controlled trials, 4 of which were included in the meta-analysis, comprising a total of 791 patients with knee OA. The meta-analysis with the fixed-effects model showed that the internet-based rehabilitation programs could significantly alleviate the osteoarthritic pain for patients compared with conventional rehabilitation (standardized mean difference [SMD] –0.21, 95% CI −0.4 to –0.01, P=.04). No significant difference was found in the improvement of physical function in patients with knee OA compared with conventional rehabilitation within 2 to 12 months (SMD –0.08, 95% CI −0.27 to 0.12, P=.43). Conclusions: This systematic review shows that internet-based rehabilitation programs could improve the pain but not physical function for patients with knee OA. However, there was a very small number of studies that could be included in the review and meta-analysis. Thus, further studies with large sample sizes are warranted to promote the effectiveness of internet-based rehabilitation and to develop its personalized design.

Background: Myofascial pain syndrome (MPS) is a common musculoskeletal pain and dysfunction, which is characterised by myofascial trigger points. Therapeutic physical modalities, as potentially effective treatment options, are commonly used in the clinical setting for the patients with MPS. Objective: This systematic review aimed to evaluate the safety and effectiveness of therapeutic physical modalities in the treatment of MPS, investigate its therapeutic mechanisms and provide a scientific evidence-based decision. Methods: According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, the PubMed, Cochrane Central Library, Embase, and CINAHL databases were searched for randomized controlled clinical studies published from database inception to October 30, 2022. A total of 25 articles met the study inclusion criteria. Data were extracted from these studies and a qualitative analysis was performed. Results: Transcutaneous electrical nerve stimulation therapy, extracorporeal shock wave therapy, laser therapy, and other therapeutic physical modalities have been demonstrated to improve the pain symptoms, joint mobility, psychological state, and quality of life in the patients with MPS and no side effects have been reported. The curative effect of therapeutic physical modalities was found to be possibly associated with increased blood perfusion and oxygen supply in ischaemic tissues, reduced hyperalgesia in the peripheral and central nerves, and decreased involuntary muscle contractions. Conclusion: The systematic review has shown that therapeutic physical modalities could provide a safe and effective therapeutic option for MPS. However, the consensus is currently lacking regarding the optimal treatment paradigm, therapeutic parameters, and mutual combination of therapeutic physical modalities. The clinical trials with robust quality are required to further promote the evidence-based application of therapeutic physical modalities for MPS.

Pulsed electromagnetic field (PEMF) is a non-invasive physical therapy used in the treatment of fracture nonunion or delayed healing. PEMF can facilitate the osteogenic differentiation of bone marrow mesenchymal stem cells in vitro. Amniotic epithelial cells (AECs) have been proposed as a potential source of stem cells for cell therapy. However, whether PEMF could modulate the osteogenic differentiation of AECs is unknown. In the present study, the effects of PEMF on the osteogenic differentiation of AECs were investigated. AECs were isolated from amniotic membrane of human placenta by trypsin digestion and were induced by PEMF and/or osteo-induction medium. After 21 days we used real time RT-PCR and immunocytochemistry to study the expression of osteoblast markers. The signal transduction of osteogenesis was further investigated. The PEMF stimulation, or osteo-induction medium alone could induce osteogenic differentiation of AECs, as shown by expression of osteoblast specific genes and proteins including alkaline phosphatase and osteocalcin. Furthermore, a combination of PEMF and osteo-induction medium had synergy effects on osteogenic differentiation. In our study, the gene expression of BMP-2, Runx2, β-catenin, Nrf2, Keap1 and integrinβ1 were up-regulated in the osteogenic differentiation of AECs induced by PEMF and/or osteo-induction medium. Combined application of PEMF and osteo-induction medium is synergistic for the osteogenic differentiation of AECs. It might be a novel approach in the bone regenerative medicine.

Adolescent idiopathic scoliosis (AIS) is one of the most prevalent spinal abnormalities. Core stabilization exercise (CSE) has become a common approach in the treatment of AIS. However, the efficacy of CSE in AIS remains a subject of debate. To determine the efficacy of CSE in the patients with AIS in comparison with different intervention programs. A comprehensive search was conducted across PubMed, Embase, The Cochrane Library, Web of Science, Wan Fang, Wei Pu, and CNKI databases, encompassing literature from their inception through December 31st, 2024. Two independent reviewers screened the studies, with inter-rater agreement evaluated via kappa scores. Randomized control trials that focus on the efficacy and safety of CSE in AIS population were included in this systematic review. The risk of bias assessment was performed utilizing the National Institutes of Health Quality Assessment Tools (NIH-QAT). After quality assessments and information extraction, the meta-analysis was conducted with Review manager and the standard mean difference (SMD) was pooled among the measurement data derived from different studies. Cobb angle, angle of trunk rotation, apical vertebral rotation, Walter Reed Visual Assessment Scale, Posterior Trunk Symmetry Index, forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, SRS-22,, were focused as outcomes. A total of 10 studies involving 449 subjects were included in this systematic review. The average Cobb angle was 22.86° ± 8.79°, and the intervention duration varied from 8weeks to 6months. The kappa score was 0.93. Subgroup analyses were performed based on the different control groups, National Institutes of Health Quality Assessment Tools (NIH-QAT) results, and intervention durations. The results indicated that CSE could have greater effect sizes than the blank control group on Cobb angle (MD = -4.37, P < 0.05), angle of trunk rotation (MD = -1.07, P < 0.05), apical vertebral rotation (MD = -0.44, P < 0.05), quality of life as SRS-22 (MD = 0.22, P < 0.05). Notably, the efficacy of CSE appears to be weaker than that of the three-dimensional exercise group in terms of Cobb angle (MD = 3.95, P < 0.05), angle of trunk rotation (MD = 1.69, P < 0.05) and WASRS scores (MD = 0.89, P < 0.05). Other subgroup analyses yielded no statistically significant differences. The present study showed that core stabilization exercise may be beneficial for the patients with mild to moderate adolescent idiopathic scoliosis, albeit less effective than three-dimensional exercises following short-term follow-up. The evidence on the efficacy of CSE is limited due to heterogeneity, small sample sizes, and multiple comparisons. The clinical trials focusing on patient compliance and training quality with long-term follow-up are warranted. CRD 42022367714.

Myofascial Pain Syndrome (MPS) is a common pain disorder characterized by the presence of trigger points within the muscles or fascia. Low-intensity ultrasound therapy, as a noninvasive modality, has indeed found application in the management of MPS, but its efficacy for myofascial pain syndrome has still been controversial. The objective of this systematic review was to assess the safety and efficacy of low-intensity ultrasound therapy for MPS. We searched PubMed, Embase, PEDro, Web of Science, and CENTRAL for RCTs on ultrasound therapy in MPS patients. We included RCTs comparing ultrasound with other therapies or placebo-sham ultrasound. Clinical outcomes included pain scores and physical functional performance. Risk of bias and heterogeneity were assessed. Two authors of the review independently evaluated the risk of bias of each trial and extracted the data. This systematic review included sixteen RCTs involving a total of 1063 participants with MPS. None of the included studies reported adverse events. Comparing with sham or no treatment, the application of low-intensity ultrasound yielded additional benefits for pain (SMD [CI] = − 1.04 [− 1.72, − 0.36], P < 0.0003), with high heterogeneity (χ2 = 116.63, P < 0.00001, I2 = 91%). Patients receiving low-intensity ultrasound had improved on pressure pain threshold. Compared with other treatments, there were no differences in outcomes functional scores. The current study indicates that low-intensity ultrasound effectively reduces pain intensity in MPS patients. The heterogeneity regarding the parameters of ultrasound, including frequency, intensity, time was found to be high among the included studies. Each therapeutic modality works differently in various situations and may lead to multitudinous effects. The positive impact of low-intensity ultrasound on functional improvement needs to be further analyzed through more high-quality clinical trials with large sample sizes in the future. This study was registered on the following website: https://www.crd.york.ac.uk/PROSPERO/ . The PROSPERO registered ID is CRD42023472032.

Myofascial pain syndrome (MPS), a chronic musculoskeletal disorder characterized by myofascial trigger points (MTrPs). The objective is to explore the efficacy and safety of ultrasound-guided myofascial hydrodissection technique (UMHT) compared with trigger point injection of lidocaine (TPI) in the patients with MPS of upper trapezius. This randomized clinical trial was conducted at the rehabilitation medicine center of West China Hospital, Sichuan University, with 41 patients between May and October 2024. Patients were assigned to UMHT group (UMHT) or TPI group (1% lidocaine injection). Outcomes were measured at multiple time points using the Visual Analog Scale (VAS, primary), the short-form McGill pain questionnaire (SF-MPQ), and the neck disability index (NDI). Data were analyzed using SPSS v.29. The VAS scores was significantly decreased after receiving either UMHT (Effect sizes r = 0.716; p < 0.001) or TPI (Effect sizes r = 0.604; p < 0.001) during the 12-week follow-up period, while the SF-MPQ and the NDI showed similar positive results. There was no statistically significant difference between UMHT and TPI in pain reduction and function improvement (p > 0.05). No adverse events had been reported. Both UMHT and TPI demonstrate comparable efficacy and safety profiles in managing MPS of upper trapezius.