Objectives: Hardening the x-ray beam, tin prefiltration is established for imaging of high-contrast subjects in energy-integrating detector computed tomography (EID-CT). With this work, we aimed to investigate the dose-saving potential of spectral shaping via tin prefiltration in photon-counting detector CT (PCD-CT) of the temporal bone. Methods: Deploying dose-matched scan protocols with and without tin prefiltration on a PCD-CT and EID-CT system (low-/intermediate-/full-dose: 4.8/7.6–7.7/27.0–27.1 mGy), 12 ultra-high-resolution examinations were performed on each of 5 cadaveric heads. While 120 kVp was applied for standard imaging, the protocols with spectral shaping used the highest potential available with tin prefiltration (EID-CT: Sn 150 kVp, PCD-CT: Sn 140 kVp). Contrast-to-noise ratios and dose-saving potential by spectral shaping were computed for each scanner. Three radiologists independently assessed the image quality of each examination with the intraclass correlation coefficient being computed to measure interrater agreement. Results: Regardless of tin prefiltration, PCD-CT with low (171.2 ± 10.3 HU) and intermediate radiation dose (134.7 ± 4.5 HU) provided less image noise than full-dose EID-CT (177.0 ± 14.2 HU; P < 0.001). Targeting matched image noise to 120 kVp EID-CT, mean dose reduction of 79.3% ± 3.9% could be realized in 120 kVp PCD-CT. Subjective image quality of PCD-CT was better than of EID-CT on each dose level (P < 0.050). While no distinction was found between dose-matched PCD-CT with and without tin prefiltration (P ≥ 0.928), Sn 150 kVp EID-CT provided better image quality than 120 kVp EID-CT at high and intermediate dose levels (P > 0.050). The majority of low-dose EID-CT examinations were considered not diagnostic, whereas PCD-CT scans of the same dose level received satisfactory or better ratings. Interrater reliability was excellent (intraclass correlation coefficient 0.903). Conclusions: PCD-CT provides superior image quality and significant dose savings compared with EID-CT for ultra-high-resolution examinations of the temporal bone. Aiming for matched image noise, high-voltage scan protocols with tin prefiltration facilitate additional dose saving in EID-CT, whereas superior inherent denoising decreases the dose reduction potential of spectral shaping in PCD-CT.

Objectives: Detailed visualization of bone microarchitecture is essential for assessment of wrist fractures in computed tomography (CT). This study aims to evaluate the imaging performance of a CT system with clinical cadmium telluride-based photon-counting detector (PCD-CT) compared with a third-generation dual-source CT scanner with energy-integrating detector technology (EID-CT). Materials and Methods: Both CT systems were used for the examination of 8 cadaveric wrists with radiation dose equivalent scan protocols (low-/standard-/full-dose imaging: CTDI_vol = 1.50/5.80/8.67 mGy). All wrists were scanned with 2 different operating modes of the photon-counting CT (standard-resolution and ultra-high-resolution). After reformatting with comparable reconstruction parameters and convolution kernels, subjective evaluation of image quality was performed by 3 radiologists on a 7-point scale. For estimation of interrater reliability, we report the intraclass correlation coefficient (absolute agreement, 2-way random-effects model). Signal-to-noise and contrast-to-noise ratios were calculated to provide semiquantitative assessment of image quality. Results: Subjective image quality of standard-dose PCD-CT examinations in ultra-high-resolution mode was superior compared with full-dose PCD-CT in standard-resolution mode (P = 0.016) and full-dose EID-CT (P = 0.040). No difference was ascertained between low-dose PCD-CT in ultra-high-resolution mode and standard-dose scans with either PCD-CT in standard-resolution mode (P = 0.108) or EID-CT (P = 0.470). Observer evaluation of standard-resolution PCD-CT and EID-CT delivered similar results in full- and standard-dose scans (P = 0.248/0.509). Intraclass correlation coefficient was 0.876 (95% confidence interval, 0.744–0.925; P < 0.001), indicating good reliability. Between dose equivalent studies, signal-to-noise and contrast-to-noise ratios were substantially higher in photon-counting CT examinations (all P's < 0.001). Conclusions: Superior visualization of fine anatomy is feasible with the clinical photon-counting CT system in cadaveric wrist scans. The ultra-high-resolution scan mode suggests potential for considerable dose reduction over energy-integrating dual-source CT.

Objectives: In this study, we compared photon-counting detector computed tomography (PCD-CT) and energy-integrating detector computed tomography (EID-CT) for ultra-low-dose paranasal sinus examinations with employed tin prefiltration. The goal of our investigation was to define the most dose-effective scan protocols for diagnostic assessment of midface trauma, preoperative sinonasal anatomy, and acute rhinosinusitis. Materials and Methods: Five cadaveric heads were examined with the standard-resolution scan mode of both CT systems using a tube potential of 100 kV and tin prefiltration for 7 dose-equivalent scan protocols (CTDI_vol = 4.16–0.15 mGy) and 2 additional ultra-low-dose protocols exclusively feasible on the PCD-CT scanner (0.10 and 0.08 mGy). After applying comparable iterative reconstruction algorithms, image quality was subjectively assessed by 4 radiologists. The intraclass correlation coefficient was calculated to estimate the agreement among readers. Image noise was quantified in standardized regions of interest to establish an additional quantitative criterion of image quality. Results: The most dose-effective scan protocols for diagnostic imaging of midface trauma (PCD-CT: 1.24 mGy; EID-CT: 2.05 mGy), preoperative sinonasal anatomy (PCD-CT: 0.20 mGy; EID-CT: 0.40 mGy), and acute rhinosinusitis (PCD-CT: 0.08 mGy; EID-CT: 0.15 mGy) required less radiation exposure on the PCD-CT system (P < 0.050). Despite higher image noise, ultra-low-dose PCD-CT studies (0.08 and 0.10 mGy) were considered suitable for inflammation-focused imaging, offering lower-dose penalties than EID-CT studies. Interobserver reliability for subjective image quality was excellent (intraclass correlation coefficient, 0.90; 95% confidence interval, 0.88–0.93; P < 0.001). Conclusions: In paranasal sinus imaging with tin prefiltration, the PCD-CT allowed for superior image quality compared with high-end EID-CT. Assessment of paranasal sinuses with an ultra-low radiation exposure of 0.08 mGy was deemed adequate, suggesting substantial dose reduction potential for clinical routine, for example, in the diagnostic workup of patients with rhinosinusitis.

Patients with Congenital heart disease (CHD) require repetitive imaging of the pulmonary vasculature throughout their life. In this study, we compared a novel Compressed SENSE accelerated (factor 9) electrocardiogram (ECG)- and respiratory-triggered 3D modified Relaxation-Enhanced Angiography without Contrast and Triggering (modified REACT-non-contrast-enhanced magnetic resonance angiography (modified REACT-non-CE-MRA)) with standard non-ECG-triggered time-resolved 4D CE-MRA for imaging of the pulmonary arteries and veins in patients with CHD. This retrospective analysis of 25 patients (June 2018–April 2019) with known or suspected CHD was independently conducted by two radiologists executing measurements on modified REACT-non-CE-MRA and 4D CE-MRA on seven dedicated points (inner edge): Main pulmonary artery (MPA), right and left pulmonary artery, right superior and inferior pulmonary vein, left superior (LSPV) and inferior pulmonary vein. Image quality for arteries and veins was evaluated on a four-point scale in consensus. Twenty-three of the 25 included patients presented a CHD. There was a high interobserver agreement for both methods of imaging at the pulmonary arteries (ICC ≥ 0.96); at the pulmonary veins, modified REACT-non-CE-MRA showed a slightly higher agreement, pronounced at LSPV (ICC 0.946 vs. 0.895). Measurements in 4D CE-MRA showed higher diameter values compared to modified REACT-non-CE-MRA, at the pulmonary arteries reaching significant difference (e.g. MPA: mean 0.408 mm, p = 0.002). Modified REACT-non-CE-MRA (average acquisition time 07:01 ± 02:44 min) showed significant better image quality than 4D CE-MRA at the pulmonary arteries (3.84 vs. 3.32, p < 0.001) and veins (3.32 vs. 2.72, p = 0.015). Compressed SENSE accelerated (factor 9) ECG- and respiratory-triggered 3D modified REACT-non-CE-MRA allows for reliable and fast imaging of the pulmonary arteries and veins with higher image quality and slightly higher interobserver agreement than 4D CE-MRA without contrast agent and associated disadvantages. Therefore, it represents a clinically suitable technique for patients requiring repetitive imaging of the pulmonary vasculature, e.g. patients with CHD.

Objectives: The aim of this study was to investigate potential benefits of ultra-high resolution (UHR) over standard resolution scan mode in ultra-low dose photon-counting detector CT (PCD-CT) of the lung. Materials and Methods: Six cadaveric specimens were examined with 5 dose settings using tin prefiltration, each in UHR (120 × 0.2 mm) and standard mode (144 × 0.4 mm), on a first-generation PCD-CT scanner. Image quality was evaluated quantitatively by noise comparisons in the trachea and both main bronchi. In addition, 16 readers (14 radiologists and 2 internal medicine physicians) independently completed a browser-based pairwise forced-choice comparison task for assessment of subjective image quality. The Kendall rank coefficient (W) was calculated to assess interrater agreement, and Pearson's correlation coefficient (r) was used to analyze the relationship between noise measurements and image quality rankings. Results: Across all dose levels, image noise in UHR mode was lower than in standard mode for scan protocols matched by CTDI_vol (P < 0.001). UHR examinations exhibited noise levels comparable to the next higher dose setting in standard mode (P ≥ 0.275). Subjective ranking of protocols based on 5760 pairwise tests showed high interrater agreement (W = 0.99; P ≤ 0.001) with UHR images being preferred by readers in the majority of comparisons. Irrespective of scan mode, a substantial indirect correlation was observed between image noise and subjective image quality ranking (r = −0.97; P ≤ 0.001). Conclusions: In PCD-CT of the lung, UHR scan mode reduces image noise considerably over standard resolution acquisition. Originating from the smaller detector element size in fan direction, the small pixel effect allows for superior image quality in ultra-low dose examinations with considerable potential for radiation dose reduction.