Intelligence in Industry 4.0 has led to the development of smart buildings with various control systems for data collection, efficient optimization, and fault detection and diagnosis (FDD). However, buildings, especially with regard to heating, ventilation, and air conditioning (HVAC) systems, are responsible for significant global energy consumption. Digital Twin (DT) technology offers a sustainable solution for facility management. This study comprehensively reviews DT performance evaluation in building life cycle and predictive maintenance. 200 relevant papers were selected using a systematic methodology from Scopus, Web of Science, and Google Scholar, and various FDD methods were reviewed to identify their advantages and limitations. In conclusion, data-driven methods are gaining popularity due to their ability to handle large amounts of data and improve accuracy, flexibility, and adaptability. Unsupervised and semi-supervised learning as data-driven methods are important for FDD in building operations, such as with HVAC systems, as they can handle unlabeled data and identify complex patterns and anomalies. Future studies should focus on developing interpretable models to understand how the models made their predictions. Hybrid methods that combine different approaches show promise as reliable methods for further research. Additionally, deep learning methods can analyze large and complex datasets, indicating a promising area for further investigation.

The growing complexity of modern building systems requires advanced monitoring frameworks to improve fault detection, energy efficiency, and operational resilience. Digital Twin (DT) technology, which integrates real-time data with virtual models of physical systems, has emerged as a promising enabler for predictive diagnostics. Despite growing interest, key challenges remain, including the neglect of short- and long-term forecasting across different scenarios, insufficiently robust data preparation, and the rare validation of models on multi-zone buildings over extended test periods. To address these gaps, this study presents a comprehensive DT-enabled framework for predictive monitoring and anomaly detection, validated in a multi-zone educational building in Rhode Island, USA, using a full year of operational data for validation. The proposed framework integrates a robust data processing pipeline and a comparative analysis of machine learning models, including LSTM, RNN, GRU, ANN, XGBoost, and RF, to forecast short-term (1 h) and long-term (24 h) indoor temperature variations. The LSTM model consistently outperformed other methods, achieving R² > 0.98 and RMSE < 0.55 °C for all tested rooms. For real-time anomaly detection, we applied the hybrid LSTM–Interquartile Range (IQR) method on one-step-ahead residuals, which successfully identified anomalous deviations from expected patterns. The model’s predictions remained within a ±1 °C error margin for over 90% of the test data, providing reliable forecasting up to 16 h ahead. This study contributes a validated, generalizable DT methodology that addresses key research gaps, offering practical tools for predictive maintenance and operational optimization in complex building environments.