Background. Legg–Calvé–Perthes (LCPD) disease is a complex condition affecting the femoral head’s epiphysis in children. It occurs with a prevalence ranging from 0.4 to 29.0 cases per 100,000 children under the age of 15. It involves various factors, including genes associated with coagulation and fibrinolysis, pro-inflammatory factors, and vasoactive substances. Methods. We investigated the relationship between genetic mutations associated with coagulation and vascular disorders and the occurrence of LCPD in Polish patients. We performed a study involving 25 patients with LCPD and 100 healthy controls. All subjects were genotyped for eNOS4, Factor V Leiden, prothrombin, tPA25, and MTHFR polymorphism. Results. The analysis revealed that the frequencies of eNOS4 genotypes were significantly different in LCPD patients than in the control group (p = 0.018). The frequencies of 4a allele were significantly higher in patients with LCPD than in the healthy population (26% vs. 9%, p = 0.0012). There were no significant differences in genotype and allele frequencies for Factor V Leiden, prothrombin tPA 25, and MTHFR gene polymorphisms between patients with LCPD and the controls. Conclusions. Genotype and allele frequencies of eNOS4 were significantly higher in patients with LCPD. These findings suggest a potential association between the eNOS gene polymorphism and an increased risk of developing LCPD.

Introduction and objective: Patella dislocation represents 3.3% of all knee injuries often leading to persistent instability. Medial patello-femoral ligament(MPFL) reconstruction is the standard method of treatment in the patellar instability. Rehabilitation after MPFL-R is a long and demanding...

Introduction: Bupropion is currently mainly used as an atypical antidepressant due to its psychotropic effects. In addition, it shows high potential in reducing withdrawal cravings in addicts, which is also used in the treatment of nicotinism. However, studies in recent years have shown that it may also be useful in other conditions.Aim of the study: Our aim was to review the known usage of bupropion in the fields of psychiatry, neurology and internal medicine, and to identify potential directions for further research. Methods and materials: We reviewed the literature available in the PubMed database, using the key words: "bupropion"; "depression"; "smoking cessation"; "obesity"; "ADHD".Results: Bupropion- an antidepressant drug belonging to the group of selective norepinephrine and dopamine reuptake inhibitors. Bupropion is approved by the FDA(Food and Drug Administration) for the treatment of depression, seasonal affective disorder and nicotinism. The literature shows that it is also effective in off-label indications - treatment of antidepressant-induced sexual dysfunction, attention deficit hyperactivity disorder (ADHD), depression in bipolar disorder, obesity, neuropathic pain and cancer-related fatigue syndrome.Conclusion: Due to the specific effects of bupropion, there are many more usage for the drug than the primary indications for which it is usually used. The usage of the drug described in the literature require additional studies on a larger group of patients.

Introduction: There are 425 million adults with diabetes worldwide, 10% of whom have type 1 diabetes. The treatment of choice in this group of patients is insulin delivery. In order to avoid disease-related metabolic disorders, insulin therapy should be planned so that their risk is minimized. This often involves multiple subcutaneous deliveries throughout the day. In order to improve patient satisfaction and comfort, , "smart pumps" have been developed. OmniPod® is the first commercially available pump of this type. Aim of the study: The purpose of our work was to present an innovative form of treatment for type 1 diabetes, to demonstrate the advantages, disadvantages and results of treatment using it. Methods and materials: A literature review was conducted in the PubMed database, using the key words: "diabetes type 1"; "diabetes mellitus"; "OmniPod®"; "insulin"; Results: OmniPod® improves glycemic control and glycated hemoglobin (HbA1c) values over traditional therapies. The algorithm used in the pump ensures normal glycemic ranges throughout the day, without the risk of prolonged episodes of hypo- and hyperglycemia. It improves the quality of life (QOL) index thanks to, among other things, water resistance, lack of difficulties during sleep in contrast to conventional insulin pumps. Conclusion: OmniPod® significantly improves users' glycemic and HbA1c control. It allows users to forgo conventional insulin pumps or intensive insulin therapy by raising QOL and increasing patients' sense of proper disease control. Further research should be inclined to evaluate the utility of OmniPod® in other types of diabetes, as well as on the application of the technology in other disease entities.

Introduction: Every year, more and more people are using manicure and pedicure services performed with UV lamps. As public awareness of the harmfulness of prolonged exposure to UV light increases, there are doubts about the safety of frequent treatments using it. Aim of the study: The aim of the study was to find out whether regular use of UV nail lamps is safe and to educate patients about the prevention of potential cancer. Methods and materials: A literature review was performed in the PubMed database using the keywords: UV; nail lamp; skin cancer; risk. Resulsts: Certain clinical cases indicate that long-term, regular exposure to UVA radiation from nail lamps can increase the risk of squamous cell carcinoma of the skin and actinic keratosis, but other risk factors may overlap. According to a statement by the U.S. Food and Drug Administration (FDA), the use of these devices is safe. Thus, the results of the studies appear to be inconclusive. Both the researchers who prove the safety of lamp use and those who question it unanimously recommend the use of prophylaxis and educating patients about it. Conclusions: The use of UV nail lamps is not associated with significant risks. Single clinical cases describing the development of squamous cell carcinoma of the skin and actinic keratosis appear to be anecdotal. As the low probability of cancer formation is still taken into account, it is worth taking the recommended precautions: using creams with a broad-spectrum UV filter 20 minutes before exposure or manicure gloves. Using LED nail lamps instead of classic UV lamps will also be beneficial. The topic is a developing one and will require more research attention.

This technical note describes a practical, anatomy‐based medial patellofemoral ligament reconstruction technique emphasizing individualized, dynamic graft tensioning and independent adjustment of patellar graft arms. By prioritizing femoral fixation first, guided by precise, dynamic anatomical landmarks and arthroscopic verification, the graft achieves optimal isometry and stability throughout the range of motion. The method utilizes a gracilis tendon “V”‐shaped graft configuration with oblique patellar tunnels, ensuring symmetrical, independent tensioning of both graft arms. Additionally, intraoperative graft tension adjustments facilitate dynamic patellar realignment within the trochlear groove, accommodating anatomical variability and trochlear shape differences. This approach aims to reduce complications, enhance patellar tracking, and produce consistent outcomes, especially in cases of severe trochlear dysplasia with variable bony anatomy.