Among the main arboviruses affecting public health in tropical regions are dengue, zika, and chikungunya, transmitted mainly by mosquitoes of the Aedes genus, especially Aedes aegypti. In recent years, outbreaks have posed major challenges to global health, highlighting the need for integrated and innovative strategies for their control and prevention. Prevention strategies include the elimination of vectors and avoiding mosquito bites; this can be achieved through the use of bioinsecticides and repellents based on plant phytochemicals, as they offer sustainable, ecological, and low-cost alternatives. Mexico has a variety of plants from which both extracts and essential oils have been obtained which have demonstrated significant efficacy in repelling and/or killing insect vectors. This review examines the current knowledge on plant species found in Mexico which are promising options concerning synthetic compounds in terms of their repellent and insecticidal properties against mosquitoes of the genus Aedes and that are friendly to the environment and health.
Banana is the most cultivated fruit plant in the world. It is produced in Latin America, Asia and Africa. India and China are the world’s largest banana producers, with almost 41% of the world’s production. This fruit reaches a total world production of 158.3 million tons per year. However, during their production cycle, the banana agroindustry produces large volumes of solid waste derived from overripe fruit. It contributes between 8–20 percent of the waste (around 100 kg of banana waste for every ton of banana produced). Therefore, the use of overripe banana waste represents a huge opportunity for bioenergy production. This work demonstrates that banana waste can be further used for power generation using a microbial fuel cell (MFC) coupled with anaerobic digestion (AD). First, the maximum methane production (MMP), methane production rate (MPR) and biochemical methane potential (BMP) were measured using an anaerobic batch bioreactor for 64 days of monitoring. Finally, the digestate generated from AD was used in the MFC to determine the polarization curve, maximum voltage, maximum power density (MPD), resistance and current. As a result, the AD generated an MMP of 320.3 mL, BMP of 373.3 mLCH4/gVS and MPR of 18.6 mLCH4/Lb⋅day. The MFC generated 286 mV (maximum voltage), 41.3 mW/m2 (MPD), 580.99 Ω (resistance) and 0.0002867 A (current). Both processes together produced a total bioenergy of 13.38 kJ/gVS. This coupled system showed a suitable and promising use of banana waste for ecofriendly bioenergy generation. Therefore, this feedstock could be taken advantage of for generating sustainable processes and developing a circular economy in the banana agroindustry.
Overweight and obesity are major public health issues worldwide, including in Mexico, particularly among adolescents. This study aimed to analyze the associations between nutritional status and impaired executive function (EF) in Mexican adolescents. A case–control study was conducted with 98 male and female adolescents, categorized into normal weight and overweight/obese groups based on body mass index. EF was assessed using the BANFE-2 test. The prevalence of overweight and obesity was 54.3%. The EF assessment revealed that 82.45% of the overweight/obese group exhibited mild-to-severe impairment, compared to only 36.58% in the normal weight group (X2 = 21.69, p < 0.0001). In the inhibitory control assessment, adolescents with overweight and obesity performed worse than their normal-weight counterparts. Specifically, females with overweight/obesity scored lower than females with normal weight on the risk–benefit processing test. The risk of severe EF impairment significantly increased with the presence of overweight/obesity (OR = 7.8, p < 0.0001). These findings indicate that EF, particularly inhibitory control and risk–benefit processing, is impaired in adolescents with overweight or obesity.
Fusarium are considered as the major plant pathogen fungi, that cause the majority of soil-borne diseases to more than 100 plant species in the world, including maize. Thus, there are emerging demands of biocontrol reagents, and Crotalaria longirostrata showed fungicidal activity. The C. longirostrata branch extract was phytochemically characterized and evaluated for efficacy for the control of Fusarium wilt in maize. The application of the extract reduced the percentage of disease incidence significantly caused by Fusarium verticillioides from 70.4% to 40.12% as compared to non-treated plants, and evenly the disease severity was reduced from 40.15% to 29.46%. The phytochemical components of the extract were cinnamic acids (caffeic acid and ferulic acid) and phenolic acid (gallic acid). Furthermore, multiple structures were detected through mass spectrometry such as: phenols, alkaloids, esters, terpene, ketones, and amides. The bioautography assay showed that to separate the compounds of C. longirostrata branch extract causes it’s the loss of fungicidal activity. This is due to the synergy or additive interactions of secondary metabolites present in the raw extract. Our results suggest that the application of C. longirostrata branch extract is a promising strategy to be applied to the soil as a preventive treatment.
Pain represents one of the leading causes of suffering and disability worldwide. Currently available drugs cannot treat all types of pain and may have adverse effects. Hence, the use of pharmacological combinations is an alternative treatment strategy. Therefore, this study aimed to evaluate the combination of resveratrol and ketorolac through isobolographic analysis. CD1 mice were used to study the antinociceptive effect of this combination using the formalin test and the study was divided into two phases. In the first phase, four individual doses of each drug were evaluated, totaling eight testing groups. From these data, the median effective doses (ED50) of each drug were calculated. In the second phase, four testing groups were used to evaluate the combination of sub-doses of both drugs and obtain the experimental ED50. To evaluate gastric damage, five groups were employed, including indomethacin, vehicle, resveratrol, ketorolac, and combined resveratrol and ketorolac groups. Stomach samples from the mice were taken after 5 h of treatment, and the area of the ulcers was determined. Resveratrol plus ketorolac elicited a reduction in nociceptive behavior during both phases of the formalin test, and isobologram analysis revealed that the theoretical and experimental ED50 values of resveratrol and ketorolac did not differ significantly, implying an additive interaction between the drugs. Additionally, the drug combination did not generate gastric ulcers, thus enhancing the desired effects without increasing the adverse effects. Consequently, these findings substantiate the efficacy of the resveratrol and ketorolac combination in the formalin test, thereby highlighting its potential as a viable alternative for alleviating pain.
The Enterobacteriaceae family poses health risks due to its role in gastrointestinal diseases like acute diarrhea. With rising antibiotic resistance, plants offer promising antibacterial compounds with low toxicity. This study evaluated the antibacterial activity, minimum inhibitory concentration (MIC), and toxicity of ethanolic (EE) and aqueous (AE) extracts from five Mexican medicinal plants traditionally used in Chiapas for treating acute diarrheal diseases (ADD). Antibacterial activity was assessed using disk diffusion assays and MIC determined by macrodilution. Toxicity tests were performed using Artemia salina. As a result, EE extracts exhibited higher antibacterial activity than AE extracts. Byrsonima crassifolia effectively inhibited Salmonella enteritidis (78.26%, MIC 50 mg/mL) and Shigella dysenteriae (76.19%, MIC 25 mg/mL). Solanum torvum showed efficacy against Escherichia coli (55.55%, MIC 12.5 mg/mL) and Salmonella enteritidis (73.91%, MIC 25 mg/mL). Euphorbia maculata inhibited Shigella dysenteriae (104.76%, MIC 25 mg/mL), while Guazuma ulmifolia and Bursera simaruba exhibited no antibacterial effects. All extracts were non-toxic (LD50 > 1000 μg/mL), indicating potential as natural alternatives for ADD treatment.