Brain map of touch sensation: The brain's somatosensory cortex contains a topographical map that reflects touch sensation inputs. During embryonic development, axons from the midbrain thalamus build columnar connections to the cortex in the absence of sensory input. Working in mice, Antón-Bolaños et al. found that these thalamocortical connections are responsible for organizing the somatosensory cortex (see the Perspective by Tiriac and Feller). Organization of the map in the cortex depends on spontaneous calcium waves in the embryonic thalamus. Thus, the somatosensory map is sketched out before actual sensory input begins to refine the details. Science , this issue p. 987 ; see also p. 933

A new intervention model for promoting healthy ageing grounded on integrated value-based care was developed and tested in the city of Valencia (Spain). Its implementation raised relevant barriers for older adults in their access to health, health promotion, and health self-management linked with their health and digital literacy. This new intervention model included several aspects. On the one hand, researchers together with older adults and their informal caregivers participating in the study, designed personalized care plans, based on older adults’ specific needs, to be implemented with the support of a digital solution. On the other hand, researchers and health and social professionals implemented a series of workshops in different locations of the city to encourage a sense of community among participants, reinforcing their trust in the new care model and increasing their adherence. Social activities were at the core of the workshops to understand older people’s interaction with the health and social services provided in the neighborhood. Qualitative and quantitative methods were combined to extract information from older participants on how to engage them as active actors of their health and understand their values and preferences. In the present manuscript, we focus on the qualitative results, which show that after a post-pandemic situation, they were more concerned about social isolation and desired face-to-face contact with their professional care team; however, feelings of loneliness and/or sadness were not considered among the reasons to visit health professionals. Some of the conclusions revealed that the use of technology as a supportive tool is well received but with a stress on its role as “supportive”, and not replacing the close contact with healthcare professionals. Professionals recognized the benefits of this new approach but required more time and incentives to dedicate the effort needed. The main aim of this study was to present these barriers related to health access, health promotion, and health self-management, as well as the actions developed to face them.

A new intervention model for promoting healthy ageing grounded on integrated value-based care was developed and tested in the city of Valencia (Spain). Its implementation raised relevant barriers for older adults in their access to health, health promotion, and health self-management linked with their health and digital literacy. This new intervention model included several aspects. On the one hand, researchers together with older adults and their informal caregivers participating in the study, designed personalised care plans, based on older adults’ specific needs, to be implemented with the support of a digital solution. On the other hand, researchers and health and social professionals implemented a series of six workshops in different locations of the city to encourage the sense of community among participants, reinforcing their trust in the new care model and increasing their adherence. Social activities were at the core of the workshops to understand older people’s interaction with the health and social services provided in the neighbourhood. Qualitative and quantitative methods were combined to extract information from older participants on how to engage them as active actors of their own health and understanding their values and preferences. Qualitative results show that after a post-pandemic situation, they were more concerned about social isolation and desired face-to-face contact with their professional care team; however, feelings of loneliness and/or sadness were not considered amongst the reasons to visit health professionals. Some of the conclusions reveal that the use of technology as a supportive tool is well received but with a stress on its role as “supportive”, and not replacing the close contact with healthcare professionals. Professionals recognised the benefits of this new approach but required more time and incentives to dedicate the effort needed.

Identifying tobacco smoke exposure in indoor environments is critical for public health, especially in vulnerable populations. In this study, we developed and validated a machine learning model to detect smoking households based on indoor air quality (IAQ) data collected using low-cost sensors. A dataset of 129 homes in Spain and Austria was analyzed, with variables including PM_2.5, PM₁, CO₂, temperature, humidity, and total VOCs. The final model, based on the XGBoost algorithm, achieved near-perfect household-level classification (100% accuracy in the test set and AUC = 0.96 in external validation). Analysis of PM_2.5 temporal profiles in representative households helped interpret model performance and highlighted cases where model predictions revealed inconsistencies in self-reported smoking status. These findings support the use of sensor-based approaches for behavioral inference and exposure assessment in residential settings. The proposed method could be extended to other indoor pollution sources and may contribute to risk communication, health-oriented interventions, and policy development, provided that ethical principles such as transparency and informed consent are upheld.

Background/Objectives: In the framework of the ValueCare project (funded by EC, ref 875215), the Valencia pilot site assessed the comprehensive health of 240 older people with frailty. ValueCare aims to deliver personalised integrated health and social care and better outcomes for older people. Methods: For the health evaluation, a comprehensive approach was adopted, based on validated questionnaires that address not only mental and physical health but also other key dimensions in older people’s well-being, namely unwanted loneliness and nutrition. Results: This study provides an overview of the overall health status of 60-year-old people from March to December 2022 in the city of Valencia, allowing for a comparison between national and European health indicators. Conclusions: Older people in the city of Valencia reported good health, quality of life, independency, nutrition and social wellbeing, with some differences between gender.