Magnetocardiography is a contactless imaging modality for electric current propagation in the cardiovascular system. Although conventional sensors provide sufficiently high sensitivity, their spatial resolution is limited to a centimetre-scale, which is inadequate for revealing the intra-cardiac electrodynamics such as rotational waves associated with ventricular arrhythmias. Here, we demonstrate invasive magnetocardiography of living rats at a millimetre-scale using a quantum sensor based on nitrogen-vacancy centres in diamond. The acquired magnetic images indicate that the cardiac signal source is well explained by vertically distributed current dipoles, pointing from the right atrium base via the Purkinje fibre bundle to the left ventricular apex. We also find that this observation is consistent with and complementary to an alternative picture of electric current density distribution calculated with a stream function method. Our technique will enable the study of the origin and progression of various cardiac arrhythmias, including flutter, fibrillation, and tachycardia.

The newly developed radioisotope-free technique based on magnetic nanoparticle detection using a magnetic probe is a promising method for sentinel lymph node biopsy. In this study, a novel handheld magnetic probe with a permanent magnet and magnetic sensor is developed to detect the sentinel lymph nodes in breast cancer patients. An outstanding feature of the probe is the precise positioning of the sensor at the magnetic null point of the magnet, leading to highly sensitive measurements unaffected by the strong ambient magnetic fields of the magnet. Numerical and experimental results show that the longitudinal detection length is approximately 10 mm, for 140 μg of iron. Clinical tests were performed, for the first time, using magnetic and blue dye tracers—without radioisotopes—in breast cancer patients to demonstrate the performance of the probe. The nodes were identified through transcutaneous and ex-vivo measurements, and the iron accumulation in the nodes was quantitatively revealed. These results show that the handheld magnetic probe is useful in sentinel lymph node biopsy and that magnetic techniques are widely being accepted as future standard methods in medical institutions lacking nuclear medicine facilities.

Significance: We have developed an ultraflexible and MRI-compatible optogenetic stimulator using organic light emitting diodes (OLEDs), which activate channelrhodopsin-2–expressing neurons in transgenic animals. The OLEDs can be conformably attached to soft neuronal tissues, such as peripheral nerves or brain, and the superior mechanical flexibility significantly reduces mechanical damages to the tissues. They are also compatible with neuroimaging techniques such as MRI, while allowing investigation of the evoked activities induced by optical stimulations without artifact effects. Finally, we have successfully demonstrated the optical stimulation of the peripheral nerves and the brains of rats and visualized the evoked neuronal activities induced by optical stimulations using the functional MRI.

We present a sensitive diamond quantum sensor with a magnetic field sensitivity of $9.4\pm 0.1\mathrm{pT}/\sqrt{\mathrm{Hz}}$ in a near-dc frequency range of 5 to 100 Hz. This sensor is based on the continuous-wave optically detected magnetic resonance of an ensemble of nitrogen-vacancy centers along the [111] direction in a diamond (111) single crystal. The long $T_2^{\ast }\sim 2\text{μ}\mathrm{s}$ in our diamond and the reduced intensity noise in laser-induced fluorescence result in remarkable sensitivity among diamond quantum sensors. Based on an Allan-deviation analysis, we demonstrate that a subpicotesla field of 0.3 pT is detectable by interrogating the magnetic field for a few thousand seconds. The sensor head is compatible with various practical applications and allows a minimum measurement distance of about 1 mm from the sensing region. The proposed sensor facilitates the practical application of diamond quantum sensors. The sensitivity presented is realized without a magnetic flux concentrator, so that a sensitivity of tens of $\mathrm{fT}/\sqrt{\mathrm{Hz}}$ can be achievable by using a flux concentrator.

This article reviews the evolution and recent developments of transcranial magnetic brain stimulation using figure-eight coils to stimulate localized areas in the human brain. Geometric variations of figure-eight coils and their characteristics are reviewed and discussed for applications in neuroscience and medicine. Recent topics of figure-eight coils, such as focality of figure-eight coils, tradeoff between depth and focality, and approaches for extending depth, are discussed.

New laparoscopic sentinel lymph node navigation using a dedicated magnetic probe and magnetic nanoparticle tracer for gastric cancer patients allows minimally invasive surgeries. By identifying the sentinel lymph nodes containing magnetic nanoparticles, patients can avoid excessive lymph node extraction without nuclear facilities and radiation exposure. This paper describes the development of the laparoscopic magnetic probe, ACDC-probe, for laparoscopic sentinel lymph node identification utilizing the nonlinear response of the magnetic nanoparticles magnetized by an alternating magnetic field with a static magnetic field. For highly sensitive detection, the ratio of static to alternating magnetic fields was optimized to approximately 5. The longitudinal detection length was approximately 10 mm for 140 μg of iron, and the detectable amount of iron was approximately 280 ng at a distance of 1 mm. To demonstrate the feasibility of laparoscopic detection using the ACDC-probe and magnetic tracers, an experiment was performed on a wild swine. The gastric sentinel lymph node was clearly identified during laparoscopic navigation. These results suggest that the newly developed ACDC-probe is useful for laparoscopic sentinel lymph node detection and this magnetic technique appears to be a promising method for future sentinel lymph node navigation of gastric cancer patients.