Background: Analyzing trends and patterns of vaccination during COVID-19 pandemic is important to understand how current policies are working. Evidence regarding the general population is already available, but hard-to-reach populations as migrants or minorities, but also people suffering from a Substance Use Disorder (SUD), have not been fully explored. To understand the extent of vaccine adherence and evaluate associated factors in this population subgroup, we conducted a cross-sectional study in collaboration with Villa Marini Foundation, national agency of the Italian Red Cross for pathological addictions. Methods: We developed a questionnaire regarding COVID-19 vaccination, adherence to prevention measures, concerns about COVID-19 and questions relating to drug use that we administered to each participant. Only people aged over 18 with a diagnosis of SUD were included in the study. A multivariable logistic regression model was built to identify the predictors associated with anti-SARS-CoV-2 vaccination, estimating adjusted odds ratios (aOR) and 95% confidence intervals (CIs). Results: We recruited 200 participants between December 2021 and January 2022. Most respondents were male (84.5%), Italian (72%), aged 44 years on average. A total of 40 patients (20%) reported they haven't received any dose of COVID-19 vaccine; the most common motivations were lack of trust in the vaccine and fear of side effects. At multivariable analysis, the use of heroin appears to be negatively associated with vaccination acceptance (aOR=0.31 CI 95%: 0.11-0.81) as well as not being Italian (aOR=0.27 CI 95%: 0.12-0.63). Conclusions: The vaccination rate in our sample was consistent with the one of the general Italian population in the same period, whereas the reasons behind the lower adherence to vaccination in the heroin group need to be further investigated. It’s also important to reduce possible bureaucratic obstacles that could explain the lower number of vaccinated foreign citizens. Key messages: • People with Substance Use Disorder are a fragile and often overlooked population that needs to be considered during Public Health intervention and vaccination campaigns. • The access to vaccination for foreigners should be made more simple and easier to increase accessibility and participation.

Adherence to vaccination recommendations is a challenge for national immunization programs. We quantified adherence to COVID-19 vaccination recommendations in people with substance use disorders (SUDs) attending an outpatient addiction center in Rome, Italy; we investigated the determinants of adherence, and also analyzed patient risk perception and compliance with preventive measures. A multivariable logistic regression model identified predictors of adherence to vaccination recommendations, with statistical validity tested by estimating adjusted odds ratios (aORs) and 95% confidence intervals (CIs). From December 2021 to January 2022, 200 SUD patients completed a questionnaire, 80% of whom reported being vaccinated against SARS-CoV-2 (minimum one dose). Negative predictors of vaccine uptake included being non-Italian (aOR: 0.36, 95% CI: 0.13–0.97), having coexisting comorbidities (aOR: 0.35, 95% CI: 0.13–0.95), and previous use of heroin (aOR: 0.24, 95% CI: 0.08–0.71). No difference was found for cocaine use, demographic characteristics, previous COVID-19 infection, methadone therapy, or compliance with preventive measures. Major reasons for non-adherence to vaccination recommendations were fear of side effects, insufficient recognition of the importance of vaccination, bureaucratic issues, and lack of trust in the authorities. Given their vulnerability, additional efforts are needed to facilitate access to vaccination for people with SUDs, and to limit disinformation around vaccines..

Background: In occasion of WNTD (World No Tobacco Day) 2021, the team of UNITAB (Unit of Tobaccology of Sapienza University of Rome) ran a survey among university students to determine their smoking habits and the grade of agreement to an increase of tobacco taxation. Methods: The survey is...