Auxetic cellular solids in the forms of honeycombs under blast load have great potential in a diverse range of applications, including core material in sandwich plates composite components. Based on Reddy’s first-order shear deformation plate theory, this paper presents an analysis of the nonlinear dynamic response and vibration of sandwich plates with negative Poisson’s ratio in auxetic honeycombes on elastic foundations subjected to blast and mechanical loads. A three-layer sandwich plate is considered discretized in the thickness direction by using analytical methods (stress function method, approximate solution), Galerkin method, and fourth-order Runge-Kutta method. The results show the effects of geometrical parameters, material properties, mechanical and elastic foundations on the nonlinear dynamic response, and vibration of sandwich plates.