Prostate cancer (PCa) remains a significant global health concern, being a major cause of cancer morbidity and mortality worldwide. Furthermore, profound understanding of the disease is needed. Prostate inflammation caused by external or genetic factors is a central player in prostate carcinogenesis. However, the mechanisms underlying inflammation-driven PCa remain poorly understood. This review dissects the diagnosis methods for PCa and the pathophysiological mechanisms underlying the disease, clarifying the dynamic interplay between inflammation and leukocytes in promoting tumour development and spread. It provides updates on recent advances in elucidating and treating prostate carcinogenesis, and opens new insights for the use of bioactive compounds in PCa. Polyphenols, with their noteworthy antioxidant and anti-inflammatory properties, along with their synergistic potential when combined with conventional treatments, offer promising prospects for innovative therapeutic strategies. Evidence from the use of polyphenols and polyphenol-based nanoparticles in PCa revealed their positive effects in controlling tumour growth, proliferation, and metastasis. By consolidating the diverse features of PCa research, this review aims to contribute to increased understanding of the disease and stimulate further research into the role of polyphenols and polyphenol-based nanoparticles in its management.

Water scarcity has become an increasingly critical global issue, affecting various sectors, including industrial, domestic, and particularly agriculture. Agriculture, as the largest consumer of water due to its substantial water requirements for food production, faces significant challenges, which are expected to intensify with the growth of the global population. As a result, many countries have begun to explore innovative solutions to address this pressing problem, one of which is the reuse of wastewater for irrigation purposes. This approach has gained particular attention in viticulture, where water consumption is high, and the need for sustainable practices is paramount. This paper delves into the issue of water scarcity, focusing specifically on the winemaking sector. It reviews several studies investigating the potential of wastewater reuse for irrigating vineyards, highlighting both the promising benefits and the challenges associated with this practice. The findings suggest that using treated wastewater for irrigation in viticulture offers a viable solution to mitigate water shortages, particularly in regions facing severe droughts or limited freshwater resources. However, the successful implementation of this approach requires careful monitoring and management of several factors, including soil quality, plant health, fruit development, and the final wine product. Ensuring the safety and quality of the wine, as well as safeguarding consumer health, necessitates rigorous oversight to prevent any negative impacts from the use of reclaimed water.

The winery industry generates significant amounts of organic waste, such as pruning firewood, stems, and wine lees, which can cause environmental issues and affect the economic sustainability and competitiveness of the industry. Given the known antioxidant and antimicrobial properties of phenolic compounds, we analyzed these by-products to quantify their phenolic composition and evaluate the effectiveness of pruning firewood and stem extracts from six autochthonous varieties of the Dão Region in inhibiting the growth of bacteria from diabetic foot wounds isolated from hospital patients. The study employed colorimetric methods to measure total phenols, ortho-diphenols, and flavonoids in the phenolic composition. The ABTS, DPPH, and FRAP methods were applied to assess the antioxidant capacity, and the disk diffusion method was applied to determine the antimicrobial activity of Gram-positive and Gram-negative bacteria. The results showed that Jaen had the most ortho-diphenols and flavonoids in pruning firewood, and the highest levels of these compounds were located in stem extracts. Jaen also had the highest antioxidant capacity in both pruning firewood and stems across all methods used. Notably, red wine lees displayed the highest biological and antioxidant activities. Moreover, pruning firewood extract displayed great efficacy in inhibiting the growth of Gram-positive bacteria, making it a promising candidate as a natural alternative against antibiotic resistance, which is a global public health concern.