Introduction: Gastroparesis is a disorder characterized by impaired gastric emptying and the accumulation of food in the intestines without any clear mechanical cause. Gastroparesis in critical care patients is a prevalent issue in the intensive care unit. The disruption of normal gastrointestinal motility in critically ill patients is linked to a significant risk of intolerance to enteral feeding, colonization of the gastrointestinal tract with pathogenic bacterial strains, increased permeability of the intestinal wall, translocation of the intestinal microbiota, leading to progressive malnutrition, and potential development of bacterial infection.Materials and methods: The literature was reviewed to assess the benefits and risks associated with the use of this medication.Aim: The aim of the study was to treat the symptoms of gastroparesis and stimulate gastrointestinal motility. Consequently, the aim was to reduce the amount of backed-up food content in the stomach, accelerate gastrointestinal motility, and return to intestinal feeding.Results: Gastroparesis is a frequent issue among patients in the intensive care unit. Critical illness can lead to gastrointestinal motility disorders, causing slowed gastric emptying. This increases the risk of problems such as intolerance to enteral feeding, regurgitation, and aspiration of gastrointestinal contents into the respiratory tract, as well as colonization of the gastrointestinal tract by pathogens. Over time, impaired intestinal absorption can result in malnutrition, necessitating the initiation of parenteral nutrition.Conclusion: After analysis of the literature and published scientific reports, as well as considering their own research, it is evident that erythromycin, as a prokinetic drug, effectively enhances gastrointestinal motility. This contributes to stimulating gastric emptying in critically ill patients with gastroparesis who are hospitalized in an intensive care unit. The use of erythromycin in combination with metoclopramide and/or itopride hydrochloride allows for a synergistic effect, leading to the quickest possible return to enteral feeding.
Sarcopenia and the patient’s nutritional status play an important role in the course of many cardiovascular diseases, including aortic dissection. Disorders of muscle mass and function can affect the body’s ability to recover and the tolerance of surgical and pharmacological treatment. Background/Objectives: In patients with aortic dissection, the presence of sarcopenia may significantly worsen the prognosis and reduce the chances of survival. Weakening of muscle strength and metabolic disorders associated with poor nutrition negatively affect the body’s ability to regenerate after surgical interventions and conservative treatment. The aim of this review was to search the available literature on sarcopenia and nutritional status and their impact on mortality in patients with aortic dissection. Methods: This paper presents a scoping review and reviews the literature from the last 10 years. In the end, six articles which fit the criteria were included in this review. Conclusions: Studies indicate that the presence of sarcopenia correlates with a higher risk of complications and death, so the assessment of nutritional status and muscle function should be an integral part of the diagnosis and treatment of patients with aortic pathology. Nutritional assessment and early nutritional intervention are key to improving the prognosis and quality of life of these patients.
7 October 2024 in Eksploatacja i Niezawodność – Maintenance and Reliability
The Aim of the study was to determine the effect of a carbon fiber enclosure on overvoltages induced in unmanned aerial vehicle (UAV) circuits. Carbon fiber reinforced polymer (CFRP) is characterized by a heterogeneous structure and a thorough analysis of its impact on the LEMP (Lightning ElectroMagnetic Pulse) protection of UAVs is crucial for the further development of such machines. The shorter the distance, the greater the amplitude of the EMP, the greater the value of the surges. Their maximum value determines the safe zone. This distance can be reduced by using an enclosure that can absorb or dissipate EMP. The tested object was placed between a large capacitor plates, which ensured the uniformity of the field. This article presents new results of tests on the CFRP shielding effectiveness against the electrical component of atmospheric discharge. Using described below method, an increase in the signal amplitude inside the box was achieved in relation to the input signal, thus strengthening it instead of suppressing it.
Oxidative stress and sarcopenia are increasingly perceived as interdependent processes that significantly affect the course of cardiovascular diseases. Excessive production of reactive oxygen species leads to muscle cell damage, mitochondrial disorders, and chronic inflammation, which promote progressive loss of muscle mass and function. Methods: The aim of the study was to analyze the mechanisms linking oxidative stress and sarcopenia in the course of cardiovascular diseases. Our scoping review initially identified 854 articles, of which 3 were ultimately included in the review (after removing duplicates (n = 118), 736 articles remained; after re-screening the articles according to the inclusion and exclusion criteria (n = 302), 434 articles remained; 196 publications lacked full text and were excluded, leaving 238 articles). Results: An examination of the available literature indicates a potential association between increased oxidative stress and the possible development of sarcopenia in individuals with cardiovascular diseases. The studies identified in this review suggest that elevated levels of reactive oxygen species, together with reduced antioxidant capacity, may contribute to muscle fiber damage, mitochondrial disturbances, and the activation of chronic inflammatory processes, which could in turn be involved in the accelerated decline of muscle mass and strength. Conclusions: These results confirm that oxidative stress is a key pathophysiological element linking both disease entities and may be an important target of therapeutic interventions.
Introduction: Elderly patients in emergency departments (EDs) are at increased risk due to nonspecific symptoms, multimorbidity, and elevated mortality. This study compared the predictive performance of the Manchester Triage System (MTS) and the Emergency Severity Index (ESI) for hospitalization and critical outcomes in geriatric patients and analyzed symptom patterns by age and clinical course. Methods: This retrospective study included all patients aged ≥18 years admitted to a tertiary ED in northern Poland between January and June 2021. Each patient was concurrently assessed using both MTS and ESI. Data collected included triage level, age group (18–64, 65–79, ≥ 80), sex, mode of arrival, presenting symptoms, and outcomes including hospitalization and ten predefined critical events (e.g., sepsis, admission, urgent surgery). Logistic regression was used to assess associations. Results: Among 1,063 patients, 475 (44.7%) were aged ≥65. Patients aged 18–64 most commonly presented with abdominal pain or polytrauma, while geriatric patients more frequently reported dyspnea, weakness, and altered mental status. Dyspnea was nearly twice as common in patients ≥80. Weakness (OR = 1.67) and abdominal pain (OR = 1.64) were significantly associated with hospitalization. Hospitalization and critical events were more likely in older adults (OR = 2.03 for ages 65–79; OR = 3.74 for ≥80). In both systems, higher triage urgency was independently associated with greater risk (MTS: OR = 0.51; ESI: OR = 0.43). ESI showed stronger alignment with physiological deterioration and predicted complications such as ICU admission and sepsis more consistently than MTS. Conclusions: MTS and ESI show limited sensitivity in older patients, particularly with nonspecific presentations. ESI provided better discrimination of clinical urgency. Findings support revising triage systems to account for age, atypical symptoms, and geriatric vulnerability.
Background/Objective: Postoperative pain and delirium are frequent and clinically relevant complications in patients undergoing major cardiac or neurosurgical procedures. The interaction between these conditions remains insufficiently characterized, particularly across heterogeneous surgical populations. This study aimed to investigate the relationship between postoperative pain intensity and delirium severity within the first 48 h after surgery in cardiac and neurosurgical patients. Methods: This retrospective observational analysis included 408 individuals—202 following cardiac surgery and 206 after neurosurgical procedures. Pain intensity was measured using the Numerical Rating Scale (NRS), while delirium presence and severity were assessed using the CAM-ICU and CAM-ICU-7 instruments. Associations between NRS scores, delirium severity, demographic characteristics, and ICU length of stay were examined. Results: Cardiac surgery patients experienced higher pain levels on postoperative day 1 compared with neurosurgical patients; this difference was not observed on day 2. In the cardiac cohort, higher NRS scores were positively associated with greater delirium severity on both postoperative days. No such association was detected in the neurosurgical group. Pain scores also differed across procedure types within each specialty, and several demographic variables (age, sex, ICU stay duration) were linked with variations in pain intensity. On postoperative day 1, pain intensity showed a moderate association with delirium severity (Spearman ρ = 0.23; 95% CI 0.14–0.32). Patients who developed delirium had higher pain scores (r = 0.25). In ordinal logistic regression, greater pain on postoperative day 1 independently predicted higher delirium severity (OR 2.24; 95% CI 1.70–2.94). Conclusions: Significant associations between postoperative pain intensity and delirium severity were identified in cardiac surgery patients, whereas no similar pattern emerged among neurosurgical patients. Given the retrospective design and incomplete data on perioperative pharmacotherapy, the findings should be interpreted descriptively and do not support causal conclusions. These results underscore the importance of systematic monitoring of pain and cognitive function in high-risk postoperative populations and highlight the need for prospective studies to elucidate the complex interplay between pain, perioperative factors, and postoperative delirium.